Singapore

Effectively modeling multimodal spatial omics data is critical for understanding tissue complexity and underlying biological mechanisms. While spatial transcriptomics, proteomics, and epigenomics capture molecular features, they lack pathological morphological context. Integrating these omics with histopathological images is thus critical for comprehensive disease tissue analysis. However, substantial heterogeneity across omics, imaging, and spatial modalities poses significant challenges. Naive fusion of semantically distinct sources often leads to ambiguous representations. Additionally, the resolution mismatch between high-resolution histology images and lower-resolution sequencing spots complicates spatial alignment. Biological perturbations during sample preparation further distort modality-specific signals, hindering accurate integration. To address these challenges, we propose Graph-guided Representation of Omics and Vision with Expert Regulation for Adaptive Spatial Multi-omics Fusion (GROVER), a novel framework for adaptive integration of spatial multi-omics data. GROVER leverages a Graph Convolutional Network encoder based on Kolmogorov–Arnold Networks to capture the nonlinear dependencies between each modality and its associated spatial structure, thereby producing expressive, modality-specific embeddings. To align these representations, we introduce a spot-feature-pair contrastive learning strategy that explicitly optimizes the correspondence across modalities at each spot. Furthermore, we design a dynamic expert routing mechanism that adaptively selects informative modalities for each spot while suppressing noisy or low-quality inputs. Experiments on real-world spatial omics datasets demonstrate that GROVER outperforms state-of-the-art baselines, providing a robust and reliable solution for multimodal integration.

AAAI 2026

GROVER: Graph-guided Representation of Omics and Vision with Expert Regulation for Adaptive Spatial Multi-omics Fusion

natural sciences

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.<br><br>

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We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

poster

In-context learning (ICL) enhances large language models (LLMs) by incorporating demonstration examples, yet its effectiveness heavily depends on the quality of selected examples. Current methods typically use text embeddings to measure semantic similarity, which often introduces bias in multi-step reasoning tasks. This occurs because text embeddings contain irrelevant semantic information and lack deeper reasoning structures. To address this, we propose **GraphIC**, a graph-based retrieval model that leverages reasoning-aware representation and specialized similarity metric for in-context example retrieval. GraphIC first constructs *thought graphs*—directed, node-attributed graphs that explicitly model reasoning steps and their dependencies—for candidate examples and queries. This approach filters out superficial semantics while preserving essential reasoning processes. Next, GraphIC retrieves examples using a novel similarity metric tailored for these graphs, capturing sequential reasoning patterns and asymmetry between examples. Comprehensive evaluations across mathematical reasoning, code generation, and logical reasoning tasks demonstrate that GraphIC outperforms 10 baseline methods. Our results highlight the importance of reasoning-aware retrieval in ICL, offering a robust solution for enhancing LLM performance in multi-step reasoning scenarios.

GraphIC: A Graph-Based In-Context Example Retrieval Model for Multi-Step Reasoning

Generative recommendation as a new paradigm is influencing the current development of recommender systems. It aims to assign identifiers that capture richer semantic and collaborative information to items, and subsequently predict item identifiers via autoregressive generation using Large Language Models (LLMs). Existing approaches primarily tokenize item text into codebooks with preserved semantic IDs through RQ-VAE, or separately tokenize different modality features of items. However, existing tokenization methods face two major challenges: $\textbf{(1)}$ Learning decoupled multi-modal features limits the quality of the semantic representation. $\textbf{(2)}$ Ignoring collaborative signals from interaction history limits the comprehensiveness of identifiers. To address these limitations, we propose a $\underline{\textbf{mu}}$lti-modal $\underline{\textbf{s}}$emantic-enhanced $\underline{\textbf{i}}$dentifier with $\underline{\textbf{c}}$ollaborative signals for generative $\underline{\textbf{rec}}$ommendation, named MusicRec. In MusicRec, we propose a tokenization approach based on shared-specific modal fusion, enabling the generated identifiers to preserve semantic information more comprehensively from all modalities. In addition, we incorporate collaborative signals from user interactions to guide identifier generation, preserving collaborative patterns in the semantic representation space. Extensive experiments on three public datasets demonstrate that MusicRec achieves state-of-the-art performance compared to existing baseline methods.

