United States

Abstract Title 
Primary Pancreatic Liposarcoma: A Rare Case and Presentation 

Background 
Primary pancreatic liposarcoma is an extremely rare malignancy, with fewer than ten documented cases between 1979 and 2016. Unlike more common epithelial pancreatic neoplasms, these tumors arise from mesenchymal tissue and often present diagnostic and management challenges. This is due to their rarity, variable imaging characteristics, and absence of standardized treatment protocols. This case offers insight into hospital-based diagnostic workup, imaging studies, and complex surgical management of a rare and aggressive tumor, highlighting several dilemmas frequently encountered in clinical practice. 

Case Presentation 
A 64-year-old woman with a history of breast cancer and a benign thyroid nodule presented with upper abdominal and back pain. Laboratory studies showed elevated alkaline phosphatase, with otherwise unremarkable tumor markers. CT imaging revealed a 10.0 cm heterogeneously enhancing pancreatic tail mass with coarse calcifications causing mass effect on the left kidney. Endoscopic ultrasound-guided fine-needle aspiration confirmed a hyperechoic mass with calcifications; pathology demonstrated malignant cells and osteoblast-like giant cells, consistent with dedifferentiated liposarcoma. 

The patient underwent extensive surgical resection, including distal pancreatectomy, nephrectomy, adrenalectomy, and resection of adjacent bowel segments. Follow-up imaging two months post-operatively revealed multiple hypoenhancing hepatic lesions and metastatic lymphadenopathy, confirmed on biopsy to be consistent with metastatic dedifferentiated liposarcoma. Despite initial surgical success, the disease rapidly recurred locally and metastatically. Radiotherapy and chemotherapy were deferred due to the patient’s clinical decline. She passed away shortly thereafter. 

Discussion 
This case illustrates multiple clinical dilemmas relevant to patient care. Radiologically, the absence of typical liposarcoma features, such as intralesional fat, and the presence of coarse calcifications underscore the diagnostic uncertainty associated with rare tumors such as pancreatic liposarcoma. Therapeutically, it highlights the challenges of managing aggressive malignancies for which no consensus guidelines exist. Despite complete resection, the patient experienced rapid recurrence, emphasizing the limited curative potential of surgery alone in dedifferentiated pancreatic tumor subtypes. From an educational perspective, this case reinforces the importance of maintaining a broad differential diagnosis for atypical pancreatic masses and highlights the need for interdisciplinary coordination in tumor board review, surgical planning, and palliative decision-making. This case underscores the value of recognizing rare tumor variants in hospital practice, managing rapid postoperative recurrence, and balancing aggressive intervention with patient-centered care in the absence of evidence-based treatment algorithms.

AMA Research Challenge 2025 

Primary Pancreatic Liposarcoma: A Rare Case and Presentation

Welcome to the **largest national, multi-specialty research** event featuring research from more than 750 medical students, residents, fellows, and international medical graduates.

Use the buttons below or navigation menu to access the event.
<br><br><br>

[![](https://assets.underline.io/markdown_image/1/image/20e1e77aa954efeac7a15d84c85eb383.jpg)](https://underline.io/events/468/sessions?searchGroup=all)
<br>
[![](https://assets.underline.io/markdown_image/1/image/068522d81aca0b68a369787c7dfccd1b.jpg)](https://underline.io/events/468/posters?searchGroup=all)
<br>
[![](https://assets.underline.io/markdown_image/1/image/d3971ece79d5e5575b178bdc2c8bbfae.jpg)](https://underline.io/events/468/help-desk)
<br><br>

#### Event Details

The 2024 American Medical Association Research Challenge includes a poster symposium hall and a semifinals hall with the top scored research. **Log in at any time throughout the event to:**

* **View posters and presentations** on a variety of topics and specialties
* **Score posters in the semifinals** to help decide the top five finalists (AMA member exclusive opportunity)
* **Connect with participants** and provide feedback to help advance their research

At the conclusion of this event, the AMA will announce the top five finalists who will advance to the AMA Research Challenge finals, present their research to an elite panel of judges, and compete to win a $10,000 grand prize presented by Laurel Road.<br><br>

### Grand Prize Sponsor

AMA would like to thank Laurel Road for sponsoring a $10,000 grand prize for the winner of the AMA Research Challenge. Laurel Road is not involved in winner selection process. The winner will be announced on February 20, 2025 during the AMA Research Challenge finals. Payment of the grand prize will be directly from Laurel Road. See the AMA Research Challenge Official Rules for terms and conditions.

