United States

Introduction: Obesity is an increasingly prevalent comorbidity that confers greater risks of postoperative complications following total joint arthroplasty, underscoring the need for viable preoperative weight loss. The objective of this study was to compare the risk of 90-day adverse events in patients undergoing total knee arthroplasty (TKA) following bariatric surgery versus treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RA).

Methods: A retrospective review of a national research network from May 1, 2005, to February 12, 2025, identified patients undergoing TKA with bariatric surgery or GLP-1 RA prescriptions in the 18 months preceding their joint arthroplasty. Following propensity score matching, 4,652 patients were selected for comparison in both the bariatric surgery and GLP-1 RA cohorts. For each cohort, patient demographics, 90-day orthopaedic and surgical complications, readmissions, and emergency department (ED) visits were collected. Statistical differences in relative risk (RR) between each complication were calculated with t-tests and Chi-square tests. 

Results: In the 90-day postoperative period, patients who underwent bariatric surgery before TKA experienced greater rates of periprosthetic fractures (RR: 2.4; P = 0.016), periprosthetic joint infections (RR: 1.7; P = 0.002), revision surgeries (RR: 1.926; P = 0.005), cardiac events (RR: 1.255; P &lt; 0.001), readmissions (RR: 1.316; P = 0.015), and ED visits (RR: 1.2; P &lt; 0.001). 

Conclusion: A significantly increased risk of postoperative events was identified in patients who underwent bariatric surgery. These findings, along with existing literature, suggest that GLP-1 RA use may be a preferred option for preoperative weight loss optimization in TKAs. Overall, greater clinical understanding is provided for this drug and may inform surgical decision-making regarding weight management strategies and their associated risks.

AMA Research Challenge 2025 

Short-Term Complications After TKA in Patients with Prior Bariatric Surgery or GLP-1 Agonist Use

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Introduction: Obesity is an increasingly prevalent comorbidity that confers greater risks of postoperative complications following total joint arthroplasty, underscoring the need for viable preoperative weight loss. The objective of this study was to compare the risk of 90-day adverse events in patients undergoing total knee arthroplasty (TKA) following bariatric surgery versus treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RA).

Methods: A retrospective review of a national research network from May 1, 2005, to February 12, 2025, identified patients undergoing TKA with bariatric surgery or GLP-1 RA prescriptions in the 18 months preceding their joint arthroplasty. Following propensity score matching, 4,652 patients were selected for comparison in both the bariatric surgery and GLP-1 RA cohorts. For each cohort, patient demographics, 90-day orthopaedic and surgical complications, readmissions, and emergency department (ED) visits were collected. Statistical differences in relative risk (RR) between each complication were calculated with t-tests and Chi-square tests. 

Results: In the 90-day postoperative period, patients who underwent bariatric surgery before TKA experienced greater rates of periprosthetic fractures (RR: 2.4; P = 0.016), periprosthetic joint infections (RR: 1.7; P = 0.002), revision surgeries (RR: 1.926; P = 0.005), cardiac events (RR: 1.255; P < 0.001), readmissions (RR: 1.316; P = 0.015), and ED visits (RR: 1.2; P < 0.001). 

Conclusion: A significantly increased risk of postoperative events was identified in patients who underwent bariatric surgery. These findings, along with existing literature, suggest that GLP-1 RA use may be a preferred option for preoperative weight loss optimization in TKAs. Overall, greater clinical understanding is provided for this drug and may inform surgical decision-making regarding weight management strategies and their associated risks.

poster

Background 

The right atrioventricular (tricuspid) valve (RAV) separates the right atrium and ventricle to inhibit retrograde blood flow during ventricular systole. Although traditionally described as having three leaflets — anterior, posterior, and septal — it is not uncommon for the RAV leaflet number to vary with previous studies finding three leaflets in 28% to 71.1%, four leaflets in 28.9% to 52%, and as few as 2 and as many as 6 have been documented. An understanding of RAV functional morphology is essential for successful transcatheter tricuspid valve repair (TTVR) procedures for the treatment of tricuspid regurgitation. Although less common than mitral valvular disorders, tricuspid regurgitation has been shown to correlate with poor cardiac sequela and increased cardiac mortality, leading to increasing incidence of TTVR procedures. This ongoing study explores the prevalence of variation in RAV leaflet numbers using cadaveric donors at Midwestern University to contribute to the understanding of its morphology and implications for TTVR. 