MusicRec: Multi-modal Semantic-Enhanced Identifier with Collaborative Signals for Generative Recommendation

While much research has recently focused on generating physics-based adversarial samples, a critical yet often overlooked category originates from physical failures within on-board cameras—components essential to the perception systems of autonomous vehicles. Camera failures, whether due to external stresses causing hardware breakdown or internal component faults, can directly jeopardize the safety and reliability of autonomous driving systems. Firstly, we motivate the study using two separate real-world experiments to showcase that indeed glass failures would cause the detection based neural network models to fail. Secondly, we develop a simulation-based study using the physical process of the glass breakage to create perturbed scenarios, representing a realistic class of physics-based adversarial samples. Using a finite element model (FEM)-based approach, we generate surface cracks on the camera image by applying a stress field defined by particles within a triangular mesh. Lastly, we use physically-based rendering (PBR) techniques to provide realistic visualizations of these physically plausible fractures. To assess the safety implications, we apply the simulated broken glass effects as image filters to two autonomous driving datasets- KITTI and BDD100K- as well as the large-scale image detection dataset MS-COCO. We then evaluate detection failure rates for critical object classes using CNN-based object detection models (YOLOv8 and Faster R-CNN) and a transformer-based architecture with Pyramid Vision Transformers. To further investigate the distributional impact of these visual distortions, we compute the Kullback-Leibler (K-L) divergence between three distinct data distributions, applying various broken glass filters to a custom dataset (captured through a cracked windshield), as well as the KITTI and Kaggle cats and dogs datasets. The K-L divergence analysis suggests that these broken glass filters do not introduce significant distributional shifts. Our goal is to provide a robust, physics-based methodology for generating adversarial samples that reflect real-world camera failures, with the overarching aim of improving the resilience and safety of autonomous driving systems against such physical threats.

Fractured Glass, Failing Cameras: Simulating Physics-Based Adversarial Samples for Autonomous Driving Systems

Model-based reinforcement learning (MBRL) is a crucial approach to enhance the generalization capabilities and improve the sample efficiency of RL algorithms. However, current MBRL methods focus primarily on building world models for single tasks and rarely address generalization across different scenarios. Building on the insight that dynamics within the same simulation engine share inherent properties, we attempt to construct a unified world model capable of generalizing across different scenarios, named Meta-Regularized Contextual World-Model (MrCoM). This method first decomposes the latent state space into various components based on the dynamic characteristics, thereby enhancing the accuracy of world-model prediction. Further, MrCoM adopts meta-state regularization to extract unified representation of scenario-relevant information, and meta-value regularization to align world-model optimization with policy learning across diverse scenario objectives. We theoretically analyze the generalization error upper bound of MrCoM in multi-scenario settings.
We systematically evaluate our algorithm's generalization ability across diverse scenarios, demonstrating significantly better performance than previous state-of-the-art methods.

MrCoM: A Meta-Regularized World-Model Generalizing Across Multi-Scenarios

With the rapid evolution of deepfake technologies and the wide dissemination of digital media, personal privacy is facing increasingly serious security threats. Deepfake proactive forensics, which involves embedding imperceptible watermarks to enable reliable source tracking, serves as a crucial defense against these threats. Although existing methods show strong forensic ability, they rely on an idealized assumption of single watermark embedding, which proves impractical in real-world scenarios. In this paper, we formally define and demonstrate the existence of Multi-Embedding Attacks (MEA) for the first time. When a previously protected image undergoes additional rounds of watermark embedding, the original forensic watermark can be destroyed or removed, rendering the entire proactive forensic mechanism ineffective. To address this vulnerability, we propose a general training paradigm named Adversarial Interference Simulation (AIS). Rather than modifying the network architecture, AIS explicitly simulates MEA scenarios during fine-tuning and introduces a resilience-driven loss function to enforce the learning of sparse and stable watermark representations. Our method enables the model to maintain the ability to extract the original watermark correctly even after a second embedding. Extensive experiments demonstrate that our plug-and-play AIS training paradigm significantly enhances the robustness of various existing methods against MEA. Our code will be released upon acceptance.

Uncovering and Mitigating Destructive Multi-Embedding Attacks in Deepfake Proactive Forensics

With recent advancements in next-generation data storage, especially in biological molecule-based storage, insertion, deletion, and substitution (IDS) error-correcting codes have garnered increased attention. However, a universal method for designing tailored IDS-correcting codes across varying channel settings remains underexplored. We present an autoencoder-based approach, THEA-code, aimed at efficiently generating IDS-correcting codes for complex IDS channels. In the work, a disturbance-based discretization is proposed to discretize the features of the autoencoder, and a simulated differentiable IDS channel is developed as a differentiable alternative for IDS operations. These innovations facilitate the successful convergence of the autoencoder, producing channel-customized IDS-correcting codes that demonstrate commendable performance across complex IDS channels, particularly in realistic DNA-based storage channels.

