United States

Background: Tumor lysis syndrome (TLS) is an oncologic emergency that can occur spontaneously or after chemotherapy administration. Rasburicase, allopurinol, and intravenous fluids are the cornerstone treatments for hyperuricemia. Unfortunately, there is a lack of consistent and evidence-based pattern usage of rasburicase in clinical practice. Inappropriate use can range from 30 to 70%, which leads to institutional financial toxicity, in addition to the unnecessary side effects from rasburicase. Therefore, every attempt should be made to ensure that clinicians follow established TLS guidelines when prescribing rasburicase. 
Methods: Change in the Electronic Medical Record (EMR) system was implemented to add an order set for rasburicase in September 2021. Instead of the previous version of a single-click, ready-to-sign order, the newly incorporated order set had multiple selections that followed a guideline-based algorithm with the aim to ensure the appropriateness of rasburicase use. To investigate if the intervention was successful, all rasburicase orders were reviewed and compared for appropriateness by segregating them into 2 groups (A) before intervention (March-September 2021), and (b) after intervention (October 2021-April 2022). Statistical analysis was done using chi-square, and T-test for categorical and continuous variables respectively.
Results: The study included 67 patients from March 2021-April 2022 [n=31 in pre-intervention, and n=36 in the post-intervention group] (Table 1). Most of the patients had hematological malignancies both in the pre-intervention (n=22/31) and post-intervention group (n=28/36). We found that with the intervention, there was a significant improvement in the percentage of clinicians following the appropriate guidelines while prescribing rasburicase (67.74% versus 88.96%; p = 0.03). With the implementation of this new order set, we were able to reduce inappropriate orders by 21.22%. A review of inappropriate orders showed that isolated hyperuricemia of &lt;12 mg/dL (without TLS) was the most common reason for prescribing rasburicase (n=4/10; 40% in pre-intervention and 3/4; 75% in the post-intervention group). We also noted that 25.81%, and 16.67% of the patients in the pre-, and post-intervention groups were not prescribed allopurinol, respectively (p&lt;0.001). 
Conclusion: A newly implemented and multistep, algorithm-based order set helped us to reduce inappropriate rasburicase use, which significantly reduced unwanted side effects, and also financial toxicity.

AMA Research Challenge 2023

Implementation Of A New Electronic Medical Record Algorithm To Streamline The Appropriate Use Of Rasburicase

Background: Tumor lysis syndrome (TLS) is an oncologic emergency that can occur spontaneously or after chemotherapy administration. Rasburicase, allopurinol, and intravenous fluids are the cornerstone treatments for hyperuricemia. Unfortunately, there is a lack of consistent and evidence-based pattern usage of rasburicase in clinical practice. Inappropriate use can range from 30 to 70%, which leads to institutional financial toxicity, in addition to the unnecessary side effects from rasburicase. Therefore, every attempt should be made to ensure that clinicians follow established TLS guidelines when prescribing rasburicase. 
Methods: Change in the Electronic Medical Record (EMR) system was implemented to add an order set for rasburicase in September 2021. Instead of the previous version of a single-click, ready-to-sign order, the newly incorporated order set had multiple selections that followed a guideline-based algorithm with the aim to ensure the appropriateness of rasburicase use. To investigate if the intervention was successful, all rasburicase orders were reviewed and compared for appropriateness by segregating them into 2 groups (A) before intervention (March-September 2021), and (b) after intervention (October 2021-April 2022). Statistical analysis was done using chi-square, and T-test for categorical and continuous variables respectively.
Results: The study included 67 patients from March 2021-April 2022 [n=31 in pre-intervention, and n=36 in the post-intervention group] (Table 1). Most of the patients had hematological malignancies both in the pre-intervention (n=22/31) and post-intervention group (n=28/36). We found that with the intervention, there was a significant improvement in the percentage of clinicians following the appropriate guidelines while prescribing rasburicase (67.74% versus 88.96%; p = 0.03). With the implementation of this new order set, we were able to reduce inappropriate orders by 21.22%. A review of inappropriate orders showed that isolated hyperuricemia of <12 mg/dL (without TLS) was the most common reason for prescribing rasburicase (n=4/10; 40% in pre-intervention and 3/4; 75% in the post-intervention group). We also noted that 25.81%, and 16.67% of the patients in the pre-, and post-intervention groups were not prescribed allopurinol, respectively (p<0.001). 
Conclusion: A newly implemented and multistep, algorithm-based order set helped us to reduce inappropriate rasburicase use, which significantly reduced unwanted side effects, and also financial toxicity.