[![](https://assets.underline.io/uploads/markdown_image/1/image/611e331d4a0eba0920f240cfc04b4d77.png)](https://www.laurelroad.com/)

<br><br>

You need to log in with the email address you registered with. Access credentials have been sent to your email. 

Please be sure to check your spam and other email folders if you do not see an email confirmation right away.

Please log in to explore this event.

**There is no registration fee for this event! **

If you have used the AMA Research Challenge platform previously, please click the ‘Log-in’ button below. If you do not remember your password, please click “forgot password” and follow prompts to reset your password. After resetting your password, please refresh your webpage to access the platform.

Register to explore research in a variety of topics. AMA members get exclusive access to score posters in the semifinals. 

**Please use this link [here](https://www.ama-assn.org/member-benefits/events/ama-research-challenge) to register for free.**

Registration Is Required

AMA Research Challenge 2024 

Join the AMA Research Challenge poster symposium and semifinals to explore top research posters and score posters in the semifinals (an AMA member exclusive opportunity).

poster

Congratulations to all the researchers who have qualified for the AMA Research Challenge virtual poster symposium and semifinals!

Welcome to the **largest national, multi-specialty research event** featuring research from nearly 1,000 medical students, residents, fellows, and international medical graduates across six topic areas - basic science, clinical and translational research, clinical vignettes, health systems science, medical education, and public health and health policy.

#### Access the Event
Use the buttons below or navigation menu to access the event. 

[![](https://assets.underline.io/markdown_image/1/image/d4076f2146939317a29eb9f69c53ad41.png)](https://underline.io/events/506/sessions?searchGroup=all)
[![](https://assets.underline.io/markdown_image/1/image/6bcee0b523a4874c4292ca0415d88dde.png)](https://underline.io/events/506/posters?searchGroup=all)

#### Event Details
The 2025 AMA Research Challenge includes the following symposium halls:
* **Semifinals hall:** Features research from 54 medical students, residents and international medical graduates that received top scores during first round scoring. 
* **Poster symposium hall:** Features research from nearly 1,000 medical students, residents and international medical graduates categorized by topics and subtopics.

**Here’s how to participate:**
* **View posters and presentations** on a variety of topics and specialties
* **Score posters in the semifinals** to help decide the top five finalists (AMA member exclusive opportunity)
* **Connect with presenters** and provide feedback to help advance their research
* **New this year: Watch live poster presentations** by topic area and engage directly with researchers

At the conclusion of this event, the AMA announced the top five finalists who advanced to the AMA Research Challenge final round, presented their research to an elite panel of judges, and competed to win a $10,000 grand prize presented by Laurel Road.

**Addison Shenk, a fourth-year medical student from Edward Via Virginia College of Osteopathic Medicine, was the winner of the 2025 AMA Research Challenge and was awarded the grand prize of $10,000, presented by Laurel Road.**

#### A message from Dr. Bobby Mukkamala, AMA President
<div style="position: relative; width: 100%; padding-bottom: 56.25%; height: 0; overflow: hidden;">
  <iframe 
    src="https://underline.io/embed/136894-ama-video?t=0"
    title="AMA Welcome Video"
    allowfullscreen
    style="position: absolute; top: 0; left: 0; width: 100%; height: 100%; border: 0;">
  </iframe>
</div>


#### Recognized Institutions
In 2025, 1,400 abstracts were submitted across six topic areas representing 174 medical schools and more than 150 residency and health care institutions. [See if your institution is represented this year!](https://drive.google.com/file/d/1eFrTqCmCeobx9pr5drJK2hllvsIpFNOY/view?usp=drive_link)

