United Kingdom

**Abstract authors:**

Alex Devarajan¹, Mais Al-Kawaz¹, Jessica Bonet¹, Daryl Goldman¹, Christina Rossitto¹, Michelle Sorscher¹, Peter Morgenstern¹, Tomoyoshi Shigematsu¹, Alejandro Berenstein¹, Johanna Fifi¹

¹Icahn School of Medicine at Mount Sinai

**Abstract body:**

Introduction Patients with Vein of Galen malformations (VOGM) can develop significant angiogenesis leading to hemodynamic and structural remodeling. This results in an extensive fine angiogenic network fistulizing to the vein of Galen. In patients with angiogenic networks, transarterial embolization (TAE) is challenging due to poor penetration and access while transvenous approaches (TVE) carry a risk of hemorrhage from pathologic vasculature. These patients present early and symptomatically and can have devastating outcomes if not treated. Objective We illustrate the case of a pediatric patient who presented with an angiogenic VOGM ultimately treated by staged TAE with a miniature dual-lumen balloon microcatheter (DLBC) and curative TVE. Case Presentation A 12-month-old boy presented after VOGM was identified during workup for progressive hydrocephalus. Endovascular embolization was offered. The infant underwent five staged TAE, followed by curative TVE via pressure cooker technique. Initial pre-embolization angiogram demonstrated a diffuse vascular network within the third ventricle and choroidal fissure superiorly feeding the malformation. Because the network complicated fistulous point access, a miniature DLBC was utilized to achieve distal pedicle flow arrest and partial network devascularization. Postoperatively, the embolization was complicated by IVH and hydrocephalus requiring an ETV with no lasting neurological deficit. For the final embolization, given the arterial morphology and progressive venous reduction, TVE was the technically easiest choice to achieve angiographic cure. Follow-up angiogram demonstrated complete obliteration of the malformation and subsequent clinical follow-up demonstrated improvements in milestones. Conclusion Through a combination of new technologies and techniques, technically challenging VOGMs are now curable. The patient is able to achieve a relatively normal quality of life due to timely and effective treatment.

IPSO 2023

Angiographic Cure of a Highly Angiogenic Vein of Galen Malformation by Staged Transarterial and Transvenous Embolization: Case Report

Dear IPSO Virtual Conference Attendees:

Welcome to the IPSO 2023 Virtual Conference. We are delighted to bring together experts from multiple disciplines and six continents to provide a diverse perspective on pediatric cerebrovascular disease.

A few quick words about what to expect. Two important goals of this conference are to (1) foster a sense of community and (2) identify global priorities for our field. We encourage you to express your thoughts live in through the chat function to provide a global perspective on all topics. Please introduce yourself in the chat, so everyone knows where you are attending from.

We are excited to announce IPSO is able to offer 9.5 CME units for the virtual conference. If you would like to claim CME credits, please email membership@internationalpediatricstroke.org. 

We want to hear from you! Planning for IPSO 2024 Congress on March 22nd-24th in Toronto, Canada, will commence as soon as the Virtual Conference ends. Let us know your priorities through the live chat function, via email, or by submitting a symposium idea. Based on your input, the Scientific Program Committee will select the topics that we will address in greater depth when we meet again in the spring.

We hope you find the Virtual Conference both interesting and educational, and hope to see you in person in Toronto, or at another IPSO meeting in the future.

Warm regards,

Heather Fullerton, IPSO President 
Maja Steinlin, IPSO Vice-President 
Lori Jordan, IPSO Secretary & Treasurer 
Noma Dlamini, IPSO Scientific Program Committee Chair 


The International Pediatric Stroke Organization (IPSO) 2023 Virtual Conference is April 28-29th, 2023. The mission of the virtual conference is to unify the global community of professionals engaged in research and clinical care for children with cerebrovascular diseases, and chart a path forward for multinational, multidisciplinary efforts. Similar to the IPSO 2021 Virtual Conference, IPSO has partnered with Underline to host this virtual conference. 

The 2023 IPSO Virtual Conference will offer:

* A highly interactive format: brief recorded talks followed by live panel discussions with audience participation through a chat function and live audience surveys
* Optional break-out groups for IPSO committees, working groups, councils
* Poster sessions available on-demand throughout the conference with a chat function for the audience to comment for ask questions of the presenters

Disclaimer: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of UCSF and the International Pediatric Stroke Organization (IPSO) and Hospital for Sick Children, and Vanderbilt University Medical Center. UCSF is accredited by the ACCME to provide continuing medical education for physicians.

 UCSF designates this live activity for a maximum of 9.5 AMA PRA Category 1 credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Contact membership@internationalpediatricstroke.org if you would like to claim CME for the IPSO 2023 Virtual Conference. 

**About** 
Founded in February, 2019, we are an organization of health professionals, scientists and patient advocates who care about stroke and other cerebrovascular diseases in childhood. We developed out of our original collaborative network, the International Pediatric Stroke Study (IPSS), and now aim to broaden the scope of our mission beyond research.

* Our mission is to improve the lives of children worldwide with cerebrovascular disease through research, education, clinical care and advocacy.

