Background: Seborrheic keratoses (SKs) are common benign epidermal tumors that can cause significant cosmetic concerns or irritation. Although non-malignant, their appearance often leads patients to seek removal.

Purpose of Study: The purpose of this study is to provide an updated review of current and emerging treatments for seborrheic keratosis, evaluating their effectiveness, safety profiles, and impact on patient satisfaction to guide personalized, evidence-based management.

Methods: We performed a comprehensive literature review of SK treatments published from 2000 to 2025 using PubMed and major dermatology journals. Key outcomes assessed included treatment effectiveness, recurrence rates, adverse effects, and patient-reported satisfaction.

Results: Traditional treatments—such as cryotherapy, shave excision, and curettage—remain effective but are associated with risks of pigmentary changes or scarring. Recently, non-invasive therapies like topical hydrogen peroxide 40% solution have shown promise in randomized trials, offering comparable clearance rates with minimal downtime. Laser treatments, including Er:YAG and CO₂ lasers, are effective but cost-prohibitive for some patients. Patient satisfaction is highest with treatments that minimize pain, downtime, and post-treatment pigmentation changes.

Discussion: Choice of SK treatment should consider patient skin type, lesion location, cost, and cosmetic goals. Emerging therapies provide effective alternatives to traditional destructive methods, particularly for patients concerned about scarring or dyspigmentation.

Conclusion: Management of SKs is evolving beyond traditional modalities. Newer options, such as hydrogen peroxide 40%, provide effective, well-tolerated alternatives. A personalized approach based on patient preferences and lesion characteristics optimizes outcomes and satisfaction. Further studies comparing long-term efficacy and safety across treatment options are needed.