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Drug Target Interaction (DTI) prediction has witnessed promising performance boosts accompanied by advanced multimodal feature extraction. However, existing approaches suffer from two main difficulties. First, the complex protein structures cannot be well represented by current protein-sequence-based feature extractors. Second, the gap between protein and drug features increases the vulnerability of the obtained classifier thus degrading the prediction robustness. To address these issues, we propose a novel R-DTI method by exploring the second-order relevance in both protein structural feature extraction and DTI prediction phases. Specifically, we construct a pre-trained structural feature extractor that mines the atomic relevance of each amino acid. Then, an inter-feature structure-preserved Riemannian network is designed to expand the existing protein extraction patterns. To improve the prediction robustness, we also develop a Riemannian classifier that uses the second-order protein-drug relevance with a unified feature space. Extensive experimental results demonstrate the merits and superiority of our R-DTI against the state-of-the-art, achieving 1.4\% and 1.9\% higher AUC-ROC on the BindingDB and DrugBank datasets, respectively.

AAAI 2025

R-DTI: Drug Target Interaction Prediction Based on Second-Order Relevance Exploration

deep learning algorithms

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-26 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

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AAAI 2026

We are pleased to announce the Fortieth AAAI Conference on Artificial Intelligence (AAAI-26), which will be held in Singapore EXPO from January 20 to January 27, 2026.

poster

We are pleased to announce the Thirty-Ninth AAAI Conference on Artificial Intelligence (AAAI-25), which will be held in Philadelphia, Pennsylvania at the Pennsylvania Convention Center from February 25 to March 4, 2025.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-25 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

### [Invited Speakers](https://aaai.org/conference/aaai/aaai-25/aaai-25-invited-speakers/)

Register [here](https://aaai.org/conference/aaai/aaai-25/registration/)

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-25 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.



Fashion design is a challenging and complex process. Recent works on fashion generation and editing are all agnostic of the actual fashion design process, which limits their usage in practice. In this paper, we propose a novel hierarchical diffusion-based framework tailored for fashion design, coined as HieraFashDiff. Our model is designed to mimic the practical fashion design workflow, by unraveling the denosing process into two successive stages: 1) an ideation stage that generates design proposals given high-level concepts and 2) an iteration stage that continuously refines the proposals using low-level attributes. Our model supports fashion design generation and fine-grained local editing in a single framework. To train our model, we contribute a new dataset of full-body fashion images annotated with hierarchical text descriptions. Extensive evaluations show that, as compared to prior approaches, our method can generate fashion designs and edited results with higher fidelity and better prompt adherence, showing its promising potential to augment the practical fashion design workflow.

HieraFashDiff: Hierarchical Fashion Design with Multi-stage Diffusion Models

With the availability of egocentric 3D hand-object interaction datasets, there is increasing interest in developing unified models for hand-object pose estimation and action recognition. However, existing methods still struggle to recognise seen actions on unseen objects due to the limitations in representing object shape and movement using 3D bounding boxes. Additionally, the reliance on object templates at test time limits their generalisability to unseen objects. To address these challenges, we propose to leverage superquadrics as an alternative 3D object representation to bounding boxes and demonstrate their effectiveness on both template-free object reconstruction and action recognition tasks. Moreover, as we find that pure appearance-based methods can outperform the unified methods, the potential benefits from 3D geometric information remain unclear. Therefore, we study the compositionality of actions by considering a more challenging task where the training combinations of verbs and nouns do not overlap with the testing split. We extend H2O and FPHA datasets with compositional splits and design a novel collaborative learning framework that can explicitly reason about the geometric relations between hands and the manipulated object. Through extensive quantitative and qualitative evaluations, we demonstrate significant improvements over the state-of-the-arts in (compositional) action recognition.

Collaborative Learning for 3D Hand-Object Reconstruction and Compositional Action Recognition from Egocentric RGB Videos Using Superquadrics

Distributed machine learning (DML) is promising for training large models on  large datasets. In DML, multiple workers collaborate on the training of neural  networks, significantly reducing the time required for neural network training. The  efficiency of DML is heavily influenced by communication, making it crucial to balance the trade-off between communication cost and model performance in current  research. Local methods are excellent at reducing communication costs, yet face  degradation in accuracy and generalizability. Indeed, global knowledge is valuable  for improving performance in local methods. However, the theoretical analysis  of global knowledge validity is lacking, and global knowledge can currently only  be used in the global aggregation of local methods due to communication limitations and staleness. To this end, in this paper, we establish the mechanism  of global knowledge guidance and propose Adaptive Global Knowledge Guided  Distributed Stochastic Gradient Descent (AdaGK-SGD) to extend the guidance of  global knowledge to the whole distributed training process without any additional  communication. Specifically, we define the maximum lifetime of global knowledge based on the mechanism, and establish a correlation between the maximum  lifetime and the validity of global knowledge to circumvent the adverse effects  of global knowledge staleness. The Maximum Lifetime of Global Knowledge  module of our algorithm can be applied separately to other algorithms. In addition,  considering the application, we provide a straightforward and efficient strategy for  achieving the maximum lifetime adaptive setting. We establish the convergence  rate of AdaGK-SGD for convex and non-convex scenarios. Numerically, we find  that AdaGK-SGD can significantly improve the accuracy and generalizability of  distributed algorithms compared with existing methods.