Methods 

Thirty-seven cadaveric donor hearts consisting of 19 males and 18 females were examined and classified according to the schema—Type 1 (three leaflets), Type 2 (two leaflets), and Type 3 (four leaflets). The presence of a fourth leaflet was further subdivided based on additional leaflet location—type 3A (anterior), 3B (posterior), and 3C (septal). Individual leaflets were defined during dissection as existing within a distinct gross margin of the valve and having unique papillary muscle attachments. This procedure allowed us to distinguish discrete additional leaflets from commissural leaflets that exist between two leaflet margins but function in tandem with a single leaflet. 

Results 

This study found that of the 37 hearts, 29 (78.4%) were Type 1, three (8.1%) were Type 2, and five (13.5%) were Type 3. Of the Type 3, one was Type 3A (2.7%), two were Type 3B (5.4%), and two were Type 3C (5.4%). 

Conclusion 

This study found lower frequencies of a fourth leaflet than previous studies. However, the findings of these studies vary widely, primarily due to procedural differences in defining and distinguishing leaflets from commissural leaflets arising from a lack of universal naming protocols. Regarding TTVR, the presence of a fourth RAV leaflet is clinically significant as it is associated with increased residual regurgitation following procedure in those treated for isolated tricuspid regurgitation. These preliminary data contribute to the growing understanding of RAV morphology, which has the potential to contribute to current and future advancements in the treatment of tricuspid regurgitation.

Anatomical Variation in Cadaveric Tricuspid Valves and Implications for Transcatheter Tricuspid Repair

Background
Adefovir dipivoxil (ADV) is an antiviral nucleotide analog used clinically to treat hepatitis B that was found to have nephrotoxic effects when used at higher doses to treat human immunodeficiency virus. This effect is hypothesized to result from inhibition of mitochondrial DNA replication in the nephron. ADV also promotes the expression of CCAAT-enhancer-binding protein-β (C/EBPβ) target genes involved in fatty acid oxidation in mitochondria and prevents diet-induced obesity in mice, though the mechanisms are currently unclear. Free fatty acids are toxic to pancreatic β cells and thus important in the development of type 2 diabetes mellitus. We hypothesize that ADV can protect against fatty acid toxicity in pancreatic β cell lines and increase insulin secretion through mitohormesis.

Methods
Immortalized β cells were treated with increasing levels of ADV and palmitic acid and evaluated for toxicity and mitochondrial function via flow cytometry, insulin secretion via ELISA, and mitochondrial morphology via microscopy (no palmitate was given with this method).

Results
We found that insulin secretion was increased in cells treated with ADV compared to those without ADV treatment at no palmitate levels. Our research also revealed that ADV protects against fatty acid toxicity, with the least cell death seen in cells treated with ADV at maximum palmitate concentrations. Finally, we found that mitochondrial function, as quantified by TMRE fluorescence to MitoTracker Deep Red fluorescence ratio, was highest in cells treated with ADV at all concentrations, regardless of palmitate concentrations. For mitochondrial morphology, qualitatively, cells treated with ADV appeared to have more punctate mitochondria than those without ADV treatment; this phenomenon is consistent with prior observations in other cell types. 

Conclusion
These data show that ADV can protect against fatty acid toxicity and increase insulin secretion in pancreatic β cells, potentially through mitohormesis. We hypothesize that ADV treatment may have this effect by promoting mitophagy, given the findings of punctate mitochondria, though this requires further investigation. This drug can elucidate the role of mitochondria in the pathogenesis of type 2 diabetes mellitus, which may lead to new understandings and therapeutic approaches for one of the most widespread chronic diseases in the United States.

Protective effects of adefovir dipivoxil in pancreatic β cell lines

Background: GBM, WHO grade IV, is classified transcriptionally into three subtypes: proneural, mesenchymal, or classical. High grade gliomas have been shown to demonstrate high intratumoral heterogeneity, which promotes an environment conducive for plasticity and selection. PDGFRA is amplified in 14% of newly diagnosed GBM studied by The Cancer Genome Atlas. Assaying different subpopulations from the same tumor, our objective was to characterize the genetic programs associated with the presence and absence of PDGFRA ecDNA.

Methods: To identify gene signatures associated with negative and positive selection of PDGFRA, we performed droplet-based single-cell RNA sequencing (Chromium Next GEM Single Cell 3’ v3 library (10X Genomics, Pleasanton, CA)) on 4 distinct populations from a patient-derived model, HF3253. Data preprocessing was conducted in Cell Ranger and Seurat. After filtering cells with greater than 10% mitochondrial content, 27,842 cells were subjected to canonical correlation analysis and assessed by Loupe, AUCell, and CellChat.

