Czechia

Thrombosis and thromboembolic complications are the dominant pathology in the general structure of mortality and mortality in the adult population. For this reason, the development of new potential drugs with antithrombotic effects with a low risk of side effects is one of the promising areas of modern science.

SEB Conference 2024

Preclinical evaluation of the effectiveness of antithrombotic drugs

### Conference Welcome

Welcome to the third Cultural Evolution Society Conference, CES2021. In the conference, which will be held from June 9-11, 2021, about 180 researchers from East Asia, Oceania, Middle East, Europe, North and South America give presentations on their latest research advancing the evolutionary understanding of human and nonhuman animal culture.

### Schedule and Program

[![](https://assets.underline.io/uploads/markdown_image/1/image/1ef06ffd05f80957b4a5b685f63ee3ba.png)](https://www.chain.hokudai.ac.jp/CES2020/wp-content/uploads/2021/06/fullprogram.pdf)
[![](https://assets.underline.io/uploads/markdown_image/1/image/12285eb22580949635121d15d5b46325.png)](https://www.chain.hokudai.ac.jp/CES2020/wp-content/uploads/2021/06/abstracts.pdf)

**Program-at-glance**

![](https://assets.underline.io/uploads/markdown_image/1/image/c0d0d4c8fcdad49d12631574fd966ae8.png)

### About the conference 
 
**Help-desk:** 
Please first visit [Help-desk](https://underline.io/events/120/help-desk) where you can find the instructions and manuals for exploring the conference site. 

**Plenary sessions:**
Five leading researchers give a live talk. It is like a TV show. The audience can submit a question from the chat window. Chat messages are immediately delivered to speakers and moderators.

**Q&A sessions (parallel):**
Each presenter first gives a 2-minute live lightning talk followed by an 8-minute live discussion with the audience. It uses Zoom.

**Discussion sessions:** 
The audience can approach presenters and discuss their research. The sessions are held in a dedicated room in Gathertown.
 
**Gathertown:**
It is a platform dedicated to live virtual interactions.
Gather Town is available for all participants 24 hours during the conference.
You can meet and talk with anybody at a lounge or at a table in Gathertown.
Further Gather Town instruction and how to use short keys please find in our [Help desk page](https://underline.io/events/120/help-desk). 

**Videos and slides:**

* Plenary sessions and the Q&A sessions will be recorded and uploaded after the sessions.
* All the videos and slides are available for 60 days after the conference but only to registered ones. 

**Text-based chatting with the speakers:** 
You can chat with any speaker in the Q&A and discussion sessions. A chat window is available on each speaker’s page, and you can leave your questions there. 

**Announcement to the other participants:**
If you want to make an announcement to the other participants (e.g., “Hey, let’s meet at the lounge in Gathertown from 9pm CEST!), please use twitter (#CESConf2021).



### Code of conduct

See the full details of [the code of conduct](https://www.chain.hokudai.ac.jp/CES2020/code-of-conduct/).
&nbsp; 
 CES is dedicated to providing a welcoming and harassment-free conference experience for everyone, regardless of gender, gender identity and expression, sexual orientation, disability, physical appearance, body size, race, age, religion, nationality, or the presence of or care for dependents. 
We do not tolerate harassment of conference participants in any form. Conference participants violating these rules may be sanctioned or expelled from the conference at the discretion of the conference organizers.

