United States

Drug dosing is an important application of AI, which can be formulated as a Reinforcement Learning (RL) problem. In this paper, we identify two major challenges of using RL for drug dosing: delayed and prolonged effects of administering medications, which break the Markov assumption of the RL framework. We focus on prolongedness and define PAE-POMDP (Prolonged Action Effect-Partially Observable Markov Decision Process), a subclass of POMDPs in which the Markov assumption does not hold specifically due to prolonged effects of actions. Motivated by the pharmacology literature, we propose a simple and effective approach to converting drug dosing PAE-POMDPs into MDPs, enabling the use of the existing RL algorithms to solve such problems. We validate the proposed approach on a toy task, and a challenging glucose control task, for which we devise a clinically-inspired reward function. Our results demonstrate that: (1) the proposed method to restore the Markov assumption leads to significant improvements over a vanilla baseline; (2) the approach is competitive with recurrent policies which may inherently capture the prolonged affect of actions; (3) it is remarkably more time and memory efficient than the recurrent baseline and hence more suitable for real-time dosing control systems; and (4) it exhibits favourable qualitative behavior in our policy analysis.

AAAI 2023

On the Challenges of using Reinforcement Learning in Precision Drug Dosing: Delay and Prolongedness of Action Effects

drug dosing

healthcare

reinforcement learning

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-23 is the Thirty-Seventh AAAI Conference on Artificial Intelligence. The theme of this conference is to create collaborative bridges within and beyond AI. Like previous AAAI conferences, AAAI-23 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and two new activities: a Bridge Program and a Lab Program. Many of these activities are tailored to the theme of bridges and all are selected according to the highest standards, with additional programs for students and young researchers. 
AAAI is providing you with a conference planner, which you can use to help organize your itinerary of activities. This includes talks to attend in person, talks to attend remotely, breaks with colleagues and your site seeing activities. To access this conference planner, please go to [https://aaai-2023.takemobi.io](https://aaai-2023.takemobi.io).

In order to access this site, you need to register. If you haven't already, please register [here](https://aaai.org/Conferences/AAAI-23/registration/).


The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines.

poster

The ability of snapshot compressive imaging (SCI) systems to efficiently capture high-dimensional (HD) data has led to an inverse problem, which consists of recovering the HD signal from the compressed and noisy measurement. While reconstruction algorithms grow fast to solve it with the recent advances of deep learning, the fundamental issue of accurate and stable recovery remains. To this end, we propose deep equilibrium models (DEQ) for video SCI, fusing data-driven regularization and stable convergence in a theoretically sound manner. Each equilibrium model implicitly learns a nonexpansive operator and analytically computes the fixed point, thus enabling unlimited iterative steps and infinite network depth with only a constant memory requirement in training and testing. Specifically, we demonstrate how DEQ can be applied to two existing models for video SCI reconstruction: recurrent neural networks (RNN) and Plug-and-Play (PnP) algorithms. On a variety of datasets and real data, both quantitative and qualitative evaluations of our results demonstrate the effectiveness and stability of our proposed method.

Deep Equilibrium Models for Snapshot Compressive Imaging

Depth images and point clouds are the two most commonly used data representations for depth-based 3D hand pose estimation. Benefiting from the structuring of image data and the inherent inductive biases of the 2D Convolutional Neural Network (CNN), image-based methods are highly efficient and effective. However, treating the depth data as a 2D image inevitably ignores the 3D nature of depth data. Point cloud-based methods can better mine the 3D geometric structure of depth data. However, these methods suffer from the disorder and non-structure of point cloud data, which is computationally inefficient. In this paper, we propose an Image-Point cloud Network (IPNet) for accurate and robust 3D hand pose estimation. IPNet utilizes 2D CNN to extract visual representations in 2D image space and performs iterative correction in 3D point cloud space to exploit the 3D geometry information of depth data. In particular, we propose a sparse anchor-based "aggregation-interaction-propagation'' paradigm to enhance point cloud features and refine the hand pose, which reduces irregular data access. Furthermore, we introduce a 3D hand model to the iterative correction process, which significantly improves the robustness of IPNet to occlusion and depth holes. Experiments show that IPNet outperforms state-of-the-art methods on three challenging hand datasets.

Two Heads are Better than One: Image-Point Cloud Network for Depth-Based 3D Hand Pose Estimation

Platforms for online civic participation rely heavily on methods for condensing thousands of comments into a relevant handful, based on whether participants agree or disagree with them. These methods should guarantee fair representation of the participants, as their outcomes may affect the health of the conversation and inform impactful downstream decisions. To that end, we draw on the literature on approval-based committee elections. Our setting is novel in that the approval votes are incomplete since participants will typically not vote on all comments. We prove that this complication renders non-adaptive algorithms impractical in terms of the amount of information they must gather. Therefore, we develop an adaptive algorithm that uses information more efficiently by presenting incoming participants with statements that appear promising based on votes by previous participants. We prove that this method satisfies commonly used notions of fair representation, even when participants only vote on a small fraction of comments. Finally, an empirical evaluation on real data shows that the proposed algorithm provides representative outcomes in practice.

