Singapore

Understanding enzyme thermal properties is essential for biotechnology and protein engineering, yet experimental measurements of attributes such as temperature optimum, stability, and range remain labor-intensive and costly. Prior studies have shown that specific regions within enzyme sequences disproportionately influence thermal behavior—an aspect often overlooked by existing deep learning models. In this work, we introduce PatchET, a biologically inspired deep learning model that predicts enzyme thermal properties directly from amino acid sequences. PatchET employs a dual-stage, patch-based architecture that captures both intra-patch local features and inter-patch global dependencies, reflecting the hierarchical nature of protein thermal adaptation. Alongside the model, we curate a comprehensive benchmark, including a refined dataset for temperature optimum and the first publicly available dataset for temperature range prediction. PatchET achieves state-of-the-art performance across three key tasks—temperature optimum, stability, and range—and serves as the first dedicated model for temperature range prediction. Extensive ablation studies further validate the effectiveness of our architectural design. Together, PatchET and the accompanying benchmark provide a unified and generalizable framework for modeling enzyme thermal properties, offering new tools for the rational design of thermostable enzymes.

AAAI 2026

PatchET: Learning Enzyme Temperature Properties Through Patch-Based Neural Architectures

enzyme temperature properties

patching

bio-inspired learning

It is my great pleasure and honor to welcome you to the 64th Annual Meeting of the Association for Computational Linguistics (ACL 2026), held in San Diego, California, USA, July 2–7, 2026. ACL 2026 continues our fields tradition of excellence in scholarship, innovation, and inclusivity, and I am deeply grateful to the many volunteers who have worked tirelessly to bring this event to life.

It is exciting to see the many developments in the field reflected at our conference, such as the advancement of large language models (born out of our community) into many application directions. This is not without challenges, partly due to unsolved problems, and partly due to misuse of the technology. All this is reflected well at ACL 2026. The conference also reflects that the field is not only about advancing technology, but also the science of fundamentally understanding language and how it is use by many different speaker communities. 
[Full Message from General Chair Philipp Koehn](https://drive.google.com/file/d/1QiJFOmMjvDgsDo3i1XzlQnImxe3RU_Cy/view?usp=sharing) 
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ACL 2026

The 64th Annual Meeting of the Association for Computational Linguistics (ACL 2026) will take place in San Diego, California, from July 2 - 7, 2026.

poster

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

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We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

Vision large language models (VLLMs) are focusing primarily on handling complex and fine-grained visual information by incorporating advanced vision encoders and scaling up visual models. However, these approaches face high training and inference costs, as well as challenges in extracting visual details, effectively bridging across modalities. In this work, we propose a novel visual framework, **MoCHA**, to address these issues. Our framework integrates four vision backbones (i.e., CLIP, SigLIP, DINOv2 and ConvNeXt) to extract complementary visual features and is equipped with a sparse **M**ixture **o**f Experts **C**onnectors (MoECs) module to dynamically select experts tailored to different visual dimensions. To mitigate redundant or insufficient use of the visual information encoded by the MoECs module, we further design a **H**ierarchical Group **A**ttention (HGA) with intra- and inter-group operations and an adaptive gating strategy for encoded visual features. We train MoCHA on two mainstream LLMs (e.g., Phi2-2.7B and Vicuna-7B) and evaluate their performance across various benchmarks. Notably, MoCHA outperforms state-of-the-art open-weight models on various tasks. For example, compared to CuMo (Mistral-7B), our MoCHA (Phi2-2.7B) presents outstanding abilities to mitigate hallucination by showing improvements of 3.25% in POPE and to follow visual instructions by raising 158 points on MME. Finally, ablation studies further confirm the effectiveness and robustness of the proposed MoECs and HGA in improving the overall performance of MoCHA. Code is available in the supplementary material.

MoCHA: Advanced Vision-Language Reasoning with MoE Connector and Hierarchical Group Attention

In controllable image synthesis, generating coherent and consistent images from multiple references with spatial layout awareness remains an open challenge. We propose LAMIC, a Layout-Aware Multi-Image Composition framework that, for the first time, extends single-reference diffusion models to multi-reference scenarios in a training-free manner. Built upon the MMDiT model, LAMIC introduces two plug-and-play attention mechanisms: 1) Group Isolation Attention (GIA) to enhance entity disentanglement; and 2) Region-Modulated Attention (RMA) to enable layout-aware generation. To comprehensively evaluate model capabilities, we further introduce three metrics: 1) Inclusion Ratio (IN-R) and Fill Ratio (FI-R) for assessing layout control; and 2) Background Similarity (BG-S) for measuring background consistency. Extensive experiments show that LAMIC achieves state-of-the-art performance across most major metrics: it consistently outperforms existing multi-reference baselines in ID-S, BG-S, IN-R and AVG scores across all settings, and achieves the best DPG in complex composition tasks. These results demonstrate LAMIC's superior abilities in identity keeping, background preservation, layout control, and prompt-following, all achieved without any training or fine-tuning, showcasing strong zero-shot generalization ability. By inheriting the strengths of advanced single-reference models and enabling seamless extension to multi-image scenarios, LAMIC establishes a new training-free paradigm for controllable multi-image composition. As foundation models continue to evolve, LAMIC's performance is expected to scale accordingly.

