United States

Survival prediction based on whole slide images (WSIs) is a challenging task for patient-level multiple instance learning (MIL). Due to the vast amount of data for a patient (one or multiple gigapixels WSIs) and the irregularly shaped property of WSI, it is difficult to fully explore spatial, contextual, and hierarchical interaction in the patient-level bag. Many studies adopt random sampling pre-processing strategy and WSI-level aggregation models, which inevitably lose critical prognostic information in the patient-level bag. In this work, we propose a hierarchical vision Transformer framework named HVTSurv, which can encode the local-level relative spatial information, strengthen WSI-level context-aware communication, and establish patient-level hierarchical interaction. Firstly, we design a feature pre-processing strategy, including feature rearrangement and random window masking. Then, we devise three layers to progressively obtain patient-level representation, including a local-level interaction layer adopting Manhattan distance, a WSI-level interaction layer employing spatial shuffle, and a patient-level interaction layer using attention pooling. Moreover, the design of hierarchical network helps the model become more computationally efficient. Finally, we validate HVTSurv with 3,104 patients and 3,752 WSIs across 6 cancer types from The Cancer Genome Atlas (TCGA). The average C-Index is  2.50-11.30% higher than all the prior weakly supervised methods over 6 TCGA datasets. Ablation study and attention visualization further verify the superiority of the proposed HVTSurv. Implementation is available at: https://github.com/szc19990412/HVTSurv.

AAAI 2023

HVTSurv: Hierarchical Vision Transformer for Patient-level Survival Prediction from Whole Slide Image

medical image analysis; whole slide image; survival prediction; transformer

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-23 is the Thirty-Seventh AAAI Conference on Artificial Intelligence. The theme of this conference is to create collaborative bridges within and beyond AI. Like previous AAAI conferences, AAAI-23 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and two new activities: a Bridge Program and a Lab Program. Many of these activities are tailored to the theme of bridges and all are selected according to the highest standards, with additional programs for students and young researchers. 
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The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines.

poster

Most Graph Neural Networks follow the message-passing paradigm, assuming the observed structure depicts the ground-truth node relationships. However, this fundamental assumption cannot always be satisfied, as real-world graphs are always incomplete, noisy, or redundant. How to reveal the inherent graph structure in a unified way remains under-explored. 
We proposed PRI-GSL, a Graph Structure Learning framework guided by the Principle of Relevant Information, providing a simple and unified framework for identifying the self-organization and revealing the hidden structure. PRI-GSL learns a structure that contains the most relevant yet least redundant information quantified by von Neumann entropy and Quantum Jensen Shannon divergence. PRI-GSL incorporates the evolution of quantum continuous walk with graph wavelets to encode node structural roles, showing in which way the nodes interplay and self-organize with the graph structure. Extensive experiments demonstrate the superior effectiveness and robustness of PRI-GSL. 

Self-organization Preserved Graph Structure Learning with Principle of Relevant Information

The recurrent structure is a prevalent framework for the task of video super-resolution, which models the temporal dependency between frames via hidden states. When applied to real-world scenarios with unknown and complex degradations, hidden states tend to contain unpleasant artifacts and propagate them to restored frames. In this circumstance, our analyses show that such artifacts can be largely alleviated when the hidden state is replaced with a cleaner counterpart. Based on the observations, we propose a Hidden State Attention (HSA) module to mitigate artifacts in real-world video super-resolution. Specifically, we first adopt various cheap filters to produce a hidden state pool. For example, Gaussian blur filters are for smoothing artifacts while sharpening filters are for enhancing details. To aggregate a new hidden state that contains fewer artifacts from the hidden state pool, we devise a Selective Cross Attention (SCA) module, in which the attention between input features and each hidden state is calculated. Equipped with HSA, our proposed method, namely FastRealVSR, is able to achieve 2x speedup while obtaining better performance than Real-BasicVSR. Codes will be available at https://github.com/TencentARC/FastRealVSR.