&nbsp;
**Harassment can occur in-person or virtually, and includes, but is not limited to:**
* Comments (verbal, text, etc.) that reinforce social structures of domination related to gender, gender identity and expression, sexual orientation, disability, physical appearance, body size, race, age, religion, nationality
* Sexual images in public spaces (physical or virtual)
* Deliberate intimidation, stalking, or following
* Harassing photography or recording (including sharing of presentation materials without consent)
* Sustained disruption of talks or other events (including “Zoombombing”)
* Inappropriate physical contact or unwelcome sexual attention
* Advocating for, or encouraging, any of the above behaviour 

&nbsp;
 **Inclusiveness Committee**:
&nbsp;
 To facilitate implementing the code of conduct and foster a climate of inclusion, we have developed an inclusiveness committee. Below is their contact information:
 **Hiromi Matsumae**:	matsumae.hiromi.g@tokai.ac.jp
 **Patrick Savage**:	psavage@sfc.keio.ac.jp
 **Sarah Mathew**:	Sarah.Mathew@asu.edu
 **Gmail:** inclusivenessCES2021@gmail.com
 See [more details about reporting the harassment.](https://www.chain.hokudai.ac.jp/CES2020/code-of-conduct/)

### Organizing committee

**Honorary Conference Organizer:** [Kenichi Aoki (Meiji University)](https://sites.google.com/site/kenichi1aoki/home) 

**Chair:** [Masanori Takezawa (Hokkaido University)](https://lalalarakko.github.io)

**Scientific Committee:** [Kenichi Aoki (Meiji University)](https://sites.google.com/site/kenichi1aoki/home), [Yasuo Ihara (the University of Tokyo)](https://researchmap.jp/read0209180?lang=en), [Hiromi Matsumae (Tokai University)](https://sites.google.com/site/hiromimatsumae/eng), [Naoko Matsumoto (Okayama University)](https://researchmap.jp/nmatsumoto_okayama-u), [Masako Myowa (Kyoto University)](https://myowa.educ.kyoto-u.ac.jp/en), [Hisashi Nakao (Nanzan University)](https://www.hisashinakao.com/), [Patrick E. Savage (Keio University)](https://sites.google.com/view/comp-music-lab/home)

**Local Organizing Committee:** [Yutaka Horita (Teikyo University)](https://sites.google.com/site/yhoritapage/), [Masanori Takezawa (Hokkaido University)](https://lalalarakko.github.io/), [Ayaka Takimoto (Hokkaido University)](https://lynx.let.hokudai.ac.jp/~takimoto/), [Kohei Tamura (Tohoku University)](https://researchmap.jp/7000017854)

**Inclusiveness Committee:** [Sarah Mathew (Arizona State University)](https://www.sarahmathew.net/), [Hiromi Matsumae (Tokai University)](https://sites.google.com/site/hiromimatsumae/eng), [Patrick E. Savage (Keio University)](https://sites.google.com/view/comp-music-lab/home)


![](https://assets.underline.io/uploads/markdown_image/1/image/967110a00d200a6b20d6f4fa6556ba13.png)

For attending the conference, you first need to register and pay fees from [the link here](https://www.chain.hokudai.ac.jp/CES2020/registration/). After the payment of the registration fees, you will receive a ticket, which is necessary for accessing the conference site. After the payment of the registration fees, you will receive a ticket, which is necessary for accessing the conference site

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Cultural Evolution Society 2021

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SEB’s Annual Conference is celebrated for creating the perfect composition of research, new discoveries and collaborative connections. Be creative and innovative by exchanging ideas and knowledge with masters of biology from all over the world.

In a 10-month experimental study, we assessed the combined impact of warming and acidification on critical life stages of small-spotted catshark (Scyliorhinus canicula). Using recently developed frameworks, we disentangled individual and group responses to two climate scenarios projected for 2100 (SSP2-4.5: Middle of the road and SSP5-8.5: Fossil-fueled Development). Seasonal temperature fluctuations revealed the acute vulnerability of embryos to summer temperatures, with hatching success ranging from 82% for the control and SSP2-4.5 treatments to only 11% for the SSP5-8.5 treatment. The death of embryos was preceded by distinct individual growth trajectories between the treatments, and also revealed inter-individual variations within treatments. Embryos with the lowest hatching success had lower yolk consumption rates, and growth rates associated with a lower energy assimilation, and almost all of them failed to transition to internal gills. Within 6 months after hatching, no additional mortality was observed due to cooler temperatures.

