United States

Background
Home rapid antigen tests (RATs) are widely available, partially due to government distribution programs. Time-sensitive clinical decisions about provision of ambulatory COVID-19 care can depend on the results of these studies, which are often more readily accessible than clinician-performed tests. It is assumed that the two are similarly accurate. However, few studies of self-test RAT accuracy exist. Here, we compare the accuracy of patient-performed and clinician-performed BinaxNOW RATs using PCR as a gold standard.

Methods
All adult patients between February 12, 2022 and May 18, 2022 at a free state testing site in Baltimore, USA, were offered enrollment. Demographic and symptom status were recorded. 3 samples were obtained from each participant: clinicians sampled bilateral nares for PCR and RAT, after which participants self-tested using identical RATs. Sensitivity and specificity were compared using Chi-square. 

Results
625 patients participated. 60.6% were female, 58.6% were white, 98.2% were English speaking, and median age was 34 (IQR: 28, 48.5). 34.1% were symptomatic and 14.9% were PCR positive by PCR. Clinician and self-performed RATs had similar sensitivity (88.2% [95% CI: 80.1%, 93.2%] vs 83.9% [95% CI: 75.1%, 90.0%] P= 0.40) and specificity (99.6% [95% CI: 98.5%, 99.9%] vs 99.8% [95% CI: 98.8%, 100%] P= 0.57). In symptomatic patients, self-test had a sensitivity of 94.5% (95% CI: 86.6-98.5) and specificity of 62.5% (95% CI: 24.5-91.5). For asymptomatic patients, self-test had a sensitivity of 66.7% (95% CI: 29.9-92.5) and specificity of 100% (95% CI: 29.2-100.0). These were similar to clinical PCR as well. 

Conclusion
Clinician-performed and self-performed RATs had similarly high accuracy. The high observed sensitivity of home RATs supports their continued usage in ambulatory decision-making to identify eligible candidates for COVID-19 therapeutics. Their accessibility is key, since federal policy now states that patients are treatment eligible for a maximum of 7 days. Self-performed RATs reduce barriers including time needed to search for and then attend clinician appointments, and allow patients to play a larger role in their own care. Low false positive rates mitigate concerns about poor technique or contamination, and ensure that treatment is appropriate. Our study supports continued use of home RATs for clinical decision making.

AMA Research Challenge 2022

Comparison of Accuracy of Self-Test and Clinical Rapid Antigen Testing for Coronavirus-19 (COVID-19)

**About**
 The PErvasive Technologies Related to Assistive Environments (PETRA) conference is a highly interdisciplinary conference that focuses on computational and engineering approaches to improve the quality of life and enhance human performance in a wide range of settings, in the workplace, at home, in public spaces, urban environments, and other. Outcomes of this conference have a broad impact in application areas that include, manufacturing, transportation, healthcare, energy systems, security and safety, robotics, biomedicine, environment and conservation, and many others. PETRA brings together very different types of technologies to also address important social and healthcare issues for sensitive populations, such as the elderly, persons suffering from chronic conditions such as Alzheimer’s, Parkinson’s, Cerebral Palsy, and other disabilities or traumas.

 PETRA (which means “stone” in Greek) addresses important human living needs. From a technological perspective, PETRA motivates and inspires new scientific thrusts, innovations and discoveries to improve living environments, a particularly important issue, in an increasingly crowded and complex world where the need for inclusiveness and connectivity with the rest of the world is key. For the elderly in particular, PETRA addresses the fact that, as people grow older; they will increasingly rely on technology to be able to prolong staying in their homes and enjoy an independent life.