LAMIC: Layout-Aware Multi-Image Composition via Scalability of Multimodal Diffusion Transformer

Recently, with the increasing capabilities of Large Language Models (LLMs), AI applications have gradually emerged to solve various problems in people's daily lives, so accurately measuring their performance and reliability is paramount. However, existing benchmarks predominantly rely on closed-ended, multiple-choice or short-answer question formats. While useful for assessment, these formats exhibit a significant gap compared to the diverse and open-ended nature of questions posed by real-world users. To bridge this gap, we produce OmniBench, a comprehensive open-domain benchmark. OmniBench is uniquely composed of authentic, user-generated questions harvested from real-world interactions on various websites and applications, covering 16 rigorously defined knowledge domains and 5 crucial user intents derived from a large-scale analysis of the mass corpus. Crucially, we propose three automated data construction pipelines that enable the continuous and periodic updating of the benchmark dataset. This approach not only ensures that the questions can keep up with current events, but also effectively mitigates the critical issue of data contamination prevalent in static benchmarks. Moreover, a multi-dimensional hybrid evaluation framework named OmniEval is proposed for evaluating the responses. This framework combines diverse metrics and evaluation methods to capture nuanced aspects of answer performance. Extensive validation demonstrates that this evaluation framework exhibits strong alignment with human judgments, ensuring the reliability of the benchmark results.

OmniBench: A Comprehensive Benchmark Integrating Real-World, Time-sensitive, and Multi-Hop Questions with a Multi-Dimensional Hybrid Evaluation Framework

Existing reinforcement learning methods for Chain-of-Thought reasoning suffer from two critical limitations. First, they operate as monolithic black boxes that provide undifferentiated reward signals, obscuring individual step contributions and hindering error diagnosis. Second, sequential decoding has O(n) time complexity. This makes real-time deployment impractical for complex reasoning tasks.
We present DeCoRL (Decoupled Reasoning Chains via Coordinated Reinforcement Learning), a novel framework that transforms reasoning from sequential processing into collaborative modular orchestration. DeCoRL trains lightweight specialized models to generate reasoning sub-steps concurrently, eliminating sequential bottlenecks through parallel processing. To enable precise error attribution, the framework designs modular reward functions that score each sub-step independently. Cascaded DRPO optimization then coordinates these rewards while preserving inter-step dependencies.
Comprehensive evaluation demonstrates state-of-the-art results across RM-Bench, RMB, and RewardBench, outperforming existing methods including large-scale models. DeCoRL delivers 3.8 times faster inference while maintaining superior solution quality and offers a 22.7\% improvement in interpretability through explicit reward attribution. These advancements, combined with a 72.4\% reduction in energy consumption and a 68\% increase in throughput, make real-time deployment of complex reasoning systems a reality.

DeCoRL: Decoupling Reasoning Chains via Parallel Sub-Step Generation and Cascaded Reinforcement for Interpretable and Scalable RLHF

Aligning large language models with multiple human expectations and values is crucial for ensuring that they adequately serve a variety of user needs. To this end, offline multiobjective alignment algorithms such as the Rewards-in-Context algorithm have shown strong performance and efficiency. However, inappropriate preference representations and training with imbalanced reward scores limit the performance of such algorithms. In this work, we introduce ParetoHqD that addresses the above issues by representing human preferences as preference directions in the objective space and regarding data near the Pareto front as ''high-quality'' data. For each preference, ParetoHqD follows a two-stage supervised fine-tuning process, where each stage uses an individual Pareto high-quality training set that best matches its preference direction. The experimental results have demonstrated the superiority of ParetoHqD over five baselines on two multiobjective alignment tasks.

ParetoHqD: Fast Offline Multiobjective Alignment of Large Language Models Using Pareto High-Quality Data

Zero-shot object navigation (ZSON) in unseen environments remains a challenging problem for household robots, requiring strong perceptual understanding and decision-making capabilities. While recent methods leverage metric maps and Large Language Models (LLMs), they often depend on depth sensors or prebuilt maps, limiting the spatial reasoning ability of Multimodal Large Language Models (MLLMs). Mapless ZSON approaches have emerged to address this, but they typically make short-sighted decisions, leading to local deadlocks due to a lack of historical context. We propose PanoNav, a fully RGB-only, mapless ZSON framework that integrates a Panoramic Scene Parsing module to unlock the spatial parsing potential of MLLMs from panoramic RGB inputs, and a Memory-guided Decision-Making mechanism enhanced by a Dynamic Bounded Memory Queue to incorporate exploration history and avoid local deadlocks. Experiments on the public navigation benchmark show that PanoNav significantly outperforms representative baselines in both SR and SPL metrics.