Shark critical life stage vulnerability to monthly temperature variations under climate change

Climate change is pushing temperatures towards intolerable limits for many fishes. It is therefore crucial that we understand the capacity of animals to withstand warming to inform conservation actions. Yet, we currently lack evidence of how intraspecific factors, such as body size or population, affect the capacity of individuals to tolerate warming. Using black bream (Acanthopagrus butcheri) as a focal species, we tested two hypotheses: first, that population-level differences exist in thermal tolerance, with northern populations being more tolerant of warming; and second, that upper thermal limits increase with increasing body size. Black bream grow upwards of 2 kg in size and form genetically distinct populations among estuaries along the West Australian coastline, offering a natural experiment of how intraspecific factors affect temperature tolerance. The first hypothesis was tested by measuring the critical thermal maximum (CTmax) of fish from four distinct populations along an eight-degree latitudinal gradient. The influence of body mass on CTmax was tested across a 6- to 8-fold body mass range. These data provide critical insight into the capacity of black bream to cope with environmental warming. We will highlight the importance of intraspecific factors when assessing a species' vulnerability to climate change.

Are all fish the same? Importance of considering how intraspecific factors shape thermal limits

The global application of Transeius montdorensis (Acari: Phytoseiidae) mites as biological control agents across various protected crops has proven effective against small insects like thrips and whiteflies, as well as spider mites, broad mites, and russet mites. This research evaluated the development and reproduction of T. montdorensis when fed on diverse diets: cattail pollen (Typha latifolia L.), living dried fruit mite (Carpoglyphus lactis), frozen C. lactis eggs, and a combination of frozen C. lactis eggs and T. latifolia pollen. The results indicated that females consuming the mixture of frozen eggs of C. lactis and T. latifolia pollen exhibited superior total fecundity and daily oviposition rates. Moreover, the intrinsic rate of increase (rm) and net productive rate (R0) of T. montdorensis females fed on the mixed diet were highest among all diets tested. In contrast, the immature period was significantly longer for mites on a diet of living C. lactis compared to those on three other alternative diets. Importantly, utilizing frozen C. lactis eggs (and T. latifolia pollen) mitigates the risk of infestation and contamination from the dried fruit mites which is important for laboratories and field settings when releasing the predator colonies. Consequently, we present a safer strategy for multiplying T. montdorensis in laboratory conditions. Finally, our findings suggest that the application of frozen C. lactis eggs and T. latifolia pollen, potentially applicable to other predatory mite species, offers significant time and cost savings for scientists and companies.

Optimization of rearing Transeius montdorensis in laboratory conditions

Carnivorous plants have fascinated researchers for their unique adaptations to nutrient-poor environments, particularly their ability to capture and digest prey. However, it is still unclear whether pollutants accumulated in prey can be transferred to carnivorous plants. Black soldier flies (Hermetia illucens) have garnered attention for their remarkable potential in various environmental applications, including waste management and nutrient recycling. Furthermore, their capacity to bioaccumulate contaminants presents an intriguing avenue for bioremediation research.
We aim to explore the extent to which black soldier fly larvae take up cadmium and PFAS (Per- and Polyfluoroalkyl Substances) from the substrate, how these contaminants are passed along the different life stages of the insect, and finally to what extent carnivorous plants (Venus Fly Traps; Dionaea muscipula) accumulate these substances after consuming contaminated prey.
The study consists of a series of controlled exposure experiments where Venus flytraps are exposed to PFAS or cadmium through: 1) soil, 2) larvae and flies exposed to polluted substrate during their larval stages, or 3) the combination of both. After solvent extraction and solid phase extraction, Cadmium and PFAS in the organisms is quantified using ICP-MS and UPLC-MS/MS respectively.
Results from this study, for the first time, will reveal bioaccumulation patterns of cadmium and PFAS in larvae and highlight potential trophic transfer of pollutants in Venus fly traps.
Overall, this research will help to understand pollutant transfer dynamics and to develop innovative bioremediation approaches that harness the natural capabilities of carnivorous plants and Black soldier flies.