* Our Vision is a world in which international, multidisciplinary collaborations advance the understanding, care, and outcomes of childhood cerebrovascular disease.

To access IPSO 2023 site, please register [here](https://internationalpediatricstroke.org/2023-virtual-conference/registration/). 

The mission of the International Pediatric Stroke Organization (IPSO) 2023 Virtual Conference is to unify the global community of professionals engaged in research and clinical care for children with cerebrovascular diseases, and chart a path forward for multinational, multidisciplinary efforts. 



poster

**Abstract authors:**

Alex Devarajan¹, Jessica Bonet¹, Alexander Schupper¹, Christina Rossitto¹, Michelle Sorscher¹, Alejandro Berenstein¹, Johanna Fifi¹, Tomoyoshi Shigematsu¹

¹Icahn School of Medicine at Mount Sinai

**Abstract body:**

Introduction Vein of Galen Malformations (VOGM) are congenital arteriovenous malformations (AVM) primarily treated by endovascular embolization via transarterial (TAE) or transvenous (TVE) approaches. TVE can be utilized to close the malformation but carries risk of venous congestion and redirection of venous outflow with significant neurologic consequences. Objective Here, we illustrate the atypical use of an intracranial venous sinus stent to improve normal venous outflow after TVE in the case of a pediatric patient with VOGM. Case A 3-year-old girl presented for continued management of VOGM. She had received six prior TAEs at the senior author's institution: after progressive reduction of the malformation, she was a suitable candidate for TVE. Pre-embolization angiogram demonstrated a choroidal type VOGM with venous hypertension: the vein of Galen drained retrograde through the vein of Labbe, the left transverse sinus drained into cortical cerebellar veins without opacification of the left sigmoid sinus, and stenosis of the right sigmoid-jugular junction was present. Balloon angioplasty of the right sigmoid-jugular junction was performed to aid guide catheter navigation. After TVE by pressure cooker technique, balloon-assisted venous sinus stenting was performed at the right sigmoid-jugular junction to aid normal venous sinus drainage. Post-embolization angiogram demonstrated reduced shunting through the malformation and reduced aberrant cortical venous drainage. Shunted blood mainly drained to the right transverse-sigmoid sinuses with marked improvement of venous diameter and flow. The patient experienced no postoperative complications and clinical follow-up demonstrated improvement in milestones. A second TVE resulted in complete occlusion. Conclusion In patients with VOGM and venous hypertension receiving TVE, venous sinus stenting may be a safe and effective option to reduce aberrant cortical venous drainage and improve normal outflow.

Adjunctive Venous Sinus Stenting in Transvenous Embolization of Vein of Galen Malformation: Case Report

**Abstract authors:**

Zokirzhon Zokhidov¹, Matvey Livshits¹, Inna Shchederkina¹, Gennady Chmutin¹, Sergey Ozerov¹, Alexander Levov¹, Madina Berdieva¹, Anastasia Vergizovа¹

¹Morozov Children's Clinical Hospital

**Abstract body:**

Relevance: Arteriovenous malformation (AVM) in children is a risk factor for hemorrhagic stroke. Materials: The study included 72 children who applied to "Morozov Children's City Clinical Hospital, with a diagnosis of AVM of the cerebral vessels with the presence of intracerebral hematoma. Age ranged from 1 month. up to 18 years old, the median age at diagnosis was 9.6. Boys vs girls-36(50%) vs 35 (50%) Methods: Of 72 children, surgical treatment was performed in 61. Seven patients were not operated on, after stabilization of their condition, they were referred for stereotaxic radiosurgery. 4 patients died. Cerebral deficit was the leading symptom in 52 patients. In 17 patients, the assessment of focal symptoms was difficult due to the severity of the condition. The level of impaired consciousness: clear consciousness in 17 (23.6%), stunning in 23 (31.9%), stupor in 15 (20.9%), coma in 17 (23.6%). The most common localization of AVMs is the parietal lobe. Distribution of patients according to Spetzler-Martin gradation: AVM: type I -- 9 (12.5% %), type II -- 21 (29.2%), type III -- 26 (36.1%), IV -- 13 (18, 1%), V -- 3 (4.1%) patients. The volume of intracranial hematoma ranged from 9 ml to 130 ml. The results: based on the timing of admission to the hospital, the severity of the patient's condition, the size and location of the hematoma, its relationship to the mid-stem and basal structures, a decision was made on the need and extent of surgical intervention. Type of operation: microsurgical in 31 (51%) patients, embolization in 12 (20%) patients and combined intervention (microsurgery + embolization) - in 18 (29%) patients. Outcome: complete regression of neurological symptoms in 34 (55.7%) patients, moderate disability in 20 (32.8%) patients, severe disability in -7 (11.5%) patients. Conclusion: Surgical tactics as early as possible allows to achieve good outcomes in most patients.

Treatment of children with ruptured arteriovenous malformation at the Primary Pediatric Stroke in Moscow

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Adjunctive Venous Sinus Stenting in Transvenous Embolization of Vein of Galen Malformation: Case Report

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Adjunctive Venous Sinus Stenting in Transvenous Embolization of Vein of Galen Malformation: Case Report