Results: Gene signatures for all three subtype signatures were present in distinct clusters in the mosaic projection derived from the 4 unique subpopulations. Unexpectedly, a 24-gene mesenchymal signature was enriched in 70% of the assayed cells (AUC = 0.056). This enriched signature was present in almost 47% PDGFRA-expressing cells (log > 1) and was also well- represented in a literature-based dataset. In addition to this signature, PDGFRA+ cells were identified as endothelial and vascular leptomeningeal cells (VLMC, brain fibroblast). PDGFRA transcript was virtually absent in microglial-like cells. Cell-cell communication inference classified the VLMC population as the dominant signaling node, modulating both incoming and outgoing signals. We next mapped the top 50 most significant differentially expressed genes associated with PDGFRA ecDNA loss from bulk RNA sequencing to our single-cell data. These unique clusters were highly enriched in neurodevelopmental cell types (oligodendrocyte precursor cells, oligodendrocytes, astrocytes). Specifically, 37% of the total cell population highly expressed a 103-gene signature for mature astrocytes (AUC = 0.17).

Conclusion: PDGFRA amplifications have traditionally been classified as a driver of an OPC- like gene program in GBM. Our identification of a fibroblast-like gene program in PDGFRA ecDNA+ cells challenges the notion that tumor drivers have a definitive cellular program and hypothesizes that GBM tumor evolution can be attributed to oncogene-driven plasticity. As mesenchymal transition is a predominant evolutionary mechanism in recurrent GBM specimens, our work validates PDGFRA as a therapeutic target following early tumor progression. Loss of PDGFRA in our model appears to promote cell differentiation associated with normal neurodevelopmental trajectories.

Characterization of glioblastoma (GBM) transcriptional heterogeneity in a patient derived platelet derived growth factor receptor alpha (PDGFRA) extrachromosomal DNA (ecDNA) amplified model

Background
The Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) was created with the goal of quality improvement in bariatric surgery. Centers with MBSAQIP accreditation report outcomes to a national database. Staple line bleeds are a primary cause of postoperative hemorrhage in vertical sleeve gastrectomy (VSG). Review of our institution’s MBSAQIP semiannual report noted higher instances of reoperations following laparoscopic. This study sought to standardize practice across surgeons and reduce reoperation for bleeding following VSG.

Methods
Using the Plan, Do, Study, Act framework, two review periods were determined. Pre-intervention, surgeons used a hybrid robotic-laparoscopic approach to VSG in which the dissection was performed with the robot and a laparoscopic stapler was used to complete the sleeve. The intervention included standardizing an entirely robotic approach. A peer review and manufacturer recommendation from Covidien were used to develop our technique using 1-2 blue loads based on tissue thickness and feedback from the robot followed by white loads to complete the sleeve.

Results
Pre-intervention, 5/107 cases (4.67%) required reoperation with 80% due to staple line bleeds (3 hybrid technique and 1 robotic sleeve). Post-intervention, 1/56 VSG required reoperation for bleeding on a laparoscopic VSG. There were zero postoperative bleeding episodes for fully robotic sleeves. Sixty-nine percent of robotic cases used additional interventions (clips or oversewing staple lines at the index operation), and 31% did not require additional intervention. 

Conclusion
Standardizing robotic VSG decreased re-operations for bleeding. Reinforcement of robotic staple lines was performed in most cases and likely contributed to the reduction. Future work should consider standardizing reinforcement techniques or using reinforced stapler loads.

Vertical Sleeve Gastrectomy Stapler Length – Quality Improvement Project

Background
Cervical disc degeneration is a condition that significantly diminishes a patient’s quality of life. It is commonly treated with surgical interventions such as anterior cervical discectomy and fusion (ACDF) or cervical disc arthroplasty (CDA). Obesity, an ever-growing global public health concern, introduces unique challenges to spinal surgery due to its detrimental effects on biomechanical stress, wound healing, and recovery. Even with recent advancements in surgical techniques, the literature regarding how obesity affects the outcomes in ACDF vs CDA is limited. Therefore, the objective of this study is to compare clinical outcomes, functional recovery, and complication rates of CDA and ACDF in obese adults to provide evidence-based insights that can guide clinical decision-making for this high-risk population.

