Singapore

While Large Language Models (LLMs) are emerging as a promising direction in computational pathology, the substantial computational cost of giga-pixel Whole Slide Images (WSIs) necessitates the use of Multi-Instance Learning (MIL) to enable effective modeling. A key challenge is that pathological tasks typically provide only bag-level labels, while instance-level descriptions generated by LLMs often suffer from bias due to a lack of fine-grained medical knowledge. To address this, we propose that constructing task-specific pathological entity prototypes is crucial for learning generalizable features and enhancing model interpretability. Furthermore, existing vision-language MIL methods often employ unidirectional guidance, limiting cross-modal synergy. In this paper, we introduce a novel approach, Multimodal Prototype-based Multi-Instance Learning, that promotes bidirectional interaction through a balanced information compression scheme. Specifically, we leverage a frozen LLM to generate task-specific pathological entity descriptions, which are learned as text prototypes. Concurrently, the vision branch learns instance-level prototypes to mitigate the model&#39;s reliance on redundant data. For the fusion stage, we employ the Stereoscopic Optimal Transport (SOT) algorithm, which is based on a similarity metric, thereby facilitating broader semantic alignment in a higher-dimensional space. We conduct few-shot classification and explainability experiments on three distinct cancer datasets, and the results demonstrate the superior generalization capabilities of our proposed method. Code will be made available.

AAAI 2026

Libra-MIL: Multimodal Prototypes Stereoscopic Infused with Task-specific Language Priors for Few-shot Whole Slide Image Classification

ml: multi-instance/multi-view learning

ml: multimodal learning

cv: medical and biological imaging

We are pleased to announce the Thirty-Eighth AAAI Conference on Artificial Intelligence (AAAI-24), which will be held in Vancouver, British Columbia at the Vancouver Convention Centre – West Building from 20-27 February, 2024.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-24 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

We expect for AAAI-24 to be an in-person conference – one author of all accepted papers will be expected to present work in person unless there are exceptional circumstances that prevent this.

In order to access the AAAI-24 event page you need to register [here](https://aaai.org/aaai-conference/registration/)

AAAI 2024

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. 

While Large Language Models (LLMs) are emerging as a promising direction in computational pathology, the substantial computational cost of giga-pixel Whole Slide Images (WSIs) necessitates the use of Multi-Instance Learning (MIL) to enable effective modeling. A key challenge is that pathological tasks typically provide only bag-level labels, while instance-level descriptions generated by LLMs often suffer from bias due to a lack of fine-grained medical knowledge. To address this, we propose that constructing task-specific pathological entity prototypes is crucial for learning generalizable features and enhancing model interpretability. Furthermore, existing vision-language MIL methods often employ unidirectional guidance, limiting cross-modal synergy. In this paper, we introduce a novel approach, Multimodal Prototype-based Multi-Instance Learning, that promotes bidirectional interaction through a balanced information compression scheme. Specifically, we leverage a frozen LLM to generate task-specific pathological entity descriptions, which are learned as text prototypes. Concurrently, the vision branch learns instance-level prototypes to mitigate the model's reliance on redundant data. For the fusion stage, we employ the Stereoscopic Optimal Transport (SOT) algorithm, which is based on a similarity metric, thereby facilitating broader semantic alignment in a higher-dimensional space. We conduct few-shot classification and explainability experiments on three distinct cancer datasets, and the results demonstrate the superior generalization capabilities of our proposed method. Code will be made available.

poster

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

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We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

Recent years have witnessed the wide adoption of deep learning recommendation models (DLRMs) for many online services. Unlike traditional DNN training, DLRMs leverage massive embeddings to represent sparse features, which are stored in distributed GPUs following the model parallel paradigm. Existing approaches adopt deduplication to eliminate replicated embeddings involved in AltoAll transfers to avoid unnecessary communication. In our practices, we have observed that such a deduplication design exacerbates interconnect inefficiency due to the fragmented embedding transfers with reduced message sizes, hindering the performance of distributed DLRM training.

This paper introduces FUSEDREC, a fused embedding communication and lookup mechanism to tackle the inefficiency due to deduplication. By seeking the opportunities to fuse embeddings from multiple categories into a group, FUSEDREC conducts the communication in a combined shot to alleviate bandwidth under-utilization. Meanwhile, a categorical-aware hashing algorithm is integrated into FUSEDREC to retain the category information during lookup without extra communication. Combining with efficient unique and recovery operations, comprehensive results show FUSEDREC achieves a 37.8% throughput speedup in average compared to the SOTA industry implementation, without hurting the recommendation qualities of our in-house models used in online production environments.

