Canada

Directly predicting human epidermal growth factor receptor 2 (HER2) status from widely available hematoxylin and eosin (HE)-stained whole slide images (WSIs) can reduce technical costs and expedite treatment selection. Accurately predicting HER2 requires large collections of multi-site WSIs. Federated learning enables collaborative training of these WSIs without gigabyte-size WSIs transportation and data privacy concerns. However, federated learning encounters challenges in addressing label imbalance in multi-site WSIs from the real world. Moreover, existing WSI classification methods cannot simultaneously exploit local context information and long-range dependencies in the site-end feature representation of federated learning. To address these issues, we present a point transformer with federated learning for multi-site HER2 status prediction from HE-stained WSIs. Our approach incorporates two novel designs. We propose a dynamic label distribution strategy and an auxiliary classifier, which helps to establish a well-initialized model and mitigate label distribution variations across sites. Additionally, we propose a farthest cosine sampling based on cosine distance. It can sample the most distinctive features and capture the long-range dependencies. Extensive experiments and analysis show that our method achieves state-of-the-art performance at four sites with a total of 2687 WSIs. Furthermore, we demonstrate that our model can generalize to two unseen sites with 229 WSIs. Code is available at: https://github.com/boyden/PointTransformerFL

AAAI 2024

Point Transformer with Federated Learning for Predicting Breast Cancer HER2 Status from Hematoxylin and Eosin-Stained Whole Slide Images

whole slide image

medical and biological imaging

computational pathology

The purpose of the AAAI conference is to promote research in artificial intelligence (AI) and scientific exchange among AI researchers, practitioners, scientists, and engineers in affiliated disciplines. 

AAAI 2022

technical paper

We are pleased to announce the Thirty-Eighth AAAI Conference on Artificial Intelligence (AAAI-24), which will be held in Vancouver, British Columbia at the Vancouver Convention Centre – West Building from 20-27 February, 2024.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-24 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

We expect for AAAI-24 to be an in-person conference – one author of all accepted papers will be expected to present work in person unless there are exceptional circumstances that prevent this.<br><br><br><br>

In order to access the AAAI-24 event page you need to register [here](https://aaai.org/aaai-conference/registration/)

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. 

Class-incremental object detection (CIOD) is a real-world desired capability, requiring an object detector to continuously adapt to new tasks without forgetting learned ones, with the main challenge being catastrophic forgetting. Many methods based on distillation and replay have been proposed to alleviate this problem. However, they typically learn on a pure visual backbone, neglecting the powerful representation capabilities of textual cues, which to some extent limits their performance. In this paper, we propose task-aware language-image representation to mitigate catastrophic forgetting, introducing a new paradigm for language-image-based CIOD. First of all, we demonstrate the significant advantage of language-image detectors in mitigating catastrophic forgetting. Secondly, we propose a learning task-aware language-image representation method that overcomes the existing drawback of directly utilizing the language-image detector for CIOD. More specifically, we learn the language-image representation of different tasks through an insulating approach in the training stage, while using the alignment scores produced by task-specific language-image representation in the inference stage. Through our proposed method, language-image detectors can be more practical for CIOD. We conduct extensive experiments on COCO 2017 and Pascal VOC 2007 and demonstrate that the proposed method achieves state-of-the-art results under the various CIOD settings.

Learning Task-Aware Language-Image Representation for Class-Incremental Object Detection

Efficient computation or approximation of Levenshtein distance, a widely-used metric for evaluating sequence similarity, has attracted significant attention with the emergence of DNA storage and other biological applications. Sequence embedding, which maps Levenshtein distance to a conventional distance between embedding vectors, has emerged as a promising solution. In this paper, a novel neural network-based sequence embedding technique using Poisson regression is proposed. We first provide a theoretical analysis of the impact of embedding dimension on model performance and present a criterion for selecting an appropriate embedding dimension. Under this embedding dimension, the Poisson regression is introduced by assuming the Levenshtein distance between sequences of fixed length following a Poisson distribution, which naturally aligns with the definition of Levenshtein distance. Moreover, from the perspective of the distribution of embedding distances, Poisson regression approximates the negative log likelihood of the chi-squared distribution and offers advancements in removing the skewness. Through comprehensive experiments on real DNA storage data, we demonstrate the superior performance of the proposed method compared to state-of-the-art approaches.

