Canada

Motivation: Advances in single-cell measurement techniques provide rich multimodal data, which helps us to explore the life state of cells more deeply. However, multimodal integration, or, learning joint embeddings from multimodal data remains a current challenge. The difficulty in integrating unpaired single-cell multimodal data is that different modalities have different feature spaces, which easily leads to information loss in joint embedding. And few existing methods have fully exploited and fused the information in single-cell multimodal data. Result: In this study, we propose CoVEL, a deep learning method for unsupervised integration of single-cell multimodal data. CoVEL learns single-cell representations from a comprehensive view, including regulatory relationships between modalities, fine-grained representations of cells, and relationships between different cells. The comprehensive view embedding enables CoVEL to remove the gap between modalities while protecting biological heterogeneity. Experimental results on multiple public datasets show that CoVEL is accurate and robust to single-cell multimodal integration. Data availability: https://github.com/shapsider/scintegration.

AAAI 2024

Comprehensive View Embedding Learning for Single-Cell Multimodal Integration

app: other applications

app: natural sciences

ml: applications

### WELCOME!

We’re connecting the scientific community and bringing the ultimate virtual summit to you. Learn about the latest trends in immunology from today’s influencers. Discover how they leverage high-dimensional biology to drive new discoveries and research. Earn CE credit. All from your browser. All at no cost to you.
 

### Gain insights from the following influencers in immunology: ###

Registration for this event is free. Please click on the button below to register.

Free registration

Insights Immunology 2021

We’re connecting the scientific community and bringing the ultimate virtual summit to you. Learn about the latest trends in immunology from today’s influencers. Discover how they leverage high-dimensional biology to drive new discoveries and research. Earn CE credit. All from your browser. All at no cost to you.

2021 Insights Immunology event page: https://underline.io/events/173/reception


technical paper

We are pleased to announce the Thirty-Eighth AAAI Conference on Artificial Intelligence (AAAI-24), which will be held in Vancouver, British Columbia at the Vancouver Convention Centre – West Building from 20-27 February, 2024.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-24 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

We expect for AAAI-24 to be an in-person conference – one author of all accepted papers will be expected to present work in person unless there are exceptional circumstances that prevent this.

In order to access the AAAI-24 event page you need to register [here](https://aaai.org/aaai-conference/registration/)

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. 

Lidar-based 3D Detection is one of the significant components of Autonomous Driving. However, current methods over-focus on improving the performance of 3D Lidar perception, which causes the architecture of networks becoming complicated and hard to deploy. Thus, the methods are difficult to apply in Autonomous Driving for real-time processing. In this paper, we propose a high-efficiency network, SwiftPillars, which includes Swift Pillar Encoder  (SPE) and Multi-scale Aggregation Decoder  (MAD). The SPE is constructed by a concise Dual-attention Module with lightweight operators. The Dual-attention Module utilizes feature pooling, matrix multiplication, etc. to speed up point-wise and channel-wise attention extraction and fusion. The MAD interconnects multiple scale features extracted by SPE with minimal computational cost to leverage performance. In our experiments, our proposal accomplishes 61.3% NDS and 53.2% mAP in nuScenes dataset. In addition, we evaluate inference time on several platforms  (P4,  T4,  A2, MLU370, RTX3080), where SwiftPillars achieves up to 13.3ms  (75FPS) on NVIDIA Tesla T4. Compared with PointPillars, SwiftPillars is on average 24.34% faster in inference speed with equivalent GPUs and a higher mAP of approximately 3.2%  in the nuScenes dataset.

SwiftPillars: High-Efficiency Pillar Encoder for Lidar-Based 3D Detection

The emergence of ChatGPT has once again sparked research in generative artificial intelligence (GAI). While people have been amazed by the generated results, they have also noticed the reasoning potential reflected in the generated textual content. However, this current ability for causal reasoning is primarily limited to the domain of language generation, such as in models like GPT-3. In visual modality, there is currently no equivalent research. Considering causal reasoning in visual content generation is significant. This is because visual information contains infinite granularity. Particularly, images can provide more intuitive and specific demonstrations for certain reasoning tasks, especially when compared to coarse-grained text. Hence, we propose a new image generation task called visual question answering with image (VQAI) and establish a dataset of the same name based on the classic Tom and Jerry animated series. Additionally, we develop a new paradigm for image generation to tackle the challenges of this task. Finally, we perform extensive experiments and analyses, including visualizations of the generated content and discussions on the potentials and limitations. The code and data are publicly available under the license of CC BY-NC-SA 4.0 for academic and non-commercial usage.