FusedRec: Fused Embedding Communication for Distributed Recommendation Training on GPUs

The quadratic complexity of Multimodal Large Language Models (MLLMs) with respect to context length poses significant computational and memory challenges, hindering their real-world deployment.
In the paper, we devise a ``\textbf{\textit{filter-correlate-compress}}'' framework to accelerate the MLLM by systematically optimizing multimodal context length during prefilling. The framework first implements \textbf{\textit{FiCoCo-V}}, a training-free method operating within the vision encoder.
It employs a redundancy-based token discard mechanism that uses a novel integrated metric to accurately \textit{filter} out redundant visual tokens.
To mitigate information loss, the framework introduces a correlation-based information recycling mechanism that allows preserved tokens to selectively recycle information from \textit{correlate}d discarded tokens with a self-preserving \textit{compress}ion, thereby preventing the dilution of their own core content. The framework's \textbf{\textit{FiCoCo-L}} variant further leverages task-aware textual priors to perform token reduction directly within the LLM decoder. Extensive experiments demonstrate that the \textit{FiCoCo} series effectively accelerates a range of MLLMs, achieves up to \textbf{14.7×} FLOPs reduction with \textbf{93.6\%} performance retention. Our methods consistently outperform state-of-the-art training-free approaches, showcasing effectiveness and generalizability across model architectures, sizes, and tasks without requiring retraining. \textit{Code is available in supplementary materials.}

Filter, Correlate, Compress: Training-Free Token Reduction for MLLM Acceleration

Despite its success in enriching LLMs with external knowledge, RAG remains plagued by faithfulness hallucinations, where generated text contradicts the retrieved source information. Previous research on faithfulness hallucination in LLMs is frequently hindered by prohibitive manual annotation costs and a dependency on static datasets, which caps their performance and adaptability. Furthermore, these models lack a clear training mechanism to explicitly promote contextual focus. In this work, we propose a novel iterative self-evolution framework to enhance model faithfulness. This framework autonomously generates high-quality data and leverages it for the continuous self-optimization of the model, leading to significant improvements in faithfulness. Our experimental analysis reveals that improving model faithfulness encourages a closer alignment of the attention distribution with the given context. Based on this finding, we design an attention-based loss function to further promote this process. Experimental results show that our model achieves state-of-the-art faithfulness on a range of context-based question-answering datasets, marking a significant advancement over previous approaches.

REFO: Reinforced Evolutionary Faithfulness Optimization for Large Language Models

Parameter-efficient fine-tuning (PEFT) methods, such as LoRA, DoRA, and HiRA, enable lightweight adaptation of large pre-trained models via low-rank updates. However, existing PEFT approaches apply static, input-agnostic updates to all tokens, disregarding the varying importance and difficulty of different inputs. This uniform treatment can lead to overfitting on trivial content or under-adaptation on more informative regions, especially in autoregressive settings with distinct prefill and decoding dynamics. In this paper, we propose GateRA, a unified framework that introduces token-aware modulation to dynamically adjust the strength of PEFT updates. By incorporating adaptive gating into standard PEFT branches, GateRA enables selective, token-level adaptation—preserving pre-trained knowledge for well-modeled inputs while focusing capacity on challenging cases. Empirical visualizations reveal phase-sensitive behaviors, where GateRA automatically suppresses updates for redundant prefill tokens while emphasizing adaptation during decoding. To promote confident and efficient modulation, we further introduce an entropy-based regularization that encourages near-binary gating decisions. This regularization prevents diffuse update patterns and leads to interpretable, sparse adaptation without hard thresholding. Finally, we present a theoretical analysis showing that GateRA induces a soft gradient-masking effect over the PEFT path, enabling continuous and differentiable control over adaptation. Experiments on multiple commonsense reasoning benchmarks demonstrate that GateRA consistently outperforms or matches prior PEFT methods.

GateRA: Token-aware Modulation for Parameter-Efficient Fine-tuning

Language-conditioned manipulation facilitates human-robot interaction via behavioral cloning (BC), which learns control policies from human demonstrations and serves as a cornerstone of embodied AI. Overcoming compounding errors in sequential action decisions remains a central challenge to improving BC performance. Existing approaches mitigate compounding errors through data augmentation, expressive representation, or temporal abstraction. However, they suffer from physical discontinuities and semantic-physical misalignment, leading to inaccurate action cloning and intermittent execution. In this paper, we present Continuous vision-language-action Co-Learning with Semantic-Physical Alignment (CCoL), a novel BC framework that ensures temporally consistent execution and fine-grained semantic grounding. It generates robust and smooth action execution trajectories through continuous co-learning across vision, language, and proprioceptive inputs (i.e., robot internal states). Meanwhile, we anchor language semantics to visuomotor representations by a bidirectional cross-attention to learn contextual information for action generation, successfully overcoming the problem of semantic-physical misalignment. Extensive experiments show that CCoL achieves an average 8.05\% relative improvement across three simulation suites, with up to 19.2\% relative gain in human-demonstrated bimanual insertion tasks. Real-world tests on a 7-DoF robot further confirm CCoL’s generalization under unseen and noisy object states.