poster

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Background:
Arab Americans are one of the largest ethnic groups in the United States. However, the mental health of Arab Americans and their opinions on mental health remain largely understudied despite high rates of mental illness and lower rates of treatment. Unique cultural conceptualizations of mental illness might generate stigma, which contributes to disparities in treatment. We assessed the attitudes and perspectives of Arab Americans about mental illness to address barriers to treatment.

Methods:
Responses were collected through an anonymous bilingual Qualtrics survey from both Arab and non-Arab participants aged 18-years and older. Participants were assessed on stigma towards mental illness and mental health treatment. conceptualizations of mental illness origins, preferred resources for treatment, and perceived barriers to accessing treatment. Comparisons were performed between Arabs and non-Arabs and among Arabs using different demographic parameters. Data analysis was conducted on SPSS using chi-squared analyses, ANCOVA, and T-tests. 

Results:
Compared to non-Arabs, Arabs have significantly higher average stigma towards mental illness (t(292) = -3.42, p < .001) and were more likely to rate psychiatric medications as addictive and unhelpful (t(292) = -2.93, p = .004; t(292) = -3.09, p = .013). Additionally, among Arabs, being Christian, male, and older increased stigma (t(194) = 2.10, p=.037; t(216) = 4.889, p < .001; t(216) = 2.16, p = .037). Regarding beliefs about mental illness, Arabs were less likely to believe in a biological explanation for mental illness compared to non-Arabs (χ² = 10.629, p = .001). Arabs were also less likely than non-Arabs to choose treatment from a therapist or primary care provider (χ² = 5.24, p = .022; χ² = 5.001; p = .025) and more likely to defer mental health treatment entirely (χ² = 6.410; p = .011). Among Arabs, females were more likely to prefer a therapist than males (χ² = 10.562, p = .001). Finally, Arabs were more likely than non-Arabs to endorse fear of being called “crazy” and provider cultural differences as barriers to seeking mental health treatment (χ² = 6.430, p = .011; χ² = 20.274, p < .001). 

Conclusion: 
Our results demonstrate an increased stigma against mental illness among Arab Americans and hesitancy to seek treatment due to social repercussions from the community and cultural discrepancies. 

Significance:
These are among the first findings describing mental illness stigma and barriers to mental health treatment access in the Arab American population and may inform future community interventions providing culturally competent care to Arab Americans.

Exploring Arab American Mental Health Conceptualization and Stigma in Southeast Michigan

Calendar and Volume Trends in CTA Interpretation: Exam Volume Doesn’t Explain It All

Background 
Peer feedback in medical education is a well-studied means of helping students promote self-reflection, identify knowledge gaps, and foster professionalism and communication skills. While multiple medical schools have documented positive outcomes from peer feedback instruction, it is not clear that the quality of peer feedback was specifically assessed during these interventions. Our study evaluates the impact of a “feedback on feedback” exercise on students’ confidence in delivering and receiving peer feedback. We also evaluate student perceptions of instruction on peer feedback and the “feedback on feedback” exercise.