 The PETRA 2021 proceedings will be published in the ACM Digital Library as part of the ACM ICPS program. The ISBN number assigned to PETRA '21 is 978-1-4503-8792-7

PETRA 2021

The PErvasive Technologies Related to Assistive Environments (PETRA) conference is a highly interdisciplinary conference that focuses on computational and engineering approaches to improve the quality of life and enhance human performance in a wide range of settings, in the workplace, at home, in public spaces, urban environments, and other. Outcomes of this conference have a broad impact in application areas that include, manufacturing, transportation, healthcare, energy systems, security and safety, robotics, biomedicine, environment and conservation, and many others. PETRA brings together very different types of technologies to also address important social and healthcare issues for sensitive populations, such as the elderly, persons suffering from chronic conditions such as Alzheimer’s, Parkinson’s, Cerebral Palsy, and other disabilities or traumas.

poster

Welcome to the largest national, multi-specialty research event **featuring research from 750 medical students, residents and fellows, and international medical graduates.**


#### Event Details
The 2022 American Medical Association Research Challenge includes a poster symposium hall and a semifinals hall with the top scored research. Log in at any time throughout the event to:
* **View posters and presentations** on a variety of topics and specialties
* **Score posters in the semifinals** to help decide the top five finalists (AMA member exclusive opportunity)
* **Connect with participants** and provide feedback to help advance their research

At the conclusion of this event, the AMA will announce the top five finalists who will advance to the AMA Research Challenge finals, present their research to an elite panel of judges and compete to win a $10,000 grand prize sponsored by Laurel Road.
 

#### Attend Live Forums
**Oct. 20, 6 — 7 p.m. Central**
 **How to plan a career in academic medicine** 
 Learn how to plan a career in academic medicine and get your questions answered. [Access Here](https://underline.io/events/363/lounge)
 
 **Speakers**
![](https://assets.underline.io/uploads/markdown_image/1/image/d5adb133dfc58eb0a6d469e9cedcd5d4.jpg)
Ricardo Correa, MD, EdD
![](https://assets.underline.io/uploads/markdown_image/1/image/5f9437ab87861538bf02b9ca7c0d926e.jpg)
Stuart M. Greenstein, MD
![](https://assets.underline.io/uploads/markdown_image/1/image/05b1b637c99286d558c371f8e8b185ce.jpg)
Stephanie Strohbeen, MD
 
 **Oct. 22, 11 a.m. — Noon Central**
 **How to get published**
 Learn tips to get your research published and get your questions answered. [Access Here](https://underline.io/events/363/lounge)
 
 **Speakers**
![](https://assets.underline.io/uploads/markdown_image/1/image/8ce6235e957d31cb5e6f9097cc6f6972.jpg)
Jessica Li, MD/PhD Candidate
![](https://assets.underline.io/uploads/markdown_image/1/image/9950ef2e0237f54cb3d8280334d42491.jpg)
Charles Lopresto, DO

### Sponsor
AMA would like to thank Laurel Road for sponsoring a $10,000 grand prize for the winner of the AMA Research Challenge. Laurel Road is not involved in the judging or scoring process to select the winner. The winner will be announced on Dec. 7 during the AMA Research Challenge finals. Payment of the grand prize will be directly from Laurel Road. See the AMA Research Challenge Official Rules for terms and conditions.

![](https://assets.underline.io/uploads/markdown_image/1/image/611e331d4a0eba0920f240cfc04b4d77.png)

**There is no registration fee for this event! **

Register to explore research in a variety of topics. AMA members get exclusive access to score posters in the semifinals.

**Please use the link below to register for free if you have not already done so:**

https://www.ama-assn.org/about/events/ama-research-challenge

Registration Is Required

Welcome to the largest national, multi-specialty research event featuring research from 750 medical students, residents and fellows, and international medical graduates.


Background
Non-urgent use of the emergency department (ED) is costly for patients. It can lead to increased healthcare spending and ED overcrowding and negatively affect primary care physician (PCP)-patient relationships. We aim to evaluate the association between perceived medical urgency, PCP coverage (whether a patient has a PCP), and patient descriptive characteristics with utilization of the ED for non-urgent clinical care.

Methods
Adult ED patients were stratified to preventable and non-preventable ED visits according to their emergency severity index (ESI) at the UC Irvine ED. A REDCap questionnaire was used to assess descriptive information, self-perceived medical urgency, and PCP Coverage. Chi-Square tests at a 5% significance level were performed to examine differences between race, native language, self-perceived medical urgency, and PCP coverage between preventable and non-preventable ED visits. 