Methods
A retrospective database analysis was conducted using the multi-institutional database TriNetX, on the research network, wherein we looked at adult (>18 y/o) obese (>30 BMI) versus non-obese patients (18-29 BMI) undergoing ACDF vs CDA. Propensity score matching was done to ensure balanced demographic and clinical characteristics, which generated 26,272 patients for the 90-day analysis and 2,269 patients for the 2-year analysis in the obese ACDF group, and 2,270 patients for the 90-day analysis and 2,269 patients for the 2-year analysis in the obese CDA group. Our primary outcomes included functional improvement measured by the neck disability index (NDI), composite success, as well as readmission rates. Secondary outcomes included infections, deep vein thrombosis (DVT), cerebrospinal fluid (CSF) leak repairs, mechanical complications, adjacent segment disease, and cervical herniation. Risk ratios (RRs) and statistical significance (p < 0.05) were calculated to compare the two cohorts.

Results
Obese patients that underwent CDA were associated with significantly lower 90-day readmission rates (RR: 0.79; p < 0.001), fewer 2-year readmissions (RR: 0.58; p < 0.001), and improved functional outcomes, including composite success and Neck Disability Index scores (p < 0.001). CDA also demonstrated trends toward fewer infections, adjacent segment disease, and deep vein thrombosis, though these differences were not statistically significant. Mechanical complications and cervical herniation rates were comparable between the two groups. 

Conclusion
In obese patients, CDA demonstrated better functional recovery and lower readmission rates compared to ACDF, with comparable complication rates. Our findings support that CDA may be a more viable option for managing cervical disc degeneration in this vulnerable population.

Cervical Disc Arthroplasty vs. Anterior Cervical Discectomy and Fusion in Obese Patients: 90-Day and 2-Year Outcomes

Introduction: Inhaled triple therapy is a combination of an inhaled corticosteroid (ICS), long-acting beta agonist (LABA), and long-acting muscarinic antagonist (LAMA), and is used to treat chronic obstructive pulmonary disease (COPD). This therapy is indicated in GOLD class E patients – those with ≥2 moderate COPD exacerbations or ≥1 leading to hospitalization. ICS in these groups reduces exacerbations and improves lung function and patient reported outcomes. ICS benefits decrease with serum eosinophil count <100 cells/uL and increase with counts ≥300 cells/uL. However, ICS therapy has been associated with a higher incidence of pneumonia, especially in those with frequent or severe COPD exacerbations and blood eosinophils <2%.

Methods: This retrospective cohort study evaluated inhaled triple therapy prescribing practices and subsequent pneumonia incidence in patients with COPD located in rural Indiana between January 1, 2020, and January 1, 2025. A query of the electronic medical record system Epic was done to assess if ICS addition met guideline-based indications (GOLD class E criteria, defined as ≥2 moderate exacerbations or ≥1 exacerbation requiring hospitalization in the prior year) and to record serum eosinophil count prior to initiation. To evaluate subsequent pneumonia incidence, participants were stratified according to eosinophil count – ≤100 cells/uL, 101-299 cells/uL, and ≥300 cells/uL. Chi-square tests were used to compare categorical variables. Logistic regression was used to determine odds ratios adjusted for GOLD indications for triple inhaler therapy. Statistical significance was defined as p ≤0.05.

Results: Among 227 patients prescribed triple inhaler therapy, 36.5% met GOLD class E criteria for initiation. Pneumonia incidence the following year was increased in those with serum eosinophil count ≤100 cells/µL, whereas higher eosinophil count ≥300 cells/uL was associated with a decreased incidence of pneumonia, though these trends were insignificant. Stratifying according to exacerbation severity & frequency and GOLD grade did not yield statistically significant associations. There was no confounding based on GOLD grade or exacerbations.

Conclusion: In this rural Indiana cohort, a substantial proportion of patients receiving triple inhaler therapy did not meet guideline-based indications for ICS initiation. Though lower eosinophil counts were associated with increased pneumonia incidence, these findings did not achieve statistical significance. Further investigation using a larger patient population is required to further delineate the relationship between eosinophil count and risk of pneumonia after initiating triple inhaler therapy.

Prescribing Practices of Inhaled Triple Therapy in Rural Indiana​

Background
The standard of care for localized renal carcinoma is nephrectomy, but this procedure carries a risk of complications like chronic kidney disease (CKD) and end-stage renal disease (ESRD). Current predictive models for these outcomes are limited by the underrepresentation of Black patients and do not investigate how racial differences are mediated. This project aims to identify which treatment decisions might be impacted by race and to use causal inference to investigate whether those treatment differences impact outcomes.