Methods
We created a peer feedback session for first-year medical students at UC Davis for AY2022-23. To prepare for the session, students watched a pre-recorded video on delivering effective feedback that included two demonstration peer feedback scenarios. In class, students provided their peers with feedback following standardized patient encounters. Feedback providers subsequently received feedback on the quality of their feedback from a faculty or fourth-year medical student facilitator. We assessed students’ perceptions of this session and confidence surrounding peer feedback with pre- and post-session surveys and analyzed the data using a two-tailed t-test. 

Results
Ninety-three percent (104/112) and 92% (98/107) of participating medical students responded to the pre- and post-session surveys, respectively. There was a significant difference in students’ self-reported confidence in their ability to provide their peers with effective feedback in a clinical setting before (M = 3.91, SD = 0.68) and after (M = 4.13, 0.60) the session; t(199) = -2.42, p = 0.02. There was also a significant difference in students’ self-reported confidence in their peers’ ability to provide them with effective feedback in a clinical setting before (M = 3.97, SD = 0.66) and after (M = 4.16, 0.58) the session; t(200) = -2.19, p = 0.03. Additionally, most students (33/41, 80%) agreed or strongly agreed that the “feedback on feedback” they received improved their ability to give effective feedback in the future. Students frequently cited learning about different feedback frameworks as the most useful part of the module (19/64, 30%), followed by positive effects on their professional development (15/64, 23%).

Conclusion
Providing medical students with formal training in delivering effective peer feedback, including providing them with feedback on the quality of their feedback, can increase their confidence in their ability to deliver and receive feedback – a skill that is critical for their role as future physicians and educators. 


"Let's Unpack My Feedback!" - An Approach to Enhance Medical Students' Peer Feedback

Background: 
Following devastating hurricanes, such as Hurricane Ike and Hurricane Harvey, Galveston has struggled to replenish its previously existing affordable housing infrastructure due to socioeconomic and political forces. This has caused many to fall into homelessness or live in unstable housing situations. According to the 2022 Point in Time Count, there are 166 reported individuals experiencing homelessness in Galveston County. Street Medicine Galveston aims to meet unhoused individuals where they are in the community through Street Rounds, care for their physical and social needs, and bridge gaps in collaboration between Galveston organizations serving this population. 

Methods: 
We provide essential living necessities, seasonal supplies (winter gear, bug spray, sunscreen, etc.), wound care, and healthy meals from produce donated by community gardens and Galveston’s Own Farmers Market. Additionally, we have created a community network with several other community organizations that serve the unhoused community which allows us to refer individuals to the appropriate resources based on their unique needs.

Results: 
Through Street Rounds, we have learned that meeting unhoused individuals where they are within the community provides a unique solution to several barriers to care including lack of transportation and limited cellular/ internet access. Additionally, levels of education and awareness of available social resources vary widely within this population. By consolidating a community resource guide, our team bridges these gaps by providing recommendations for what community resources to visit based on their expressed needs. Lastly, within the past year, we have been able to serve 253 individuals thus far, 94 of which are recurrent clients and 174 who are new clients. This is a greater number of individuals than were reported within the Galveston County Point in Time Count. 

Conclusions: 
Through Street Rounds, we were able to collaborate and form trusting relationships with the unhoused community as well as several community partners. In the span of 10 months, we were able to serve a total of 253 people experiencing homelessness. With the help of donations, we were able to successfully provide winter gear for more than 50 people and assisted with referrals to other services in Galveston. In the future, we hope to continue exploring different avenues like collaborating with social services, and medical specialties like Psychiatry to provide further care.