Levenshtein Distance Embedding with Poisson Regression for DNA Storage

In recent years, the task of learned point cloud compression has gained prominence. An important type of point cloud, LiDAR point cloud, is generated by spinning LiDAR on vehicles. This process results in numerous circular shapes and azimuthal angle invariance features within the point clouds. However, these two features have been largely overlooked by previous methodologies. In this paper, we introduce a model-agnostic method called Spherical-Coordinate-based learned Point cloud compression (SCP), designed to fully leverage the features of circular shapes and azimuthal angle invariance. Additionally, we propose a multi-level Octree for SCP to mitigate the reconstruction error for distant areas within the Spherical-coordinate-based Octree. SCP exhibits excellent universality, making it applicable to various learned point cloud compression techniques. Experimental results demonstrate that SCP surpasses previous state-of-the-art methods by up to 29.14% in point-to-point PSNR BD-Rate.

SCP: Spherical-Coordinate-Based Learned Point Cloud Compression

Performing person detection in super-high-resolution images has been a challenging task. For such a task, modern detectors, which usually encode a box using center and width/height, struggle with accuracy due to two factors: 1) Human characteristic: people come in various postures and the center with high freedom is difficult to capture robust visual pattern; 2) Image characteristic: due to vast scale diversity of input (gigapixel-level), distance regression (for width and height) is hard to pinpoint, especially for a person, with substantial scale, who is near the camera. To address these challenges, we propose GigaHumanDet, an innovative solution aimed at further enhancing detection accuracy for gigapixel-level images. GigaHumanDet employs the corner modeling method to avoid the potential issues of a high degree of freedom in center pinpointing. To better distinguish similar-looking persons and enforce instance consistency of corner pairs, an instance-guided learning approach is designed to capture discriminative individual semantics. Further, we devise reliable shape-aware bodyness equipped with a multi-precision strategy as the human corner matching guidance to be appropriately adapted to the single-view large scene. Experimental results on PANDA and STCrowd datasets show the superiority and strong applicability of our design. Notably, our model achieves 82.4% in term of AP, outperforming current state-of-the-arts by more than 10%.

GigaHumanDet: Exploring Full-Body Detection on Gigapixel-Level Images

Recent advances in deep learning have greatly improved the segmentation of mitochondria from Electron Microscopy (EM) images. However, suffering from variations in mitochondrial morphology, imaging conditions, and image noise, existing methods still exhibit high uncertainty in their predictions. Moreover, in view of our findings, predictions with high levels of uncertainty are often accompanied by inaccuracies such as ambiguous boundaries and amount of false positive segments. To deal with the above problems, we propose a novel approach for mitochondria segmentation in 3D EM images that leverages evidential uncertainty estimation, which for the first time integrates evidential uncertainty to enhance the performance of segmentation. To be more specific, our proposed method not only provides accurate segmentation results, but also estimates associated uncertainty. Then, the estimated uncertainty is used to help improve the segmentation performance by an uncertainty rectification module, which leverages uncertainty maps and multi-scale information to refine the segmentation. Extensive experiments conducted on four challenging benchmarks demonstrate the superiority of our proposed method over existing approaches.

Evidential Uncertainty-Guided Mitochondria Segmentation for 3D EM Images

Talking upper-body synthesis is a promising task due to its versatile potential for video creation and consists of animating the body and face from a source image with the motion from a given driving video. However, prior synthesis approaches fall short in addressing this task and have been either limited to animating heads of a target person only, or have animated the upper body but neglected the synthesis of precise facial details. To tackle this task, we propose a Photo-realistic Talking Upper-body Synthesis method via 3D-aware motion decomposition warping, named PTUS, to both precisely synthesize the upper body as well as recover the details of the face such as blinking and lip synchronization. In particular, the motion decomposition mechanism consists of a face-body motion decomposition, which decouples the 3D motion estimation of the face and body, and a local-global motion decomposition, which decomposes the 3D face motion into global and local motions resulting in the transfer of facial expression. The 3D-aware warping module transfers the large-scale and subtle 3D motions to the extracted 3D depth-aware features in a coarse-tofine manner. Moreover, we present a new dataset, Talking-UB, which includes upper-body images with high-resolution faces, addressing the limitations of prior datasets that either consist of only facial images or upper-body images with blurry faces. Experimental results demonstrate that our proposed method can synthesize high-quality videos that preserve facial details, and achieves superior results compared to state-of-the-art cross-person motion transfer approaches.