Image Content Generation with Causal Reasoning | VIDEO

While text-3D editing has made significant strides in leveraging score distillation sampling, emerging approaches still fall short in delivering separable, precise and consistent outcomes that are vital to content creation. In response, we introduce FocalDreamer, a framework that merges base shape with editable parts according to text prompts for fine-grained editing within desired regions. Specifically, equipped with geometry union and dual-path rendering, FocalDreamer assembles independent 3D parts into a complete object, tailored for convenient instance reuse and part-wise control. We propose geometric focal loss and style consistency regularization, which encourage focal fusion and congruent overall appearance. Furthermore, FocalDreamer generates high-fidelity geometry and PBR textures which are compatible with widely-used graphics engines. Extensive experiments have highlighted the superior editing capabilities of FocalDreamer in both quantitative and qualitative evaluations.

FocalDreamer: Text-Driven 3D Editing via Focal-Fusion Assembly

RAW to sRGB mapping, which aims to convert RAW images from smartphones into RGB form equivalent to that of Digital Single-Lens Reflex (DSLR) cameras, has become an important area of research. However, current methods often ignore the difference between cell phone RAW images and DSLR camera RGB images, a difference that goes beyond the color matrix and extends to spatial structure due to resolution variations. Recent methods directly rebuild color mapping and spatial structure via shared deep representation, limiting optimal performance. Inspired by Image Signal Processing (ISP) pipeline, which distinguishes image restoration and enhancement, we present a novel Neural ISP framework, named FourierISP. This approach breaks the image down into style and structure within the frequency domain, allowing for independent optimization. FourierISP is comprised of three subnetworks: Phase Enhance Subnet for structural refinement, Amplitude Refine Subnet for color learning, and Color Adaptation Subnet for blending them in a smooth manner. This approach sharpens both color and structure, and extensive evaluations across varied datasets confirm that our approach realizes state-of-the-art results. Code will be available at https://github.com/alexhe101/FourierISP.

Enhancing RAW-to-sRGB with Decoupled Style Structure in Fourier Domain | VIDEO

Open-sourced large language models (LLMs) have demonstrated remarkable efficacy in various tasks with instruction tuning. 
However, these models can sometimes struggle with tasks that require more specialized knowledge such as translation. 
One possible reason for such deficiency is that instruction tuning aims to generate fluent and coherent text that continues from a given instruction without being constrained by any task-specific requirements. 
Moreover, it can be more challenging to tune smaller LLMs with lower-quality training data.
To address this issue, we propose a novel framework using examples in comparison to teach LLMs to learn translation. 
Our approach involves output comparison and preference comparison, presenting the model with 
carefully designed examples of correct and incorrect translations and an additional preference loss for better regularization.
Empirical evaluation on four language directions of WMT2022 and FLORES-200 benchmarks shows the superiority of our proposed method over existing methods. 
Our findings offer a new perspective on fine-tuning LLMs for translation tasks and provide a promising solution for generating high-quality translations.
Please refer to Github for more details:
https://github.com/lemon0830/TIM.

Teaching Large Language Models to Translate with Comparison

Multi-Task Learning (MTL) is designed to train multiple correlated tasks simultaneously, thereby enhancing the performance of individual tasks. Typically, a multi-task network structure consists of a shared backbone and task-specific decoders. However, the complexity of the decoders increases with the number of tasks. To tackle this challenge, we integrate the decoder-free vision-language model CLIP, which exhibits robust zero-shot generalization capability. Recently, parameter-efficient transfer learning methods have been extensively explored with CLIP for adapting to downstream tasks, where prompt tuning showcases strong potential. Nevertheless, these methods solely fine-tune a single modality (text or visual), disrupting the modality structure of CLIP. In this paper, we first propose Multi-modal Alignment Prompt (MmAP) for CLIP, which aligns text and visual modalities during fine-tuning process. Building upon MmAP, we develop an innovative multi-task prompt learning framework. On the one hand, to maximize the complementarity of tasks with high similarity, we utilize a gradient-driven task grouping method that partitions tasks into several disjoint groups and assign a group-shared MmAP to each group. On the other hand, to preserve the unique characteristics of each task, we assign an task-specific MmAP to each task. Comprehensive experiments on two large multi-task learning datasets demonstrate that our method achieves significant performance improvements compared to full fine-tuning while only utilizing approximately ~ 0.09% of trainable parameters.