Street Medicine Galveston: How We Created a Community Resource Network

Background: Despite advances in mental healthcare in the U.S., only 46.2% of adults diagnosed with any mental illness and 64.5% of those with severe mental illness received mental health treatment in 2020. Primary care providers (PCPs) are at the front lines of identifying and treating mental health conditions and are essential in bridging the mental health treatment gap. The present study examines the relationship between having a PCP and perceived unmet mental health treatment need in adults living in New York City (NYC).  
Methods: This cross-sectional study uses data from the 2019 and 2020 NYC community health survey (CHS). The two years were compared to account for any effect of the COVID-19 pandemic on access to PCPs. Unadjusted odds ratios were used to identify predictors of having a PCP. A binary logistic regression model assessed the association between having a PCP and perceived unmet mental health treatment need, adjusting for sociodemographic and clinical covariates. Post-stratification survey weights were applied using SPSS complex samples.   
Results: In 2019 and 2020, 25.1% and 29.7% of those with non-specific psychological distress (NSPD), respectively, had perceived unmet mental health treatment need. Having no insurance (2019: OR 0.082, 95% CI 0.063, 0.105, p=0.000; 2020: OR 0.171, 95% CI 0.137, 0.214 p=0.000), having perceived unmet medical (2019: OR 0.471 95% CI 0.358, 0.620 p<0.001; 2020: OR 0.656, 95% CI 0.522, 0.825 p<0.001), and mental health treatment need (2019: OR 0.580 95% CI 0.376, 0.894 p=0.014; 2020: OR 0.613 95% CI 0.435, 0.865, p=0.005) were associated with reduced odds of having a PCP. Adults lacking a PCP had increased odds of perceived unmet mental health treatment need in unadjusted analysis, but after adjusting for confounders, this relationship no longer reached statistical significance. Having NSPD (2019: OR 8.632 95% CI 5.506, 13.532, p=0.000; 2020: OR 11.108, 95% CI 7.404, 16.664) and perceived unmet medical treatment need (2019: OR 5.332 95% CI 3.466, 8.203, p <0.001; 2020: OR 3.5857 95% CI 2.583, 5.758, p<0.001) was associated with increased odds of perceived unmet mental health treatment need.   
Conclusion: More than a quarter of NYC adults needing mental health treatment perceived unmet mental health treatment need. To improve access to quality healthcare both within and outside the primary care setting, there needs to be improved patient health literacy, enhanced healthcare professional training in cultural competence and mental health management, and regular mental health screenings and integration of behavioral health into primary care.

The effect of access to a primary care provider on perceived unmet mental health treatment need in NYC adults

COVID-19 Vaccine Uptake and Perceptions among Hispanics/Latinos: Disparities, Hesitancy, and Implications for Equitable Access

Background
Prior research has shown disparities in lung transplantation rates between racial groups, with Asian patients having lower rates of transplantation from the waitlist compared to Hispanic, Black, and White patients. While studies have delved into the characteristics of patients from other racial groups, little is known about the characteristics of Asian patients on the waitlist. This study aims to reveal key characteristics of Asian patients on the lung transplant waitlist using the UNOS/OPTN database to guide future interventions.

Methods
The UNOS/OPTN database was used to evaluate and compare the demographic and clinical characteristics of patients on the lung transplant waitlist. Transplant data were used from October 1987 until June 2023. Pediatric patients (age <18 years) and patients of ethnicities other than White or Asian were excluded from the study. Descriptive analysis was performed, and data was evaluated for statistical significance using Chi-Square for categorical variables and the Kruskal-Wallis test for non-normal continuous variables. The analysis was conducted using R (Version 4.3.1).


Results
A total of 56,530 White patients and 1375 Asian patients from the UNOS database met the study criteria. Asian patients were less likely than White patients to receive a transplant (64.4% vs 70.5%; p<.001) while also having a higher median Lung Allocation Score of 42.35 [IQR 36.96-54.44] compared to 37.21 [IQR 33.60-44.61] for White patients (p<.001). Waitlist mortality was higher in Asian patients at 10.5% compared to 8.4% for White patients (p=.006). Asian patients were more likely to have a college degree (53.5% vs 27.4%; p<.001) and had lower rates of obesity at time of listing (6.8% vs 14.8%; p<.001) but higher rates of diabetes (26.3% vs 15.8%; p<.001). Primary diagnosis differed between Asian and White patients, with the top three primary diagnoses being Idiopathic Pulmonary Fibrosis (39.5% vs 27.7%), COPD/Emphysema (5.2% vs 26.9%), Cystic Fibrosis (1.2% vs 11.8%) respectively (p<.001). There was no statistical difference in the percentage of Asian patients compared to White patients with private insurance (58.8% vs 56.7%, p=.142).