Results
Study participants included 348 adult patients (52% female), of which 160 (46%) were preventable visits (ESI 4-5). There were more preventable visits among Black patients compared to non-Black patients (69.6% vs 30.4%, p=0.028) and the preventable group had less native English speakers than the non-preventable group (38.8% vs 61.2%, p=0.035). Compared to patients in the non-preventable ED visit group, patients in the preventable group are more likely to agree that they could have been seen and treated effectively by a PCP (p=0.003). Fewer patients in the preventable group have a PCP that they can see regularly and make an appointment with compared to the non-preventable group (40.3% vs 59.7%, p=0.004). 

Conclusion
Our results indicate that Black patients and non-native English speakers were overrepresented in preventable ED visits compared to their counterparts, suggesting these patients may be more vulnerable to the plethora of negative consequences associated with utilizing the ED for non-emergent medical services. In addition, our study also revealed that patients in the preventable ED visit group were less likely to have a PCP, even though they were more likely to agree that a PCP could manage their symptoms. Future interventions are needed to address this lack of PCP coverage among preventable ED patients to reduce patient financial burden, ED overcrowding, and overall healthcare spending.

Comparison of Patient Characteristics and Perceived Medical Urgency between Preventable and Non-Preventable Emergency Department Visits

Background
For almost 2 years COVID-19 pandemic has put a myriad of stressors on Health Care Workers (HCW). HCWs were at high risk of exposure to COVID-19. Understanding the factors associated with getting COVID-19 in the hospital setting among the employees are critical to advancing better interventions in the future. 
Methods
Hospital employees who were infected with COVID-19 were assessed in a descriptive study by using IDEA data base and occupational health records in a Large Upper Midwest integrated health system, from March 2019 through June 2020. Categorical variables were analyzed using Chi-squared test (χ2). Logistic regression analysis was performed to explore the risk factors for acquiring the disease. A two-sided P < 0.05 was considered statistically significant. Also, odds ratios (OR) and 95% confidence intervals (95% CI) were carried out for the statistical analysis.
Results
During the period of analysis there were 33175 valid test results among that 2981 (9%) were positive for COVID-19. Majority of employees were Registered Nurses (31.4%). 69.2% employees who reported positive test results had community related exposures while 30.6% had work related exposures. 830 employees who had a positive test result and reported work related exposure had cared for a COVID-19 patient (91.9%). 49 employees had breech to a COVID-19 patient (5.5%) while 99 had a known exposure to a HCW who had COVID-19 (11.1%). Body aches were the primary reported symptom (61.9%, OR=2.703). Some of the other reported symptoms include Loss of smell and taste (59.6%, OR=7.52); Cough (31.2%, OR=2.51); Headache (25%, OR=1.8) and Shortness of Breath (25.4%, OR=1.33). Caring for COVID-19 patients was associated with acquiring COVID-19 (P=0.001, CI=0.058-0.142). Reported breeches from employees were not found to be risk factors for COVID-19 (P=0.25, CI=-0.05-0.00) 
Conclusion
Although work related exposure to COVID-19 was low during the early months of the pandemic, caring for COVID-19 patients identified as a risk factor.

COVID-19 Exposures And Risk for Transmission Among Allina Health Hospital Employees

Background:
The advent of artificial intelligence/machine learning (AI/ML) in medicine has opened opportunities for harnessing the power of ML to predict patient outcomes based on diverse data contained in the electronic medical records (EMR). Taken by themselves singular features represented by such diverse data are often not clearly predictive, but combined in an ML modeling framework such so-called weak learners have the power to yield highly predictive models of health outcomes. 
 
Methods:
We hypothesized that sociodemographic and basic, easily obtainable health characteristics of pregnant mothers strongly predict the risk of rehospitalization.
Using the nuMoM2b dataset from NICHD and reproducible, open access AI/ML techniques we tested and validated this hypothesis. 
 
Results:
Among a large (n=10,038) and geographically diverse cohort of nulliparous women with singleton gestations, the present findings show that while some of these characteristics highlight the known disparities in health outcomes (race/ethnicity), most of them are modifiable through social policies and health counseling. These include access to and support during education, comprehensive health insurance, alleviating coming out of poverty, smoking, and unhealthy lifestyle habits.
 