Mitigating Artifacts in Real-World Video Super-Resolution Models

Conditional text generation is to generate text sequences conditioning on linguistic or non-linguistic data. The main line of existing work proposed deterministic models to improve the fidelity of the generated text but often ignored the diversity. Another line relied on conditional variational auto-encoders (CVAEs), which increased the diversity over their deterministic backbones. However, CVAEs regard diversity as an implicit objective and may not be optimal. In this paper, we raise two questions: 1) Can diversity be further improved with an explicit objective? 2) Since fidelity and diversity are two conflicting objectives, how can we obtain different multi-objective optimal solutions according to user preferences? To answer question 1), we propose a multi-objective reinforcement learning (MORL) method which explicitly takes CIDEr and Self-CIDEr scores as the fidelity-oriented and diversity-oriented rewards respectively. To answer question 2), we propose a preference-controlled MORL method, which can obtain infinite multi-objective optimal solutions by tuning the preference variable. We conduct extensive experiments on paraphrasing and image captioning tasks, which show that our model outperforms both deterministic and CVAE-based baselines in the fidelity-diversity trade-off space.

Preference-Controlled Multi-Objective Reinforcement Learning for Conditional Text Generation

Pre-trained vision-language models like CLIP have recently shown superior performances on various downstream tasks, including image classification and segmentation. However, in fine-grained image re-identification (ReID), the labels are indexes, lacking concrete text descriptions. Therefore, it remains to be determined how such models could be applied to these tasks. This paper first finds out that simply fine-tuning the visual model initialized by the image encoder in CLIP, has already obtained competitive performances in various ReID tasks. Then we propose a two-stage strategy to facilitate a better visual representation. The key idea is to fully exploit the cross-modal description ability in CLIP through a set of learnable text tokens for each ID and give them to the text encoder to form ambiguous descriptions. In the first training stage, image and text encoders from CLIP keep fixed, and only the text tokens are optimized from scratch by the contrastive loss computed within a batch. In the second stage, the ID-specific text tokens and their encoder become static, providing constraints for fine-tuning the image encoder. With the help of the designed loss in the downstream task, the image encoder is able to represent data as vectors in the feature embedding accurately. The effectiveness of the proposed strategy is validated on several datasets for the person or vehicle ReID tasks. Code is available at https://github.com/Syliz517/CLIP-ReID.

CLIP-ReID: Exploiting Vision-Language Model for Image Re-Identification without Concrete Text Labels

Efficiently training accurate deep models for weakly supervised semantic segmentation (WSSS) with image-level labels is challenging and important. Recently, end-to-end WSSS methods have become the focus of research due to their high training efficiency. However, current methods suffer from insufficient extraction of comprehensive semantic information, resulting in low-quality pseudo-labels and sub-optimal solutions for end-to-end WSSS. To this end, we propose a simple and novel Self Correspondence Distillation (SCD) method to refine pseudo-labels without introducing external supervision. Our SCD enables the network to utilize feature correspondence derived from itself as a distillation target, which can enhance the network's feature learning process by complementing semantic information. In addition, to further improve the segmentation accuracy, we design a Variation-aware Refine Module to enhance the local consistency of pseudo-labels by computing pixel-level variation. Finally, we present an efficient end-to-end Transformer-based framework (TSCD) via SCD and Variation-aware Refine Module for the accurate WSSS task. Extensive experiments on the PASCAL VOC 2012 and MS COCO 2014 datasets demonstrate that our method significantly outperforms other state-of-the-art methods.  Our code is available at https://github.com/Rongtao-Xu/RepresentationLearning/tree/main/SCD-AAAI2023.

Self Correspondence Distillation For End-to-End Weakly-Supervised Semantic Segmentation

In the field of representation learning on knowledge graphs (KGs), a hyper-relational fact consists of a main triple and several auxiliary attribute-value descriptions, which is considered more comprehensive and specific than a triple-based fact. However, currently available hyper-relational KG embedding methods in a single view are limited in application because they weaken the hierarchical structure that represents the affiliation between entities. To overcome this limitation, we propose a dual-view hyper-relational KG structure (DH-KG) that contains a hyper-relational instance view for entities and a hyper-relational ontology view for concepts that are abstracted hierarchically from the entities. This paper defines link prediction and entity typing tasks on DH-KG for the first time and constructs two DH-KG datasets, JW44K-6K, extracted from Wikidata, and HTDM based on medical data. Furthermore, we propose DHGE, a DH-KG embedding model based on GRAN encoders, HGNNs, and joint learning. DHGE outperforms baseline models on DH-KG, according to experimental results. Finally, we provide an example of how this technology can be used to treat hypertension. Our model and new datasets are publicly available.