Conclusion
This study suggests that disparities exist for Asian patients on the waitlist for lung transplant. Despite higher median Lung Allocation Scores, Asians patients are less likely to be transplanted and have increased waitlist mortality compared to White patients. More research is needed on the effect of primary diagnosis and other factors that could cause this disparity.

Disparities and Characteristics of Asian Patients on the Lung Transplant Waitlist

Background 

Heart disease is the leading cause of death of in the US. A key part of decreasing mortality is decreasing major cardiovascular (CVD) risk factors— hypertension (HTN), diabetes (DM), and hypercholesterolemia (HLD)— which often requires regular visits to a healthcare provider. Despite wider access to health insurance with the Affordable Care Act (ACA), healthcare costs continue to significantly impact patient decision-making and engagement. Health insurance has evolved: high-deductible health plans, which can have high out-of-pocket costs, have become more popular. In 2021, costs led half of US adults to skip health/dental care, and almost a third to skip medication doses. The effect of this phenomenon—underinsurance—should be explored.​ 



While there was focus on uninsurance prior to ACA, there is far less literature on underinsurance. An examination of insurance’s impact on disease progression is also absent from the literature. This study explores associations between self-reported health insurance status, chronic health conditions, acute coronary syndrome (ACS) events, and CVD risk factor progression. 



Methods 

This study utilizes 2021 national data from the Center for Disease Control’s Behavioral Risk Factor Surveillance System, a cross-sectional study performed as a telephone survey with 358,899 completed records over the 50 states, DC and Guam. After applying complex sampling weights, Rao-Scott chi-squared tests, 95% confidence intervals, and relative risk ratios were calculated with SAS. 

Results 

Inability to see a doctor due to cost in the past year was associated with insurance type (p < 0.0001), with the Indian Health Service, state sponsored health plans, and Medicaid performing the worst. Perceived underinsurance significantly correlated with increased MI, stroke, and diabetes(p<0.001) but decreased awareness of having HTN, HLD, and angina/CAD(p<0.001). This also correlated with increased CVD events amongst those with known risk factors by 3-5%. 

Conclusion 

The impact that insurance has upon willingness to access care highlights the underperformance of the Indian Health Service, state sponsored health plans, and Medicaid amongst others.​ While patient-perceived underinsurance was associated with worsened outcomes and progression of risk factors, the reduced awareness of HLD or HTN highlights that financially-driven lack of care may stop patients from being aware of risk factors before a serious health event occurs. These findings emphasize the need to advocate for improved insurance coverage as a standard and further research to investigate possible cost-effective improvements for the healthcare system: changes in how physicians and social workers counsel patients, how insurers set benefit designs, and how policy is influenced.

Past the Fine Print: The Impact of Insurance Status on the Relationship Between ACS Risk Factors and Events