#### Grand Prize Sponsor
AMA would like to thank Laurel Road, a brand of KeyBank, for sponsoring a $10,000 grand prize for the winner of the AMA Research Challenge. Laurel Road and KeyBank are not involved in winner selection process. The winner will be announced during the AMA Research Challenge final round. Payment of the grand prize will be directly from Laurel Road/KeyBank. See the [AMA Research Challenge Official Rules for terms and conditions](https://www.ama-assn.org/system/files/research-challenge-official-rules.pdf).

[![](https://assets.underline.io/uploads/markdown_image/1/image/611e331d4a0eba0920f240cfc04b4d77.png)](https://www.laurelroad.com/)

#### Code of Conduct
<html>
AMA has a code of conduct for its meetings – we ask all attendees to adhere to this code to participate in this year’s meeting. Please read and <a href="https://www.ama-assn.org/about/code-conduct" target="_blank">learn more here</a> about your conduct requirements.
<br><br>
	</html>
	

#### Semifinals Judges

You need to log in with the email address you registered with. Access credentials have been sent to your email. 

Please be sure to check your spam and other email folders if you do not see an email confirmation right away.

Need help? Contact us at <support@underline.io>.

If you have used the AMA Research Challenge platform previously, please click the ‘Log-in’ button below. If you do not remember your password, please click “forgot password” and follow prompts to reset your password. After resetting your password, please refresh your webpage to access the platform. 

Register to explore research in a variety of topics. AMA members get exclusive access to score posters in the semifinals. 

**Please use [this link here](https://www.ama-assn.org/member-benefits/events/ama-research-challenge) to register for free. **

MicroRNAs (miRNAs) are critical regulators of gene expression. The co-expressed miRNAs, miR-24 and miR-27, are known to restrain T helper 2 (Th2) cell differentiation and the production of cytokines like Interleukin-4 (IL-4), which are central to allergic diseases. However, a comprehensive map of their target network is incomplete. High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation (HITS-CLIP) can identify miRNA targets transcriptome-wide, but analyzing these large datasets to find differential targets between conditions remains a major computational challenge. To address this, we developed DeepRNA-Reg, a novel deep learning algorithm designed for high-fidelity comparative analysis of HITS-CLIP experiments.

A Deep-Learning Based Approach Uncovers Novel Mediators of Micro-RNA Restraint of Type-2 Immunity

Background 
Medication adherence is a complex and interconnected issue. A patient is considered adherent to medication if taking 80% of their prescribed medication(s). Medication adherence places a huge economic burden on healthcare systems. An estimated annual adjusted disease-specific economic cost of non-adherence per person ranged from $949 to $44,190 in 2015.

Aim 
Our systematic review was to investigate factors affecting medication non-adherence in the adult US population (>18 years) from published literature in the last 10 years (2012-2023). 

Methods 
We performed a systematic review using the PRISMA protocol and MOOSE guidelines to identify articles describing factors affecting medication non-adherence. Using the PubMed search engine, we identified English, full-text, observational studies from 2012 to the present using the following keywords: medication non-adherence, economic impact, factors associated with drug non-adherence, and cost-related medication nonadherence. The primary endpoint was to screen, collect and analyze the data on the factors, burden, and short and long-term impact of medication non-adherence on healthcare. We have also evaluated the methods of assessment and measures of adherence. 

Results 
Of the initial pool of 982 studies describing information medication non-compliance, we found 10 full-length studies describing factors, burden, long-term impact, and method and measure of drug compliance. We found that cost-related non-adherence in adults >65 years of age, diabetics, cardiovascular disease, and hypertension had higher mortality compared to drug-adherent patients. The factors that contribute to medication compliance are broadly classified into 
patient-specific, illness-specific, medication-related, healthcare-related, sociocultural, as well as logistical and financial factors. A Systematic Review investigating cost and regimen complexity affecting medication Adherence in the elderly that included 9 studies identified patient-related factors such as disease-related knowledge, health literacy, and cognitive function, drug-related factors such as adverse effects and polypharmacy, and other factors.