PanoNav: Mapless Zero-Shot Object Navigation with Panoramic Scene Parsing and Dynamic Memory

While text embeddings enable efficient semantic processing in LLMs, they remain vulnerable to inversion attacks that reconstruct sensitive original text. However, current defense methods typically treat text embeddings from the feature level independently, ignoring the exploitation of the mutual relation among the embedding construction pipeline. To address this limitation, we propose Eguard, a framework that effectively disrupts chains of relationships between the original semantic space and defended functional space. Our improvements manifest at two levels, i.e., the global-level and local-level mutual information. At the global level, we propose to minimize the statistical dependency between protected embeddings and their original inputs, effectively decoupling sensitive content from the semantic space accessible to adversaries. At the local level, we apply keyword-antonym contrastive learning to enforce semantic discriminability within the space of downstream utility. This synergy of global privacy control and local semantic alignment allows Eguard to achieve a superior privacy-utility trade-off than traditional defenses. Our approach significantly reduces privacy risks, protecting over 95\% of tokens from inversion while maintaining high performance across downstream tasks consistent with original embeddings.

Eguard: Defending LLM Embeddings Against Inversion Attacks via Text Mutual Information Optimization

Recent advances in Transformer-based Neural Operators have enabled significant progress in data-driven solvers for Partial Differential Equations (PDEs). Most current research has focused on reducing the quadratic complexity of attention to address the resulting low training and inference efficiency. 
Among these works, Transolver stands out as a representative method that introduces Physics-Attention to reduce computational costs. Physics-Attention projects grid points into slices for slice attention, then maps them back through deslicing.
However, we observe that Physics-Attention can be reformulated as a special case of linear attention, and that the slice attention may even hurt the model performance.
Based on these observations, we argue that its effectiveness primarily arises from the slice and deslice operations rather than interactions between slices. 
Building on this insight, we propose a two-step transformation to redesign Physics-Attention into a canonical linear attention, which we call $Linear Attention Neural Operator$ (LinearNO).
Our method achieves state-of-the-art performance on six standard PDE benchmarks, while reducing the number of parameters by an average of 40.0\% and computational cost by 36.2\%. Additionally, it delivers superior performance on two challenging, industrial-level datasets: AirfRANS and Shape-Net Car.

Transolver Is a Linear Transformer: Revisiting Physics-Attention Through the Lens of Linear Attention

JPEG, as a widely used image compression standard, often introduces severe visual artifacts when achieving high compression ratios. Although existing deep learning-based restoration methods have made considerable progress, they often struggle to recover complex texture details, resulting in over-smoothed outputs. To overcome these limitations, we propose SODiff, a novel and efficient semantic-oriented one-step diffusion model for JPEG artifacts removal. Our core idea is that effective restoration hinges on providing semantic-oriented guidance to the pre-trained diffusion model, thereby fully leveraging its powerful generative prior. To this end, SODiff incorporates a semantic-aligned image prompt extractor (SAIPE). SAIPE extracts rich features from low-quality (LQ) images and projects them into an embedding space semantically aligned with that of the text encoder. Simultaneously, it preserves crucial information for faithful reconstruction. Furthermore, we propose a quality factor-aware time predictor that implicitly learns the compression quality factor (QF) of the LQ image and adaptively selects the optimal denoising start timestep for the diffusion process. Extensive experimental results show that our SODiff outperforms recent leading methods in both visual quality and quantitative metrics. The code and models will be publicly available soon.

SODiff：Semantic-Oriented Diffusion Model for JPEG Compression Artifacts Removal

Reinforcement learning (RL) has demonstrated considerable potential for enhancing reasoning in large language models (LLMs). 
However, existing methods suffer from poor data efficiency and degraded reasoning capabilities when training directly on samples with mixed difficulty. To mitigate this, prior approaches leverage Chain-of-Thought (CoT) data, but the construction of high-quality CoT annotations remains labor-intensive. Alternatively, curriculum learning strategies have been explored but frequently encounter challenges, such as difficulty mismatch, reliance on manual curriculum design, and catastrophic forgetting.
To address these issues, we propose AdaCuRL, a Adaptive Curriculum Reinforcement Learning framework that integrates coarse-to-fine difficulty estimation with adaptive curriculum scheduling. This approach dynamically aligns data difficulty with model capability and incorporates a data revisitation mechanism to mitigate catastrophic forgetting. Furthermore, AdaCuRL employs adaptive reference and sparse KL regularization strategies to prevent reasoning degradation. Extensive experiments across diverse reasoning benchmarks demonstrate that AdaCuRL consistently achieves significant performance improvements on both LLMs and MLLMs.

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MoCHA: Advanced Vision-Language Reasoning with MoE Connector and Hierarchical Group Attention

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