Background: Triple negative breast cancer (TNBC) is a highly invasive breast cancer subtype that disproportionately occurs in young Black women and those with Breast Cancer 1 (BRCA1) germline mutations. Although TNBC incidence is highest in Black women, germline BRCA1 mutation prevalence is lower in Black women than in White women. Black communities are exposed to environmental pollutants, including heavy metals, because of historical housing discrimination. Current TNBC disparities may be, in part, explained by increased heavy metal exposure. Cadmium (Cd) is a metalloestrogenic heavy metal and clastogen that causes cancer. DNA double strand breaks (DSBs) contribute to genomic instability that drives cancer development. DSBs are repaired primarily by either homologous recombination (HR) or classical non-homologous end joining (cNHEJ) repair. Loss of HR or cNHEJ leads to increased use of error-prone alternative NHEJ (aNHEJ) which promotes genetic instability that can inactivate tumor suppressor genes or activate oncogenes to drive carcinogenesis. The DNA Damage Response (DDR) is a signaling cascade that coordinates both cell cycle arrest and DSB repair. Several DDR proteins require Zn to function and Cd can displace Zn from Zn coordinating proteins. Based on this evidence, we hypothesized that chronic Cd exposure promotes TNBC initiation by disrupting the DNA Damage Response.
Methods: Immortalized breast epithelial cells (MCF 10A) were exposed to 0 or 2.5 µM Cd for 8 weeks. Neutral COMET assays were performed to detect DSBs and quantified using OpenComet ImageJ software. Immunoblotting was performed for proteins important for HR and cNHEJ signaling, including activated (phosphorylated) and total H2AX, ATM, DNA-PKcs, CHEK2, P53, BRCA1, BRCA2, RB1, and total CDKN1A and MDM2. Data were analyzed using unpaired student’s two-tailed t-test with Welch’s correction (immunoblotting) or Mann Whitney test (COMET assay).
Results: Chronic Cd exposure induced DSB accumulation, reduced BRCA1 phosphorylation and CDKN1A expression, and induced TP53 phosphorylation, TP53 protein levels and RB1 phosphorylation.
Conclusion: The DDR normally signals cell cycle arrest in response to DSBs. Decreased activation of BRCA1 likely contributes to decreased repair and increased accumulation of DSBs. Chronic Cd exposure significantly disrupted the DDR at the cell cycle control level by decreasing CDKN1A expression. CDKN1A normally inhibits CDK-dependent phosphorylation of RB1 and RB1 phosphorylation promotes cell cycle progression despite the increase in DSBs. 





Chronic Cadmium Exposure Suppresses the DNA Damage Response

HuBMAP is a research consortium aiming to develop a framework for mapping the human body at single cell resolution. Through molecular analysis technologies and computational tools, an atlas composed of 3D tissue maps will be created to accelerate our understanding of the function and relationships among cells in accordance with our health. Though operative, it remains challenging for metadata to maintain FAIR standards without enforced, controlled vocabularies and internal linkages to ontologies and metadata standards. To be considered FAIR, metadata must be findable, accessible, interoperable, and reusable. In efforts to create such metadata, we have collaborated with the Center for Enhanced Data Annotation and Retrieval (CEDAR) to develop metadata templates linked to ontologies and standards present in the NCBO Bioportal. This study investigated whether existing HuBMAP metadata can be integrated into CEDAR templates to simplify the workflow of data submission, processing, validation, and publication to optimize the metadata pathway. Using the HuBMAP Sample Data v2b Spreadsheet (an Excel spreadsheet containing data on how the tissue sample was collected, processed, and stored), 3 templates were created in CEDAR: Sample Block, Sample Section, and Sample Suspension. There were various concepts in the sample data spreadsheet that could not found the BioPortal repository. For those concepts, vocabularies were created using Excel, converted into RDF files through SKOS Play, and submitted as new ontologies into BioPortal. With the newly available ontologies, templates were created and published in CEDAR. Our results show that this metadata management framework supports authoring, curation, validation, management, and sharing of HuBMAP metadata. CEDAR technology allows users to guarantee their input metadata are FAIR prior to submission for public release. We hope to expose limitations in our model and issues in the metadata being collected by HuBMAP to identify problems in how the experiment is being described. Upon integrating the submission of all these components into one submission tool and workflow, we aim to significantly simplify the workflow of HuBMAP dataset submission, processing, validation, registration, and publication to optimize the metadata pathway from submission to discovery and allow more datasets to become cross-searchable.

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Exploring Arab American Mental Health Conceptualization and Stigma in Southeast Michigan