Conclusion:
Across the four ML models deployed, the results are mutually reinforcing yielding a clear cohesive picture. This solution can be used to develop a prospective risk prediction for this important health outcome in pregnant mothers. The strengths of the presented solution are its focus on preventable maternal morbidities and risk factors, demonstration of the impact on adversely affected populations, and reproducible step-by-step executable, documented open-access code with relatively low computational requirements. This enables easy adoption and further development on this and other similar datasets to study the contributions and predictive power of various factors to maternal morbidities.

Demographic and socioeconomic factors predict maternal postpartum rehospitalization: a retrospective nuMoM2b dataset study

Background: Within New York City (NYC), certain communities have experienced greater rates of adverse COVID-19 outcomes. Current literature has evaluated the effectiveness of public health interventions during COVID-19 but fails to stratify across boroughs with varying demographic makeups. Understanding the effect of COVID-19 on different NYC communities may allow for the development of more efficacious public health policies that address populational disparities. Therefore, we compared trends in COVID-19 cases, hospitalizations, and deaths between the five NYC boroughs before and after the start of vaccine administration, using an interrupted time series analysis.

Methods: Data was collected from the Department of Health and Mental Hygiene’s dataset on daily COVID-19 cases, hospitalizations, and deaths. Our interrupted time series began on June 8th, 2020 and analyzed data through July 3rd, 2021. The intervention in our analysis was the availability of vaccinations to New Yorkers aged 16 years or older, beginning April 6th, 2021. Changes between pre- and post-intervention outcome trends were compared across each of the boroughs.

Results: In NYC as a whole, there was a significant decrease in the trend of cases, hospitalizations, and deaths following vaccinations. The greatest decreases in case trends were seen in the Bronx, Brooklyn, and Queens. Staten Island had a significantly greater decrease in hospitalizations, yet had the smallest change in deaths per unit time. In contrast, Brooklyn had a significantly greater decrease in death trends compared to all other boroughs.

Conclusion: We demonstrate a significant decrease in the trends of cases, hospitalizations, and deaths in NYC following vaccinations, illustrating its effectiveness in mitigating the spread of the pandemic. However, such decreases varied between boroughs, potentially owing to demographic and population-based disparities. Variations in post-intervention death trends may be attributed to Brooklyn’s larger population and a higher percentage of unmet medical care. Furthermore, boroughs with the highest proportion of Black/Hispanic inhabitants and unemployment experienced the greatest rise in pre-intervention death trends. This may indicate a need to target such populations in future public health crises. Nevertheless, boroughs with the highest minority populations showed the greatest decrease in case and death trends, suggesting the vaccine’s effectiveness among underserved populations. 


Differences in the Effectiveness of COVID-19 Vaccine Administration Between the Five New York City Boroughs: An Interrupted Time Series Analysis

Background
Asthma is a chronic respiratory condition affecting around 300 million people worldwide. In North America, the prevalence of asthma in children and young adults is about 11%. Multiple studies have shown that the burden of asthma was higher in the inner-city when compared to non-inner-city areas. In the United States, African and Hispanic Americans have a higher burden for asthma compared to White Americans. The goal of this study was to differentiate the burden of asthma between US-born and foreign-born Black New York City (NYC) residents. 
Methods
This is a secondary data analysis of the 2014 NYC Health and Nutrition Examination Survey (NYC HANES). The covariates of interest are age, sex, education, income, health insurance, and smoking status. We test for differences in asthma among Black residents of NYC by nativity using a multivariable Cox proportional hazard model with robust estimates by using a constant time for cross-sectional studies. We use domain analysis to maintain the complex survey structure of the data. Standard errors were estimated using Taylor’s Series Linearization, accounting for the complex survey nature of the data collection. We conducted all analyses in SAS OnDemand for Academics®. We set the threshold for significance at 5%.
Results
The final analytic sample represented a weighted proportion of 24.16% (SE = 1.40). The proportion of US-born Black residents was 61.1% and the proportion of foreign-born Black residents was 38.9%. Univariate analysis indicated that 29.2% of US-born Black NYC residents reported an asthma diagnosis compared to 10.7% of foreign-born Black residents of NYC (p-value < 0.001). The result of the covariate-adjusted model indicated that foreign-born Black NYC residents had a significantly lower prevalence of asthma compared to US-born (PR = 0.40, 95% CI = 0.21-0.76). Additionally, those who are 65 years and older had a lower asthma risk compared to those 20-34 years old.
Conclusion
This study shows that asthma is found in higher rates amongst US-born Black NYC residents as opposed to foreign-born. Further studies should investigate this result in a national sample. Also, studies should investigate association of acculturation to asthma outcome in foreign-born population.