Methods
A cohort of 2,931 patients who underwent nephrectomy were identified from University of Florida medical records, including 489 (17%) Black patients. After filtering, the analysis cohort consisted of 2,571 patients (948 partial vs. 1,623 radical nephrectomy). A causal forest model was used to determine the average (ATE) and conditional (CATEs) treatment effects of partial versus radical nephrectomy on ESRD development. Logistic regression determined the association between race and both treatment type and ESRD outcomes after controlling for clinical variables. As race is not a manipulable variable, it was included as a covariate in the causal forest to explore heterogeneity in treatment effects across racial subgroups.

Results
Surprisingly, after adjusting for other factors, Black patients had 1.36 times the odds of receiving a partial nephrectomy compared to White patients (95% CI: 1.197, 1.554). However, Black patients still had 1.30 times the odds of developing post-nephrectomy ESRD (95% CI: 1.026, 1.646). While patients who received a radical nephrectomy developed ESRD at a higher raw rate than those who received a partial nephrectomy (4.5% vs 2.5%), the causal forest model found no statistical significance after accounting for patient characteristics (ATE: 0.011; 95% CI: -0.046 to 0.069; p=0.703). This indicates the difference may be explained by clinicians’ patient selection. The suitability of the data for this analysis was demonstrated by good overlap in propensity scores between treatment groups and balanced covariates.

Conclusion
These findings suggest that Black patients are more likely to receive a partial nephrectomy, yet still have a higher risk of developing ESRD post-operatively. This highlights a significant racial disparity in outcomes that is not explained by surgery type alone. Additionally, the lack of a clear causal link between nephrectomy type and ESRD calls into question whether the differences in post-nephrectomy ESRD are due to surgeons choosing healthier patients for partial instead of radical nephrectomy.


Addressing Racial Disparities with Causal Forests: Black Race is Associated with more Post-Nephrectomy End-Stage Renal Disease, but Nephrectomy Type is not a Causative Factor

Abstract Title
Adult Rectal Duplication Cyst Presenting as Chronic Back Pain
Background
Alimentary tract duplications are rare congenital anomalies with an incidence of approximately 1
in 4,500 live births. They are most commonly identified in infancy or childhood. Rectal
duplication cysts (RDCs), a particularly uncommon subtype, account for just 1%-6% of all
alimentary tract duplications. These lesions typically present as cystic structures containing
layers of gastrointestinal wall histology. While often asymptomatic, their presentation can vary
significantly depending on patient age. In children, RDCs may present as bowel obstruction,
recurrent perianal infections, or be discovered on physical examination. In contrast, adults may
present with vague or unrelated symptoms, found incidentally on imaging. In rare cases, RDCs
may become symptomatic due to compression of adjacent structures, infection, fistula
formation, or even malignant transformation. Given their deep pelvic location and nonspecific
symptomatology, they are often misdiagnosed or overlooked. Reports of RDCs in adults are
rare, and their varied presentation poses significant challenges in diagnosis and management.
We present the case of an adult woman who presented with chronic back pain and was found to
have an RDC, emphasizing the importance of considering congenital anomalies in the
differential diagnosis of pelvic masses in adults.
Case Presentation
A 41-year-old female presented with a five-year history of low back pain radiating to both legs,
initially attributed to lumbar radiculopathy. She denied gastrointestinal or urinary symptoms. On
physical examination, a firm mass was palpated posterior to the rectum. Pelvic MRI revealed a 7
cm heterogenous mass in the presacral space. CT showed the posterior pelvic mass abutting
the distal coccyx without involving the sacrum. Given the concern for malignancy, she
underwent robotic-assisted laparoscopic resection. Intraoperatively, a 5-6 cm well-encapsulated
presacral mass was identified and excised via a Pfannenstiel incision. She was discharged
home the same day without complications. Histopathologic analysis revealed squamous
epithelium overlying smooth muscle and connective tissue, consistent with a benign rectal
duplication cyst.
Discussion
Adult RDCs are rare and often present with nonspecific symptoms, making diagnosis difficult.
MRI is preferred for soft tissue evaluation, while CT can assess for bony involvement. Complete
surgical resection remains the definitive treatment and diagnostic modality. Robotic resection
offers superior visualization with improved post-operative pain. This case emphasizes the need
to include RDCs in the differential diagnosis of chronic pelvic or back pain in adults.