Conclusion 
Medication adherence places a huge economic burden on the healthcare system's specialty amongst the population over >65 years of age. Indicators are always available to identify in each patient like polypharmacy, chronic disease, mental health, etc but those are needed to be recognized at an early level to mitigate the burden of non-adherence and reduce mortality in specific groups of the population.

Factors associated with medical non-adherence - a systematic review

Background
Atrial fibrillation (AF) affects over 10 million people in the United States and is commonly managed via antiarrhythmic drug (AAD) therapy for symptom and rhythm control. While AADs are known to improve cardiac outcomes in AF patients, they often require a three-day inpatient hospitalization to initiate treatment due to the rare risk (<0.6%) of QT prolongation. These hospitalizations can contribute significantly to healthcare costs. The goal of this case series is to present a novel software platform that supports remote AAD therapy initiation and ECG monitoring of varying durations, offering a safe and cost-effective alternative to inpatient care.

Methods
A total of 17 AF patients (7 female, 10 male) underwent software-supported AAD titration (1 dofetilide, 2 amiodarone, 14 sotalol). Baseline ECG parameters were recorded and reviewed by providers who either accepted, modified, or rejected the automated measurements through the SafeBeat Rx software portal. The physicians then approved, modified, or rejected the algorithm-recommended AAD dose, generated based on the manufacturer’s drug label. Heart rate and QTc following each dose were monitored for proarrhythmic effects. 

Results
Average baseline QTc, heart rate, and creatinine averaged 409.76 ± 20.56 ms, 83.47 ± 19.77 beats/min, and 0.95 ± 0.22 mg/dL, respectively (Table I). Remote cardiac interval monitoring ranged from 3 to 22 days. In total, 11 patients were extended to long-term remote monitoring following the drug titration process. No adverse events were reported, and all patients achieved sinus rhythm.

Conclusion
This case series establishes remote and extended QT-interval monitoring during AAD therapy initiation. All patients experienced safe and effective dose administration, suggesting the software platform has the potential to facilitate long-term cardiac therapeutic monitoring of commonly prescribed AADs.

Software-Supported Remote Monitoring of Anti-Arrhythmic Drug Therapy in Atrial Fibrillation Patients: A Case Series

Background
Prurigo nodularis (PN) is a chronic inflammatory, pruritic skin disorder characterized by raised papules and hyperkeratotic nodules. PN has been linked to malignancy, though cancer types and mechanisms remain unclear. To analyze the relationship between PN and skin cancer, we used the All of Us Research Program, a U.S.-based electronic health record and genomic database with data from over one million participants, to assess PN and cutaneous neoplasms.
Methods
We identified 869 individuals with PN using concept ID 4272156 and propensity matched them to two controls (n = 1738) based on age, sex, race, and ethnicity. Diagnoses of basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC), and melanoma were identified through curated concept sets and relevant concept IDs to maximize capture. We extracted demographic and clinical variables, smoking status, insurance, income, family skin cancer history, and healthcare use.
Univariate associations were tested using χ2 or Fisher’s exact t-test. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Multivariable logistic regression models were adjusted for age, race, ethnicity, sex, income, insurance, smoking status, family history of skin cancer, and healthcare utilization.
Results
PN cases had a higher prevalence of any NMSC (16.3% vs 5.2%; P < 0.001), with significant increases in BCC (11.4% vs 3.9%; P < 0.001), SCC (9.7% vs 1.8%; P < 0.001) and melanoma (4.3% vs 1.5%; P < 0.001). Univariable logistic regression showed PN was associated with increased odds of BCC (OR 3.16; 95% CI 2.29–4.35; P < 0.001), SCC (OR 5.89; 95% CI 3.87– 8.97; P < 0.001) and melanoma (OR 2.93; 95% CI 1.76–4.87; P < 0.001). These associations persisted after multivariable adjustment for demographics, risk factors, and healthcare utilization, with adjusted OR (aOR) 3.31 (95% CI 2.33–4.69; P < 0.001) for BCC, aOR 6.09 (95% CI 3.89– 9.53; P < 0.001) for SCC and aOR 3.01 (95% CI 1.77–5.13; P < 0.001) for melanoma.
Conclusion
Chronic scratching and repeated trauma to the skin, hallmarks of PN, may lead to inflammation and compromised skin barrier integrity, potentially promoting keratinocyte carcinogenesis. PN is associated with a chronic Th2-skewed inflammatory milieu—characterized by elevated IL-4 and IL-13, and prolonged use of immunosuppressants may similarly impair antitumor immunity. Future PN studies should examine IL-4/IL-13 pathway inhibitors on long-term cancer risk. Given the potential association with cutaneous neoplasms, routine skin exams may be appropriate in individuals with long-standing or extensive PN.