PTUS: Photo-Realistic Talking Upper-Body Synthesis via 3D-Aware Motion Decomposition Warping

Among various interactions between humans, such as eye contact and gestures, physical interactions by contact can act as an essential moment in understanding human behaviors. Inspired by this fact, given a 3D partner human with the desired interaction label, we introduce a new task of 3D human generation in terms of physical contact. Unlike previous works of interacting with static objects or scenes, a given partner human can have diverse poses and different contact regions according to the type of interaction. To handle this challenge, we propose a novel method of generating interactive 3D humans for a given partner human based on a guided diffusion framework (ContactGen in short). Specifically, we newly present a contact prediction module that adaptively estimates potential contact regions between two input humans according to the interaction label. Using the estimated potential contact regions as complementary guidances, we dynamically enforce ContactGen to generate interactive 3D humans for a given partner human within a guided diffusion model. We demonstrate ContactGen on the CHI3D dataset, where our method generates physically plausible and diverse poses compared to comparison methods.

ContactGen: Contact-Guided Interactive 3D Human Generation for Partners

When dealing with tabular data, models based on decision
trees are a popular choice due to their high accuracy on these
data types, their ease of application, and explainability properties. However, when it comes to graph-structured data, it
is not clear how to apply them effectively, in a way that in-
corporates the topological information with the tabular data
available on the vertices of the graph. To address this challenge,
we introduce TREE-G. TREE-G modifies standard decision
trees, by introducing a novel split function that is specialized
for graph data. Not only does this split function incorporate
the node features and the topological information, but it also
uses a novel pointer mechanism that allows split nodes to
use information computed in previous splits. Therefore, the
split function adapts to the predictive task and the graph at
hand. We analyze the theoretical properties of TREE-G and
demonstrate its benefits empirically on multiple graph and
vertex prediction benchmarks. In these experiments, TREE-G
consistently outperforms other tree-based models and often
outperforms other graph-learning algorithms such as Graph
Neural Networks (GNNs) and Graph Kernels, sometimes by
large margins. Moreover, TREE-Gs models and their predic
tions can be explained and visualized.

TREE-G: Decision Trees Contesting Graph Neural Networks

Compound-Protein Interaction (CPI) prediction aims to predict the pattern and strength of compound-protein interactions for rational drug discovery. Existing deep learning-based methods utilize only the single modality of protein sequences or structures and lack the co-modeling of the joint distribution of the two modalities, which may lead to significant performance drops in complex real-world scenarios due to various factors, e.g., modality missing and domain shifting. More importantly, these methods only model protein sequences and structures at a single fixed scale, neglecting more fine-grained multi-scale information, such as those embedded in key protein fragments. In this paper, we propose a novel multi-scale Protein Sequence-structure Contrasting framework for CPI prediction (PSC-CPI), which captures the dependencies between protein sequences and structures through both intra-modality and cross-modality contrasting. We further apply length-variable protein augmentation to allow contrasting to be performed at different scales, from the amino acid level to the sequence level. Finally, in order to more fairly evaluate the model generalizability, we split the test data into four settings based on whether compounds and proteins have been observed during the training stage. Extensive experiments have shown that PSC-CPI generalizes well in all four settings, particularly in the more challenging ``Unseen-Both" setting, where neither compounds nor proteins have been observed during training. Furthermore, even when encountering a situation of modality missing, i.e., inference with only single-modality protein data, PSC-CPI still exhibits comparable or even better performance than previous approaches.

PSC-CPI: Multi-Scale Protein Sequence-Structure Contrasting for Efficient and Generalizable Compound-Protein Interaction Prediction

Call-and-response is a musical technique that enriches the creativity of music, crafting coherent musical ideas that mirror the back-and-forth nature of human dialogue with distinct musical characteristics. Although this technique is integral to numerous musical compositions, it remains largely uncharted in automatic music composition. To enhance the creativity of machine-composed music, we first introduce the Call-Response Dataset (CRD) containing 19,155 annotated musical pairs and crafted comprehensive objective evaluation metrics for musical assessment. Then, we design a knowledge-enhanced learning-based method to bridge the gap between human and machine creativity. Specifically, we train the composition module using the call-response pairs, supplementing it with musical knowledge in terms of rhythm, melody, and harmony. Our experimental results underscore that our proposed model adeptly produces a wide variety of creative responses for various musical calls.

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