Tracing the contamination's footprint: does cadmium and PFAS accumulate in Venus Fly trap when fed with contaminated Black Soldier Flies?

Estuaries face heightened vulnerability due to global changes, including frequent intensified flooding from high-intensity rainfall events, which induce sudden changes in environmental parameters. While estuarine organisms thrive in fluctuating conditions, their responses to intense and prolonged stressors may vary. Furthermore, the combined effects of stressors (e.g., decreased salinity and pH, increased turbidity) encountered during floods have rarely been studied on invertebrates under controlled conditions. Consequently, we evaluated the sensitivity of three dominant mollusk species (Littorina saxatilis, Macoma balthica, Mytilus spp.) to spring floods conditions. During 5 weeks, we exposed specimens to a 12-level gradient of exposure to periodic freshwater injections ranging from 0 to 9 days, under both control (salinity 0, pH 8.1, suspended sediment 0 mg L-1) and spring flood conditions (salinity 0, pH 5.7, suspended sediment 325 mg L-1). Mortality, growth and shell wear were measured after 2.5 and 5 weeks. For each species and sampling period, we used mixed linear models with two fixed factors: treatment (two levels, "control" or "spring floods") and hypoosmotic stress period (12 levels). Breakpoint analyses were used to identify sudden changes in each significant regression. Spring flood conditions amplified the negative impact of freshwater exposure on the mortality and induced greater shell wear of all species. Additionally, species-specific vulnerability levels were detected. Extreme events could therefore be key factors determining species distribution and functioning of estuarine ecosystems. Our study underscores the need to consider ecologically relevant combinations of environmental factors representing the complexity of natural conditions.

Surviving the deluge: Examining the vulnerability of an estuarine mollusk assemblage to water changes associated to flooding conditions

During heat exposure, birds face a trade-off between
hyperthermia and dehydration. Numerous studies have
attempted to predict cooling costs for birds, which are expected
to increase with global warming. Although modelling dehydration
risk is important, it does have its limitations, and do not replace
direct measurement of hydration status. In fact, studies
assessing the effects of temperature on the hydration status of
wild birds are surprisingly rare. In this article, we discuss the
experimental evidence for the hyperthermia–dehydration
tradeoff, and the limitations of modelling avian dehydration risk
through set thermal limits. In addition, we present a systematic review of physiological
markers of dehydration for avian species. We find that plasma
osmolarity and plasma concentrations of sodium and chloride
are the most reliable markers of dehydration, and seem to scale
with dehydration severity. Hematocrit appears to predict
dehydration but multiple concerns impede its suitability. Plasma
concentrations of uric acid, urea and creatinine may represent
adequate markers of dehydration. Alternatively, characteristics
of the excreta may represent less-invasive means to assess
hydration status.

Physiological markers of avian dehydration and perspectives in ecophysiology: assessing the hyperthermia-dehydration tradeoff

Changed seasonality and increasing temperatures are hallmarks of the ongoing climate change and challenge the viability of individuals, populations, species, and ecosystems. Recent research suggests that aquatic ectotherms such as fish, especially early life-stages are vulnerable to increasing temperatures. To understand, predict, and possibly mitigate the consequences of climate change, it is thus crucial to investigate the causes of variation in early life-stage thermal performance of ectotherms. Egg size has received considerable attention in this context, but previous studies have been limited to species and population comparisons, neglecting the role of egg size variation structuring variation in thermal performance among individuals within populations. This constrains our mechanistic understanding of egg size as a modulator of thermal performance and how organisms may respond to climate change. To test how intraspecific variation in egg size influences thermal performance, we conducted a split-brood experiment where eggs from 64 female pike (Esox lucius) from the same population were fertilized and incubated at four temperatures until hatching. Results showed that larger eggs had higher hatching performance in low temperatures whereas smaller eggs were more successful in higher temperatures. This suggests that fitness advantages associated with larger eggs may change in the future climate.