Risk of Skin Cancer in Prurigo Nodularis: A Case-Control Study Using the All of Us Research Program

Abstract Title
Interventions to Improve Post-Acute Care Linkage to Outpatient Treatment for Alcohol Use Disorder: A Systematic Review 

Ariyani Challapalli, BA1; Lisa Bero, PhD2; Kelsey Hills-Dunlap, MD3; Susan L. Calcaterra, MD, MPH, MS4,5; E. Jennifer Edelman, MD, MHS6,7; Gina R. Kruse, MD, MS, MPH5, Ben Harnke MLIS8; Eden Y. Bernstein, MD, MPH4

1 University of Colorado School of Medicine, Aurora, CO, USA
2 Center for Bioethics and Humanities, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
3 Division of Pulmonary Sciences & Critical Care, Department of Medicine, University of Colorado, Aurora, CO, USA
4 Division of Hospital Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA
5 Division of General Internal Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA
6 Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
7 Program in Addiction Medicine, Yale School of Medicine, New Haven, CT, USA.
8 Health Sciences Library, University of Colorado Anschutz Medical Campus, Aurora, CO, USA



Background
In the United States, alcohol use contributes to nearly 180,000 annual deaths, and over 2 million adults with alcohol use disorder (AUD) are hospitalized annually. While hospitalizations provide opportunities for AUD treatment engagement, fewer than half of patients with AUD attend outpatient follow-up after discharge. We are conducting a systematic review to synthesize evidence regarding interventions that facilitate linkage to outpatient AUD treatment following acute care admissions. 

Methods
We conducted a search for English language observational studies and randomized trials published from January 2000 to February 2025 that included MeSH and text (title/abstract) terms for AUD, outpatient treatment, and acute care admissions. Two reviewers evaluated studies for inclusion in a two-phase process (title/abstract followed by full text) based on pre-defined criteria related to outcomes, study design, population, setting, and publication eligibility. Ongoing studies from ClinicalTrials.gov from January 2019 to January 2025 were included. Other database sources were Ovid MEDLINE, Embase, PsycINFO, CINAHL, and Cochrane CENTRAL. Outcome criteria involved presence of a reported linkage to outpatient care defined as attendance to a setting where AUD treatment can be delivered, including primary care or specialty addiction treatment. Population included studies with adults age ≥18 years and >50% diagnosed with AUD or alcohol dependence. Setting included acute care admissions to hospitals and detoxification facilities but excluded residential treatment and emergency department visits. 

Results
The database search identified 4,827 unique citations, of which 4,720 were excluded during title and abstract review. Of the remaining 107 articles, 80 were excluded during full-text review: 33 (41%) were excluded due to lack of linkage to care outcome, 22 (28%) for study design, 15 (19%) for population, 8 (10%) for publication ineligibility, and 2 (3%) for setting. Of the 27 studies that met inclusion criteria, 16 (59%) were randomized controlled trials, 5 (19%) were non-randomized trials, 4 (15%) were ongoing studies, and 2 (7%) were observational studies. Of the interventions, 11 (41%) included brief interventions or motivational interviewing, 5 (19%) included medication initiation, 5 (19%) included peer or family member intervention, 4 (15%) included digital interventions, and 3 (7%) included referral strategies for outpatient treatment. Data extraction is ongoing. 