Continuous Vision-Language-Action Co-Learning with Semantic-Physical Alignment for Behavioral Cloning

Protein-Ligand Affinity (PLA) prediction quantifies interaction strength to guide rational drug design. Existing approaches typically analyze protein-ligand interaction at a single granularity and overlook their tightly coupled relationships in both structure and functionality, consequently yielding suboptimal representations, leading to significant performance drops in real-world scenarios. To address this problem, we propose PLA-MGRA, a minimalist and effective PLA prediction framework. Specifically, PLA-MGRA captures both fine-grained atomic details and coarse-grained functional semantics within the 3D structure of protein–ligand complexes, through multi-granularity learning. To further parse the coupled protein–ligand relationships, we design relation-aware learning for enhancing binding nature of representations. Extensive experiments demonstrate our method achieves state-of-the-art performance on multiple protein–ligand affinity prediction benchmarks, while also offering generalizability and interpretability.

PLA-MGRA: Multi-Granularity and Relation-Aware Learning for Efficient and Generalizable Protein-Ligand Binding Affinity Prediction

Continual Generalized Category Discovery (C-GCD) requires identifying novel classes from unlabeled data while retaining knowledge of known classes over time. Existing methods typically update classifier weights dynamically, resulting in forgetting and inconsistent feature alignment. We propose GOAL, a unified framework that introduces a fixed Equiangular Tight Frame (ETF) classifier to impose a consistent geometric structure throughout learning. GOAL conducts supervised alignment for labeled samples and confidence-guided alignment for novel samples, enabling stable integration of new classes without disrupting old ones. Experiments on four benchmarks show that GOAL outperforms the prior method Happy, reducing forgetting by 16.1% and boosting novel class discovery by 3.2%, establishing a strong solution for long-horizon continual discovery.

GOAL: Geometrically Optimal Alignment for Continual Generalized Category Discovery

Robust signal enhancement under nonstationary and low SNR conditions remains challenging, as methods based on the short-time Fourier transform (STFT) with fixed resolution struggle to represent complex and time–frequency structures. While leveraging the fractional domain as an auxiliary view offers flexibility in modeling time-frequency structures, existing methods typically adopt fixed transform orders and overlook alignment between views, hindering effective integration of complementary representations and leaving frequency domain misalignment unresolved. Therefore, we propose FracFusion, a novel framework that integrates a learnable short time fractional Fourier Transform (STFrFT) module to generate dynamic auxiliary views, combined with two stage alignment-aware fusion modules: Pearson Channel Fusion for correlation-guided consistency and Efficient Align Fusion for fine-grained, frequency aligned interaction. Experiments on speech and EM datasets show that FracFusion consistently outperforms state-of-the-art baselines across diverse noise levels and signal types, demonstrating robust adaptability across domains.

Signal Enhancement via Multi-view Dynamic Representation and Alignment-aware Fusion

Diffusion models have become a leading class of generative models, especially conditional ones that support prompt-driven image synthesis. While recent research emphasizes the pivotal role of noise seeds in enhancing text-image alignment and generating human-preferred outputs, current approaches predominantly rely on random Gaussian noise or heuristic local adjustments, lacking a comprehensive global optimization framework. To bridge this gap, we propose Seed Optimization based on Evolution (SOE), a novel hybrid approach integrating a global search mechanism—an evolutionary algorithm coupled with multi-scale random sampling, guided by a dual-seed evaluation framework combining CLIP-based text-image alignment scores and ImageReward-based human-preference rewards—and a local refinement strategy that employs inversion techniques to inject conditional information into noise seeds. This local optimization leverages the diffusion inversion process to encode prompt semantics into noise.
Extensive experiments across various diffusion models validate the effectiveness and generalizability of SOE in optimizing noise seeds.

Dual-Seed Evolutionary Algorithm for Noise Optimization in Diffusion Models

Radiology report generation from longitudinal medical data is critical for assessing disease progression and automating diagnostic workflows. While recent methods incorporate longitudinal information, they primarily rely on multimodal feature fusion, with limited capacity for explicit disease evolution modeling and temporal reasoning. To address this, we propose MARE, an end-to-end framework that formulates longitudinal radiology report generation as a multimodal analogical reasoning task. Inspired by the Abduction–Mapping–Induction paradigm, MARE models latent relational structures underlying disease evolution by aligning lesion-level visual features across time and mapping them to the textual domain for temporally coherent and clinically meaningful report generation. To mitigate the spatial misalignment caused by patient positioning or imaging variation, we introduce an Adaptive Region Alignment (ARA) module for robust temporal correspondence. Additionally, we design Dual Evolution Consistency (DEC) losses to regularize analogical reasoning by enforcing temporal coherence in both visual and textual evolution paths. Extensive experiments on the Longitudinal-MIMIC dataset demonstrate that MARE significantly outperforms state-of-the-art baselines across both natural language generation and clinical effectiveness metrics, highlighting the value of structured analogical reasoning for disease evolution-aware report generation.
Code will be released upon publication.

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