Disparities in asthma rates amongst Black residents of New York City

Donation Trend from the American College of Physicians and American Academy of Family Physicians Politcal Action Committees: A 2006-2020 Analysis of Partisan Contributions

Abstract Title: Exploration of Exercise Referrals to Personal Fitness Trainers by Primary Care Physicians to Increase Adherence to Exercise Recommendations in African American Women.

Background: The endless health benefits of physical activity are common knowledge, yet physical inactivity is still a public health crisis in the U.S. Increased intervention is necessary to improve adherence to recommendations on physical activity. Adjacent to this crisis, is an increase in patients with obesity. African American women are among those most impacted by obesity and have been found to be the least physically active group in the country. Exercise referrals by primary care physicians to other health care professionals, specifically personal fitness trainers, is one intervention that may increase physical activity. While exercise referrals to personal fitness trainers is an underutilized, understudied intervention in addressing physical inactivity, studies suggest that exercise referrals to personal fitness trainers may have some benefit to African American female women. This study explores how African American women might benefit from exercise referral programs from their primary care physician to personal fitness trainers.

Methods: A literature review was conducted on the value of personal fitness trainers for African American women. One hundred African American women, with a BMI over 30 were surveyed on their physical activity habits and exercise recommendations from their primary care physician, including referral to personal fitness trainers. Survey respondents were offered a $5-$10 gift card for survey completion. Responses were uploaded manually and analyzed using comparison analysis.

Results: Results show that while most African American female patients at the Deighton Family Medicine Clinic reported being advised on physical activity, none had been directed to meet with a personal fitness trainer. 

Conclusion: African American female patients between the ages of 18 and 65 years of age significantly report being advised to exercise by their primary care physician but report no referrals to personal fitness trainers. This study may be useful in influencing interventional programs that refer African American women to personal fitness trainers by identifying barriers and highlighting exercise referrals as an effective therapeutic approach that is not common use.






Exploration of Exercise Referrals to Personal Fitness Trainers by Primary Care Physicians to Increase Adherence to Exercise Recommendations in African American Women.

Background:
Helicobacter Pylori is a gram-negative bacterium that induces chronic gastritis resulting in peptic ulcer disease and can also cause non-ulcer dyspepsia, gastric carcinoma and mucosa-associated lymphoma. Macrolide-based regimens were the first-line treatment for H. Pylori eradication;however, their widespread usage has led to increased resistance and subsequently treatment failure. Other factors contributing include poor compliance, smoking, prior antibiotics exposure.
Methods:
We performed retrospective analysis of electronic medical records of patients who were tested for H. pylori infection between January 2021 to December 2021. Data on patient’s sociodemographic factors, presenting symptoms, tests used for H. Pylori detection (stool antigen vs antibodies), prior use of antibiotics, the first line regimen used to treat the infection and follow up to confirm eradication of infection, were collected. Frequencies for all variables were calculated.
Results:
Among cohort of 670 with mean age of 57.9, 58% were females, 23% were of Hispanic ethnicity and 14% were former smokers, majority of cohort got tested in the ambulatory settings (75%) using stool antigen test 93% of which 37% (n= 234) tested positive for H. pylori and among these 53% were using PPI. The most common presenting symptoms were abdominal pain (64%) and GERD (22%), respectively. Standard triple regimen consisting of clarithromycin, amoxicillin, and PPI were prescribed to 76.1% of positive tested individuals with only 50%
completed the therapy and 28% of these had eradication confirmation on repeat stool antigen testing at a median follow-up of 12.7 weeks.
Conclusion:
Macrolide resistance, particularly for clarithromycin, has been observed at varying rates (1-21%) across different geographical regions and is now considered as an important factor in eradication failure. In our study we observed a low eradication rate among patients who were treated with macrolide-based regimen as first line therapy, suggesting that macrolide resistance may have played a role in eradication/treatment failure apart from other factors i.e., cost, duration of
therapy, poor compliance and loss of follow up. Thus, use of bismuth-quadruple or levofloxacin based regimen as first line therapy in high macrolide resistance areas is warranted.