Disturbance-based Discretization, Differentiable IDS Channel, and an IDS-Correcting Code for DNA-based Storage

Domain generalization in semantic segmentation faces challenges from domain shifts, particularly under adverse conditions. While diffusion-based data generation methods show promise, they introduce inherent misalignment between generated images and semantic masks. This paper presents FLEX-Seg (FLexible Edge eXploitation for Segmentation), a framework that transforms this limitation into an opportunity for robust learning. FLEX-Seg comprises three key components: (1) Granular Adaptive Prototypes (GAP) that captures boundary characteristics across multiple scales, (2) Uncertainty Boundary Emphasis (UBE) that dynamically adjusts learning emphasis based on prediction entropy, and (3) Hardness-Aware Sampling (HAS) that progressively focuses on challenging examples. By leveraging inherent misalignment rather than enforcing strict alignment, FLEX-Seg learns robust representations while capturing rich stylistic variations. Experiments across five real-world datasets demonstrate consistent improvements over state-of-the-art methods, achieving 2.44% and 2.63% mIoU gains on ACDC and Dark Zurich. Our findings validate that adaptive strategies for handling imperfect synthetic data lead to superior domain generalization.

Do We Need Perfect Data? Leveraging Noise for Domain Generalized Segmentation

All-in-one image restoration (AIR) aims to address diverse degradations within a unified model by leveraging informative degradation conditions to guide the restoration process. However, existing methods often rely on implicitly learned priors, which may entangle feature representations and hinder performance in complex or unseen scenarios. Histogram of Oriented Gradients (HOG) as a classical gradient representation, we observe that it has strong discriminative capability across diverse degradations, making it a powerful and interpretable prior for AIR. Based on this insight, we propose HOGformer, a Transformer-based model that integrates learnable HOG features for degradation-aware restoration. The core of HOGformer is a Dynamic HOG-aware Self-Attention (DHOGSA) mechanism, which adaptively models long-range spatial dependencies conditioned on degradation-specific cues encoded by HOG descriptors. To further adapt the heterogeneity of degradations in AIR, we propose a Dynamic Interaction Feed-Forward (DIFF) module that facilitates channel–spatial interactions, enabling robust feature transformation under diverse degradations. Besides, we propose a HOG loss to explicitly enhance structural fidelity and edge sharpness. Extensive experiments on a variety of benchmarks, including adverse weather and natural degradations, demonstrate that HOGformer achieves state-of-the-art performance and generalizes well to complex real-world scenarios.

Gradient as Conditions: Rethinking HOG for All-in-one Image Restoration

Interactive 3D segmentation embodies an advanced human-in-the-loop paradigm, where a model iteratively refines the segmentation of interested objects within a 3D point cloud through user feedback. Existing methods have achieved notable advancements at the expense of substantial resource consumption. To address this challenge, we introduce E$^2$I3D, an efficient and effective model for interactive 3D segmentation. Specifically, we propose a two-stage efficiency-to-effectiveness framework to decouple efficiency and effectiveness, avoiding the high training cost of joint optimization. For efficiency in the first stage, we present heterogeneous pruning, which reliably compresses the model by ranking and pruning the constructed heterogeneous groups separately based on gradient compensation. For effectiveness in the second stage, we design hierarchical click-aware attention that integrates geometric details from high-resolution features with global context from low-resolution features to enhance click-guided interaction. Extensive experiments across public datasets demonstrate that E$^2$I3D exceeds state-of-the-art methods in both efficiency and effectiveness. For instance, on the KITTI-360 dataset, E$^2$I3D boosts the IoU for interactive single-object segmentation from 44.4% to 49.0% with 5 user clicks, while simultaneously reducing parameters from 39.3M to 5.7M.

Towards Efficient and Effective Interactive 3D Segmentation

To facilitate the large-scale deployment of autonomous driving in real-world scenarios, developing low-cost and highperformance 3D object detection systems has become a critical technical challenge. Although high-beam LiDARs provide denser point cloud data, their prohibitive hardware cost and high power consumption limit their practicality. In contrast, low-beam LiDARs offer advantages in terms of affordability and energy ef-ficiency, but often suffer from inadequate perception accuracy due to their sparser point cloud data. This pa-per focuses on the task of multimodal 3D object detec-tion with low-beam LiDARs, and proposes a novel ap-proach that integrates temporal and spatial representa-tion learning to enhance detection accuracy under sparser sensor conditions. Specifically, our approach comprises: (1) a Temporal Feature Prediction Learning (TFPL) module, which predicts the current BEV repre-sentation based on a sequence of historical BEV fea-tures; (2) a Spatial Feature Observation Learning (SFOL) module, which aligns BEV (Bird’s-EyeView) features from high-beam and low-beam LiDAR to enforce the low-beam features to approximate high-beam represen-tations; (3) an Uncertainty-Aware Fusion (UAF) strate-gy, which performs feature-wise weighting between the predicted and observed BEV features by leveraging channelwise variances, effectively mitigating perturba-tions in the learned BEV representations. Extensive ex-periments on the KITTI and nuScenes 3D object detec-tion datasets demonstrate that the proposed approach significantly improves detection performance under low-beam LiDAR configurations.

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