Representation with Incomplete Votes

Visible-infrared person re-identification (VI-ReID) aims to retrieve the person images of the same identity from the RGB to infrared image space, which is very important for real-world surveillance system. In practice, VI-ReID is more challenging due to the heterogeneous modality discrepancy,
which further aggravates the challenges of traditional single-modality person ReID problem, i.e., inter-class confusion and intra-class variations.
In this paper, we propose an aggregated memory-based cross-modality deep metric learning framework, which benefits from the increasing number of learned modality-aware and modality-agnostic centroid proxies for cluster contrast and mutual information learning. Furthermore, to suppress the modality discrepancy, the proposed cross-modality alignment objective simultaneously utilizes both historical and up-to-date learned cluster proxies for enhanced cross-modality association. Such training mechanism helps to obtain hard positive references through increased diversity of learned cluster proxies, and finally achieves stronger ``pulling close'' effect between cross-modality image features. Extensive experiment results demonstrate the effectiveness of the proposed method, surpassing state-of-the-art works significantly by a large margin on the commonly used VI-ReID datasets. 

Cross-Modality Person Re-Identification with Memory-based Contrastive Embedding

The abundance of data has given machine learning considerable momentum in natural sciences and engineering, though modeling of physical processes is often difficult. A particularly tough problem is the efficient representation of geometric boundaries. Triangularized geometric boundaries are well understood and ubiquitous in engineering applications. However, it is notoriously difficult to integrate them into machine learning approaches due to their heterogeneity with respect to size and orientation. In this work, we introduce an effective theory to model particle-boundary interactions, which leads to our new Boundary Graph Neural Networks (BGNNs) that dynamically modify graph structures to obey boundary conditions. The new BGNNs are tested on complex 3D granular flow processes of hoppers, rotating drums and mixers, which are all standard components of modern industrial machinery but still have complicated geometry. BGNNs are evaluated in terms of computational efficiency as well as prediction accuracy of particle flows and mixing entropies. BGNNs are able to accurately reproduce 3D granular flows within simulation uncertainties over hundreds of thousands of simulation timesteps. Most notably, in our experiments, particles stay within the geometric objects without using handcrafted conditions or restrictions.

Boundary Graph Neural Networks for 3D Simulations

Participatory budgeting engages the public in the process of
allocating public money to different types of projects. PB designs
differ in how voters are asked to express their preferences
over candidate projects and how these preferences are
aggregated to determine which projects to fund. This paper
studies two fundamental questions in PB design. Which voting
format and aggregation method to use, and how to evaluate
the outcomes of these design decisions? We conduct an
extensive empirical study in which 1 800 participants vote in
four participatory budgeting elections in a controlled setting
to evaluate the practical effects of the choice of voting format
and aggregation rule. We find that k-approval leads to
the best user experience. With respect to the aggregation rule,
greedy aggregation leads to outcomes that are highly sensitive
to the input format used and the fraction of the population
that participates. ES, in contrast, leads to outcomes that
are not sensitive to the type of voting format used, and these
outcomes are remarkably stable even when the majority of the
population does not participate in the election. These results
carry valuable insights for PB practitioners and social choice
researchers.

Participatory Budgeting Designs for the Real World

As the complexity of pacemaker devices continues to grow, the importance of capturing its functional correctness requirement formally cannot be overestimated. The pacemaker system specification document by \emph{Boston Scientific} provides a widely accepted set of specifications for pacemakers. 
As these specifications are written in a natural language, they are not amenable for automated verification, synthesis, or reinforcement learning of pacemaker systems. This paper presents a formalization of these requirements for a dual-chamber pacemaker in \emph{duration calculus} (DC), a highly expressive real-time specification language.
The proposed formalization allows us to automatically translate pacemaker requirements into executable specifications as stopwatch automata, which can be used to enable simulation, monitoring, validation, verification and automatic synthesis of pacemaker systems. 
The cyclic nature of the pacemaker-heart closed-loop system results in DC requirements that compile to a decidable subclass of stopwatch automata. We present shield reinforcement learning (shield RL),  a shield synthesis based reinforcement learning algorithm, by automatically constructing safety envelopes from DC specifications. 


Correct-by-Construction Reinforcement Learning of Cardiac Pacemakers from Duration Calculus Requirements

Efficient Training of Large-scale Industrial Fault Diagnostic Models through Federated Opportunistic Block Dropout

Human intelligence is beyond pattern recognition. From a single image, we’re able to explain what we see, reconstruct the scene in 3D, predict what’s going to happen, and plan our actions accordingly. In this talk, I will present our recent work on physical scene understanding—building versatile, data-efficient, and generalizable machines that learn to see, reason about, and interact with the physical world. The core idea is to exploit the generic, causal structure behind the world, including knowledge from computer graphics, physics, and language, in the form of approximate simulation engines, and to integrate them with deep learning. Here, deep learning plays two major roles: first, it learns to invert simulation engines for efficient inference; second, it learns to augment simulation engines for constructing powerful forward models. I’ll focus on a few topics to demonstrate this idea: building scene representation for both object geometry and physics; learning expressive dynamics models for planning and control; perception and reasoning beyond vision.

Learning to See the Physical World

Deep neural networks (DNNs) can easily be manipulated (by an adversary) to output drastically different predictions and can be done so in a controlled and directed way. This process is known as adversarial attack and is considered one of the major hurdles in using DNNs in high-stakes and real-world applications. Although developing methods to secure DNNs against adversaries is now a primary research focus, it suffers from limitations such as a lack of optimization generality and scalability. My research highlights will offer a holistic understanding of optimization foundations for robust AI, peer into their emerging challenges, and present recent solutions developed by my research group.

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