MmAP: Multi-Modal Alignment Prompt for Cross-Domain Multi-Task Learning

CEM-TD3 is a combination scheme using the simple cross-entropy method (CEM) and Twin Delayed Deep Deterministic policy gradient (TD3), and it achieves a satisfactory trade-off between performance and sample efficiency. However, we find that CEM-TD3 cannot fully address the low efficiency of policy search caused by CEM, and the policy gradient learning introduced by TD3 will weaken the diversity of individuals in the population. In this paper, we propose Double Buffers CEM-TD3 (DBCEM-TD3) that optimizes both CEM and TD3. For CEM, DBCEM-TD3 maintains an actor buffer to store the population required for evolution. In each iteration, it only needs to generate a small number of actors to replace the poor actors in the policy buffer to achieve more efficient evolution. The fitness of individuals in the actor buffer decreases exponentially with time, which can avoid premature convergence of the mean actor. For TD3, DBCEM-TD3 maintains a critic buffer with the same number of critics as the number of actors generated in each iteration, and each critic is trained independently by sampling from the shared replay buffer. In each iteration, each newly generated actor uses different critics to guide learning. This ensures more diverse behaviors among the learned actors, enabling richer experiences to be collected during the evaluation phase. We conduct experimental evaluations on five continuous control tasks provided by OpenAI Gym. DBCEM-TD3 outperforms CEM-TD3, TD3, and other classic off-policy reinforcement learning algorithms in terms of performance and sample efficiency.

Double Buffers CEM-TD3: More Efficient Evolution and Richer Exploration

Exploration in decentralized cooperative multi-agent reinforcement learning faces two challenges. One is that the novelty of global states is unavailable, while the novelty of local observations is biased. The other is how agents can explore in a coordinated way. To address these challenges, we propose MACE, a simple yet effective multi-agent coordinated exploration method. By communicating only local novelty, agents can take into account other agents' local novelty to approximate the global novelty. Further, we newly introduce weighted mutual information to measure the influence of one agent's action on other agents' accumulated novelty. We convert it as an intrinsic reward in hindsight to encourage agents to exert more influence on other agents' exploration and boost coordinated exploration. Empirically, we show that MACE achieves superior performance in three multi-agent environments with sparse rewards.

Settling Decentralized Multi-Agent Coordinated Exploration by Novelty Sharing

Video class-incremental learning aims to recognize new actions while restricting the catastrophic forgetting of old ones, whose representative samples can only be saved in limited memory. Semantically variable subactions are susceptible to class confusion due to data imbalance. While existing methods address the problem by estimating and distilling the spatio-temporal knowledge, we further explores that the refinement of hierarchical correlations is crucial for the alignment of spatio-temporal features. To enhance the adaptability on evolved actions, we proposes a hierarchical aggregation strategy, in which  hierarchical matching matrices are combined and jointly optimized to selectively store and retrieve relevant features from previous tasks. Meanwhile, a correlation refinement mechanism is presented to reinforce the bias on informative exemplars according to online hypercorrelation distribution. Experimental results demonstrate the effectiveness of the proposed method on three standard video class-incremental learning benchmarks, outperforming state-of-the-art methods. Code is available at: https://github.com/Lsen991031/HCE

Hypercorrelation Evolution for Video Class-Incremental Learning

Diffusion-based Image Editing (DIE) is an emerging research hot-spot, which often applies a semantic mask to control the target area for diffusion editing. However, most existing solutions obtain these masks via manual operations or off-line processing, greatly reducing their efficiency. In this paper, we propose a novel and efficient image editing method for T2I diffusion models, termed Instant Diffusion Editing (InstDiffEdit). In particular, InstDiffEdit aims to employ the cross-modal attention ability of Text to Image (T2I) models to achieve instant mask guidance in diffusion steps. To reduce the noise of hidden attention maps and obtain the fully automatics, we equip InstDiffEdit with a training-free attention refinement scheme to adaptively aggregate the attention distributions for the automatic yet accurate mask generation. Meanwhile, to supplement the existing evaluations of DIE, we also propose a new benchmark called Editing-Mask for the evaluation of local editing ability. We also conduct extensive experiments on ImageNet and Imagen, and compare it with a bunch of the state-of-the-art (SOTA) methods. The experimental results show that InstDiffEdit not only outperforms the SOTA methods in both image quality and manipulation results, but also achieves obvious improvement in inference speed, i.e., up to 5 to 6 times. Our code is available at https://anonymous.4open.science/r/InstDiffEdit-C306/

Downloads

Next from AAAI 2024

SwiftPillars: High-Efficiency Pillar Encoder for Lidar-Based 3D Detection

Similar lecture

Leveraging the power of high-parameter cell sorting and single-cell multiomics to profile intratumoral immune cells in a modal of B-cell lymphoma