Adult Rectal Duplication Cyst Presenting as Chronic Back Pain

Background
TikTok, a popular social media platform for short-form mobile videos, provides a source for individuals to share and receive information regarding permanent sterilization methods. TikTok has become the primary source for young adults to receive a majority of their daily information, including contraceptive health information among young women. While TikTok has become beneficial in connecting individuals with shared concerns, users can also be exposed to significant misinformation.
Methods
101 TikTok videos under #tubal, #tuballigation, and #tubestied were collected using Apify web-scraping software for analysis. Each video was evaluated for creator demographics, tonality, and medical content by two separate reviewers, a third reviewer mediating discrepancies in assessment. DISCERN and PEMAT (Patient Education Materials Assessment Tool) criteria were used to evaluate the quality and accuracy of medical information presented through the TikTok videos regarding tubal ligation. DISCERN scores range from a low of 1 and a high of 5 regarding medical information quality. PEMAT scores range from 10%-100% and evaluate the understandability of patient education audiovisual materials.
Results
Results indicated that video tonality was split between positive (32.7%), negative (31.7%), and neutral (27.7%). While 25.7% of the videos explicitly referenced a negative experience with female permanent contraception a majority did not, with 5.9% mentioning both a positive and negative experience. 16 videos (15.8%) explicitly focused on failure of the tubal ligation procedure resulting in unexpected pregnancy. Of the 28.7% of videos showcasing a personal experience, changes in menstruation, hormones, and increased pain and cramping were highlighted as notable and debilitating side effects, with the colloquial term “post-tubal syndrome” emerging among women. Only a minority of videos were created by healthcare professions (24.8%), and among those, most (80%) were board certified Obstetric Gynecologists who often shared content regarding the logistics of procedures, risks, complications, and outcomes. Of the 15 videos containing medical content created by healthcare professionals the average DISCERN score was 3.8 compared to a score of 3 by laypeople (n=22). The average PEMAT score for videos with medical content was 84.2%, higher among healthcare professionals (93.3%) than lay people (81.8%). 
Conclusion
#tuballigation, #tubal, and #tubestied videos on TikTok commonly showcase negative experiences and failed procedures resulting in pregnancy through the sharing of individual’s personal experiences as well as content regarding procedural logistics and sterilization education from healthcare professionals. Qualified health professionals may consider utilizing TikTok as a platform to effectively share credible medical knowledge regarding female permanent contraception, as many individuals seek and obtain health information from the platform. Awareness of the content patients consume can help healthcare professionals address misinformation and guide informed medical decision-making. 



Use of TikTok as a Source of Medical Information Regarding Tubal Ligation

Intimate Partner Violence (IPV) is a significant public health concern that remains insufficiently addressed in medical education. A national survey indicates that nearly one in two women (47.3%) and more than 40% of men (44.2%) in the United States have experienced IPV in their lifetime. Despite the high prevalence and serious health implications of IPV, comprehensive training on this topic has not been widely incorporated into medical school curricula. Current research shows integrating interactive simulations into medical school curriculum is the best practice for providing lasting knowledge on the training topic at hand. This study aims to bridge the educational gap of IPV in medical students by implementing an interactive, simulation-based curriculum. This will not only enhance future physicians' competency in recognizing IPV but also equip them with the skills to provide appropriate resources to victims. Participants will engage in a structured training session, featuring a role-playing exercise and guided case discussions. A pre- and post-survey model will be used to assess changes in knowledge, confidence, and attitudes toward IPV management. Preliminary data has demonstrated statistically significant improvements in both preparedness and knowledge among participants following the intervention. These preliminary findings suggest the intervention was effective in enhancing medical students’ confidence and understanding related to identifying and managing intimate partner violence in clinical settings. Additionally, initial data suggests students feel more adequately equipped with practical tools for screening and intervention, alongside a heightened sense of empathy, compassion, and understanding of IPV victims - an essential step in providing trauma-informed, supportive care. Notable limitations of this study include the immediate timing of participant responses, which may have been influenced by the emotional impact of the intervention, as well as a small final sample size (n=20). Although 59 participants completed the pre-survey, only 24 completed the post-survey, and just 20 submitted fully completed responses. This low yield of responses raises concerns about feasibility and integration of such a curriculum within an already demanding medical school schedule. Alongside a larger sample size, longitudinal investigation of participants would be needed to assess efficacy of the curriculum in clinical practice. However, by implementing a curriculum that is interactive and attitudinally transformative, we aim to bridge the existing educational gap and, ultimately, provide more comprehensive patient care in clinical practice.

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Anatomical Variation in Cadaveric Tricuspid Valves and Implications for Transcatheter Tricuspid Repair

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