Factors for H. Pylori Eradication Failure and Regimen Conformity withStandard Guidelines.

Introduction: Although the high rates of mental health issues and the unmet healthcare needs among Asian Americans have been recognized in literature, there is a lack of empirical research on the mental health issues of Filipino Americans (FAs). Using data from a mixed method study that integrated a quantitative survey with qualitative interviews, this study explored factors that influence mental health needs and access to care in FAs living in Eastern Virginia.

Methods: A Community Health Resources and Needs Assessment (CHRNA) survey was implemented online using REDCap and distributed to Asian and Pacific Islanders in Eastern Virginia in April-July 2022. Participants (N=1,462) were recruited through in-person events and social media channels using three sampling criteria: 1) persons of Asian and Pacific Islander descent, 2) ages 18-85 years, and 3) residents of Hampton Roads and the Eastern Shore. Data from a subsample of 281 respondents who self-reported as Filipino were analyzed using descriptive statistics and multivariable logistic regression. Key informants (N=25, including 15 females and 10 males) were recruited through snowball sampling and referrals from Filipino community stakeholders. Semi-structured interviews (30-60 minutes) were conducted virtually via Zoom in English by trained researchers. Semantic analysis was guided by the grounded theory and the socio-ecological model.

Results: While 7.2% of FAs received diagnoses of depression or other mental health problems from healthcare providers, 27.4% frequently experienced the following: 1) had little interest or pleasure in doing things, 2) felt down, depressed, or hopeless; 3) feeling nervous, anxious or on edge; 4) being unable to stop or control worrying. Higher odds of having mental health issues were found in females, older participants, participants who experienced language barriers, and participants with less economic resources. Religious belief (e.g., Catholicism) and family support served as significant buffers for FAs to cope with stress. Stigma embedded within Filipino culture has been a key mental health barrier in FAs. While the Philippine Cultural Center (PCC) has served as a primary source of community support (particularly for the elderly population), the PCC could be further utilized as a community-based mental health resource, involving licensed mental health practitioners for culturally sensitive interventions in a community setting.

Conclusion: Findings demonstrate that FA mental health is influenced by a complex interplay of macro and micro-level socio-ecological factors. Culturally competent community-based interventions are urgently needed to normalize mental health, to increase awareness and access to care, and to reduce mental health issues and disparities.

Factors Related to the Mental Health of Filipino Americans in Eastern Virginia - Findings from a Mixed Methods Study Conducted in 2022

Though originally designed in the 1960s to provide emergency medical care, emergency medical service (EMS) systems have experienced non-emergency utilization by small groups of frequent EMS users. Frequent EMS use as a public health issue reflects healthcare waste, misused EMS resources, and underserved populations. In turn, municipalities such as San Francisco have developed community paramedicine (CP) programs to improve access to healthcare and social services in non-emergency settings. Prior evaluation has found that EMS-6 — one such CP program operated by the San Francisco Fire Department (SFFD) — is safe and effective at reducing frequent EMS use amongst the most frequent EMS users. That said, frequent EMS users are heterogeneous groups with diverse needs, such as housing assistance, primary care, urgent care, and detoxification. The goal of this in-progress study is to describe the characteristics of frequent EMS users in San Francisco over recent years. By characterizing those frequent EMS users who have not experienced decreases in frequent EMS use, the results may be used to inform adjustments to the CP services provided by EMS-6.

Downloads

Next from AMA Research Challenge 2022

Comparison of Patient Characteristics and Perceived Medical Urgency between Preventable and Non-Preventable Emergency Department Visits

Similar lecture

Promoting Cybersecurity Culture Change in Healthcare