Conclusion
In this comprehensive systematic review, we identified 27 studies, including 16 randomized controlled trials, that describe interventions to link patients hospitalized with AUD to outpatient treatment. Ongoing data extraction will inform system-level design and implementation of interventions to improve outcomes in this population. 


Interventions to Improve Post-Acute Care Linkage to Outpatient Treatment for Alcohol Use Disorder: A Systematic Review

The Physician Payments Sunshine Act (2010) increased transparency in physician–industry financial relationships. This study examined industry payments to orthopaedic residency program directors (RPDs) and department chairs (RPCs) using Open Payments data from 2017–2023. Among 209 programs (209 PDs, 169 DCs), 95% received 41,465 payments totaling $126.3M. Most payments were under $1,000 and for Food & Beverage (PDs 60.7%, DCs 47.5%). Trauma RPDs and Arthroplasty RPCs had the highest average payments, while Trauma specialists received the greatest total. Funding was predominantly from Smith & Nephew (26%) and Stryker (21.6%), and disproportionately directed to males (91.1%) and MDs (88.9%). Industry funding to orthopaedic leaders is nearly universal, concentrated in certain subspecialties, and largely provided by a small number of companies.

Industry Payments to Orthopaedic Surgery RPDs and RPCs

Abstract Title
Non-Surgical Management of a Partial ACL Tear with Platelet-Rich Plasma: A Case Report

Background
Anterior cruciate ligament (ACL) injuries are common in pivoting sports and often result in long-term functional limitations. While complete ACL tears typically require surgical intervention, partial tears in active individuals may benefit from biologic therapies. We present a case of a recreational athlete with a partial ACL tear managed successfully with platelet-rich plasma (PRP) therapy.

Methods
A 29-year-old male recreational basketball player presented with acute right knee pain after landing awkwardly from a jump. He reported a mild "pop" sensation, immediate swelling, and difficulty bearing weight. He had no prior history of major knee injury. Initial conservative management included RICE and NSAIDs. Due to persistent pain and instability after 3 weeks, he was referred for further evaluation.

Results
Physical examination revealed mild effusion, tenderness along the medial joint line, and mild limitations in flexion and extension. Lachman test was mildly positive; anterior drawer test showed minimal translation. MRI demonstrated a partial tear of the ACL involving approximately 50% of the ligament fibers, with intact menisci and collateral ligaments. No chondral defects were noted. Given the partial nature of the injury and the patient's desire to avoid surgery, PRP therapy was recommended. The patient received two ultrasound-guided intra-ligamentous PRP injections over a four-week interval.

Conclusion
At the 3-month follow-up, the patient reported significant improvement in knee stability and function, with minimal pain. MRI demonstrated improved fiber continuity and decreased signal intensity in the ACL region. By 4 months post-injection, the patient had resumed non-contact basketball activity and continued with progressive strengthening and proprioception training. This case highlights the potential role of PRP therapy as a non-surgical treatment option in partial ACL tears, particularly in motivated patients seeking to return to activity. Further research is needed to better define indications and long-term outcomes of biologic therapies in ligamentous injuries.

Non-Surgical Management of a Partial ACL Tear with Platelet-Rich Plasma: A Case Report

The COVID-19 pandemic accelerated telemedicine use, offering critical healthcare access for individuals with chronic illnesses while alos exposing disparities among marginalized communities. In Flint, Michigan, a city with high poverty rates and ongoing recovery from the Water Crisis, our study sought to understand community perceptions of telemedicine. The first phase focused on English-speaking participants, revealing barriers such as lack of equipment, internet access, and awareness, alongside benefits of convenience and safety. This second phase centers on spanish-speaking residents to explore their unique, culturally specific challenges and ensure their voices shape equitable healthcare solutions.