Smaller pike eggs outperform bigger eggs in a global warming scenario

Wild organisms are usually infected with a whole range of parasites, however, the infection status of organisms is not usually taken into consideration in ecological and food web studies. The impact that parasites can have on their host organisms, affecting their food intake and internal resource use, might drive to differences in the isotopic composition or niche between infected and uninfected organisms, and thus to erroneous conclusions in stable isotope ecology studies. 
This is the first time that controlled diet-switch experiments and stable isotope analyses (whole tissue, bulk SIA, 13C and 15N) have been performed on a host-parasite system comparing infected and uninfected individuals. Our results highlight the importance of accounting for infection status when conducting ecological studies based on stable isotopes, also contributing to fill the gap of parasite contribution to food webs. 


Importance of accounting for the infection status of an organism in isotope ecology studies: Using feeding experiments as an example

Exploration provides information of the environment and its associated points of interest such as food, threats or mates. However, in experimental biology, exploration is vastly described as distance or area covered by the animals (typically rodents). Usually, experimental tests commonly used in laboratories tend to prioritise the minimisation of variables over the complexity of natural environments. While these setups have provided valuable insights, the technological advent of new analysis and 3D printing technologies, allows us to go beyond overly simplistic environments, in order to better understand animal behaviour in contexts that more closely mimic their natural habitats.
We designed an Enriched Open Field (EOF) by including modular plastic structures in a classic squared open field (OF) arena for mice in order to increase the number of environmentally relevant landmarks in the arena, so as the quantity of regions with exploratory salience. We tested CD-1 and C57/BL6 female mice roaming freely in the EOF and OF arenas for 10 minutes. 
As expected, we observed differences between strains, with greater exploration measures in the CD-1 strain. Animals tested in the EOF showed more consistent exploratory patterns, even if they were previously habituated to the modular pieces in the context of a home cage. The average speed of EOF tested animals was greater and the movement more continuous.
Our study suggests that the presence of structures may mimic more naturalistic environments, thereby promoting exploratory behaviours that are closer to those exhibited in the animals' natural habitat when foraging or looking for social cues. 


Towards a more naturalistic perspective: Enriched open field as an ethologically-relevant exploratory paradigm

The depletion of dissolved oxygen (DO) in global oceans is a growing concern. This phenomenon is observed in coastal and oceanic waters, where different mechanisms contribute. In the Estuary and Gulf of Saint Lawrence (SL), this process of deoxygenation has been documented and is mainly attributed to a greater inflow of the warm, DO-poor North American Central Waters deeper in the water column, isolated by a persistent pycnocline. The responses of organisms chronically under these conditions, particularly benthic invertebrates with low to no mobility, usually encompass molecular modifications (thus complex physiological changes), to cope with environmental hypoxia. Such changes might also be reflected on the proteome, given the range of functions of these molecules on cell structure and metabolism. However, the characterisation of complex proteomic responses in situ is not yet fully addressed. Therefore, the aim of this work is to describe and compare the proteomic profile of a benthic invertebrate across the natural deoxygenation gradient of the SL. We sampled individuals of the annelid Neloeanira tetragona from four subregions across the gradient of the SL and on a well oxygenated outgroup region, the Saguenay Fjord. Proteins were identified and quantified by high resolution LC-MS/MS on whole body samples. The profiles obtained were tested both via pairwise comparisons and multivariate modelling using environmental data. These analyses ultimately highlighted site-specific responses, particularly linked to DO levels, with an overrepresentation of energy metabolism, cell signalling and protein homeostasis pathways. N. tetragona exhibits a compensatory accumulation strategy to cope with environmental chronic hypoxia.

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