DHGE: Dual-view Hyper-Relational Knowledge Graph Embedding for Link Prediction and Entity Typing

Electrophysiological Source Imaging (ESI) refers to reconstructing the underlying brain source activation from non-invasive Electroencephalography (EEG) and Magnetoencephalography (MEG) measurements. Estimating the source locations and their extended area is fundamental in neuroscience and clinical applications. 
However, the estimation is challenging because of the ill-posedness property and low signal-to-noise (SNR) level in the EEG/MEG data. In this work, a combinatorial search framework is proposed to solve the ESI problem with a provable optimality guarantee by exploiting the graph neighborhood information in the brain source space. Specifically, we converted the ESI problem into a graph search problem and designed a combinatorial search algorithm under the framework of A* to solve it. The proposed algorithm is guaranteed to produce an optimal solution to the ESI problem.  Experimental results on both synthetic data and real epilepsy EEG data demonstrated that the proposed algorithm could faithfully reconstruct the electrical source activation in the brain.

Electrophysiological Brain Source Imaging via Combinatorial Search with Provable Optimality

The model identifiability is a considerable issue in the unsupervised learning of disentangled representations. The PCA inductive biases revealed recently for unsupervised disentangling in VAE-based models are shown to improve local alignment of latent dimensions with principal components of the data. In this paper, in additional to the PCA inductive biases, we propose novel geometric inductive biases from the manifold perspective for unsupervised disentangling, which induce the model to capture the global geometric properties of the data manifold with guaranteed model identifiability. We also propose a Geometric Disentangling Regularized AutoEncoder (GDRAE) that combines the PCA and the proposed geometric inductive biases in one unified framework. The experimental results show the usefulness of the geometric inductive biases in unsupervised disentangling and the effectiveness of our GDRAE in capturing the geometric inductive biases.

Geometric Inductive Biases for Identifiable Unsupervised Learning of Disentangled Representations

Self-supervised space-time correspondence learning is emerging as a promising way of leveraging unlabeled video. Currently, most methods adapt contrastive learning with mining negative samples or reconstruction adapted from the image domain, which requires dense affinity across multiple frames or optical flow constraints. Moreover, video correspondence predictive models require mining more inherent properties in videos, such as structural information. In this work, we propose the VideoHiGraph, a space-time correspondence framework based on a learnable graph kernel. Concerning the video as the spatial-temporal graph, the learning objectives of VideoHiGraph are emanated in a self-supervised manner for predicting unobserved hidden graphs via graph kernel manner. We learn a representation of the temporal coherence across frames in which pairwise similarity defines the structured hidden graph, such that a biased random walk graph kernel along the sub-graph can predict long-range correspondence. Then, we learn a refined representation across frames on the node-level via a dense graph kernel. The self-supervision of the model training is formed by the structural and temporal consistency of the graph. VideoHiGraph achieves superior performance and demonstrates its robustness across the benchmark of label propagation tasks involving objects, semantic parts, keypoints, and instances. Our algorithm implementations have been made publicly available at https://github.com/zyqin19/VideoHiGraph.

Exposing the Self-supervised Space-Time Correspondence Learning via Graph Kernels

Multi-person pose estimation (MPPE) has achieved impressive progress in recent years. However, due to the large variance of appearances among images or occlusions, the model can hardly learn consistent patterns enough, which leads to severe location jitter and missing issues. In this study, we propose a novel framework, termed \textbf{I}nter-image \textbf{Con}trastive consistency (ICON), to strengthen the keypoint consistency among images for MPPE. Concretely, we consider two-fold consistency constraints, which include single keypoint constrastive consistency (SKCC) and pair relation contrastive consistency (PRCC).  The SKCC learns to strengthen the consistency of individual keypoints across images in the same category to improve the category-specific robustness.
Only with SKCC, the model can effectively reduce location errors caused by large appearance variations, but remains challenging with extreme postures (e.g., occlusions) due to lack of relational guidance.  Therefore, PRCC is proposed to strengthen the consistency of pair-wise joint relation between images to preserve the instructive relation. Cooperating with SKCC, PRCC further improves structure aware robustness in handling extreme postures. Extensive experiments on kinds of architectures across three datasets (i.e., MS-COCO, MPII, CrowdPose) show the proposed ICON achieves substantial improvements over baselines. Furthermore, ICON under the semi-supervised setup can obtain comparable results with the fully-supervised methods using only 30% labeled data. 

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HVTSurv: Hierarchical Vision Transformer for Patient-level Survival Prediction from Whole Slide Image

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