COVID-19 and Telemedicine: Perspective from the Spanish-speaking Community in Flint, MI: A qualitative approach

In the U.S., firearms are a leading cause of traumatic injury and mortality. Firearm reinjury significantly increases morbidity, healthcare utilization, and economic burden. Hospital-based violence intervention programs (HVIPs) meet firearm injury victims in a teachable moment after injury and connect patients with peer support and community services to prevent reinjury. Identifying factors that increase risk for reinjury can guide HVIP risk stratification and harm reduction strategies. Low socioeconomic status (SES) increases firearm injury risk and may confound other risk factors. Deprivation index (DI) estimates material deprivation in a census tract, correlating with SES. We describe a cohort of patients enrolled in a HVIP, including those with a history of firearm injury, to identify factors associated with reinjury.

Patients aged 0-44 presenting at our region’s level 1 adult and pediatric trauma centers for a firearm injury from October 2024 to August 2025 were eligible for enrollment. Patients completed surveys on demographics, current and prior injury, and social determinants of health. An item-level analysis of participant responses was conducted via multivariable logistic regression at 95% confidence, using prior firearm injury as predictor, adjusted for age and gender, and then compared to separate analysis also adjusting for DI. Base OR and DI – adjusted OR was compared to detect significant change, defined a priori as > 10% difference in log-OR.

A total of 122 patients enrolled, 32 with prior firearm injury. The mean age was 26.7 years and 79.5% were male. These, along with low DI, were significantly associated with having prior firearm injury. History of firearm injury was associated with not having a high school degree, knowing the perpetrator, having a family member who was previously a victim of gun violence, incident occurrence near home, and self-reported depressive symptoms. Patients who were employed were less likely to have a history of firearm injury. DI-adjusted analysis weakened an initial association with educational attainment.

These findings are supported by prior prospective investigations which identified low SES and related factors as risk factors for reinjury. Knowing the perpetrator and having a family member injured by firearms may be novel risk factors. Educational attainment was confounded by DI on this analysis. The protective effect of employment supports the goal of HVIPs to connect patients with wraparound services, including job training and employment assistance. Future investigations should evaluate novel risk factors and risk stratification tools prospectively to overcome limitations of cross-sectional design.

Identifying factors associated with firearm reinjury in a novel hospital-based violence intervention program

Background: Since 2020, first-year students at Geisinger Commonwealth School of Medicine students were required to attend the Northeastern Pennsylvania (NEPA) Trans Health Conference, an education forum where students learn directly from community members about their health experiences, fostering cultural and narrative humility to reduce the psychological harm and medical neglect gender-diverse people face. (1, 2) In 2025, attendance became optional, with the choice to either attend the conference or complete alternative coursework. Students subsequently submitted written reflections about what they learned and how it will impact their patient advocacy. 
Methods: We conducted a qualitative cross-sectional analysis of reflections submitted by medical students who attended the NEPA Trans Health conference or completed alternative coursework in 2024 and 2025. Researchers employed a constructivist grounded theory methodology to independently code de-identified reflections and applied the Delphi method to achieve consensus. (3, 4) 
Results: Reflections from 2024 demonstrated increased knowledge about the lived experience of transgender people in support of narrative humility. (5) They also demonstrated an understanding of gender-diverse patients’ needs and the ability to apply health equity frameworks to patient advocacy. Preliminary data from 2025 reveals lower conference attendance compared to 2024. We hypothesize that students completing the alternative assignment will have more cursory responses. (6) 
Discussion: The opportunity for students to learn directly from gender-diverse communities helps learners appreciate their lived experiences. This perspective is necessary to provide sufficient care across all patient populations. Early exposure to gender-diverse populations facilitates students’ self-directed life-long learning, as required for LCME accreditation. (7)

Premium content

Next from AMA Research Challenge 2025

A Deep-Learning Based Approach Uncovers Novel Mediators of Micro-RNA Restraint of Type-2 Immunity

Similar lecture

A Case of Excellent Response to FOLFIRINOX Therapy in a Stage IV Pancreatic Adenocarcinoma Patient