AdaGK-SGD: Adaptive Global Knowledge Guided Distributed Stochastic Gradient Descent

With the continuous improvement of device imaging resolution, the popularity of Ultra-High-Definition (UHD) images is increasing. Unfortunately, existing methods for fusing multi-exposure images in dynamic scenes are designed for low-resolution images, which makes them inefficient for generating high-quality UHD images on a resource-constrained device. To alleviate the limitations of extremely long-sequence inputs, inspired by the Large Language Model (LLM) for processing infinitely long texts, we propose a novel learning paradigm to achieve UHD multi-exposure dynamic scene image fusion on a single consumer-grade GPU, named Infinite Pixel Learning (IPL). The design of our approach comes from three key components: The first step is to slice the input sequences to relieve the pressure generated by the model processing the data stream; Second, we develop an attention cache technique, which is similar to the KV cache for infinite data stream processing; Finally, we design a method for attention cache compression to alleviate the storage burden of the cache on the device. In addition, we provide a new UHD benchmark to evaluate the effectiveness of our method. Extensive experimental results show that our method maintains high-quality visual performance while fusing UHD dynamic multi-exposure images in real-time (>40fps) on a single consumer-grade GPU.

Ultra-High-Definition Dynamic Multi-Exposure Image Fusion via Infinite Pixel Learning

Adversarial examples’ (AE) transferability refers to the phenomenon that AEs crafted with one surrogate model can also fool other models. Notwithstanding remarkable progress in untargeted transferability, its targeted counterpart remains challenging. This paper proposes an $everywhere$ scheme to boost targeted transferability. Our idea is to attack a victim image both globally and locally. We aim to optimize ‘an army of targets’ in every local image region instead of previous works that optimize a high-confidence target in the image. Specifically, we split a victim image into non-overlap blocks and jointly mount a targeted attack on each block. Such a strategy mitigates transfer failures caused by attention inconsistency between surrogate and victim models and thus results in stronger transferability. Our approach is method-agnostic, which means it can be easily combined with existing transferable attacks for even higher transferability. Extensive experiments on ImageNet demonstrate that the proposed approach universally improves the state-of-the-art targeted attacks by a clear margin, e.g., the transferability of the widely adopted Logit attack can be improved by 28.8%~300%. We also evaluate the crafted AEs on a real-world platform: Google Cloud Vision. Results further support the superiority of the proposed method.

Everywhere Attack: Attacking Locally and Globally to Boost Targeted Transferability

Knowledge distillation (KD) is a model compression technique that transfers knowledge from a large teacher model to a smaller student model to enhance its performance. Existing methods often assume that the student model is inherently inferior to the teacher model. However, we identify that the fundamental issue affecting student performance is the bias transferred by the teacher. Current KD frameworks transmit both right and wrong knowledge, introducing bias that misleads the student model. To address this issue, we propose a novel strategy to rectify bias and greatly improve the student model's performance. Our strategy involves three steps: First, we differentiate knowledge and design a bias elimination method to filter out biases, retaining only the right knowledge for the student model to learn. Next, we propose a bias rectification method to rectify the teacher model's wrong predictions, fundamentally addressing bias interference. The student model learns from both the right knowledge and the rectified biases, greatly improving its prediction accuracy. Additionally, we introduce a dynamic learning approach with a loss function that updates weights dynamically, allowing the student model to quickly learn right knowledge-based easy tasks initially and tackle hard tasks corresponding to biases later, greatly enhancing the student model's learning efficiency. To the best of our knowledge, this is the first strategy enabling the student model to surpass the teacher model. Experiments demonstrate that our strategy, as a plug-and-play module, is versatile across various mainstream KD frameworks. We will release our code after the paper is accepted.

Can Students Beyond the Teacher? Distilling Knowledge from Teacher’s Bias

Few-Shot Video Object Segmentation (FSVOS) aims to achieve accurate segmentation of video sequences supported by limited annotated images. In this work, we analyze the deficiencies inherent in the use of object prototypes and pixel features as references in previous methods. Then we shed light on that part features, with the ability to adapt to appearance variations and resist noise, are advantageous as representative reference features for aligning support images and query videos. Therefore, we propose a Part Agent Learning Network (PALN) to leverage part features from two aspects. First, we elaborately employ Optimal Transport algorithm with equal partition constraint to make part agents capable of dividing support objects into diverse parts in an adaptive manner. Second, we design a dedicated cache mechanism to learn temporal part agents as lightweight historic target representation to exploit temporal consistency. With the aid of these learned part agents, our PALN can effectively achieve support-query alignment and temporal alignment for accurate segmentation of query videos. Extensive experimental results on two challenging benchmarks demonstrate that our method performs favorably against state-of-the-art FSVOS methods.

Beyond Pixel and Object: Part Feature as Reference for Few-Shot Video Object Segmentation

Federated learning is susceptible to model poisoning attacks, especially those meticulously crafted for servers. Traditional defense methods mainly focus on updating assessments or robust aggregation against manually crafted myopic attacks. When facing advanced attacks, their defense stability is notably insufficient. Therefore, it is imperative to develop adaptive defenses against such advanced poisoning attacks. We find that benign clients exhibit significantly higher data distribution stability than malicious clients in federated learning in both CV and NLP tasks. Therefore, the malicious clients can be recognized by observing the stability of their data distribution. In this paper, we propose AdaAggRL, an RL-based Adaptive Aggregation method, to defend against sophisticated poisoning attacks. Specifically, we first utilize distribution learning to simulate the clients' data distributions. Then, we use maximum mean discrepancy (MMD) to calculate the pairwise similarity of the current local model data distribution, its historical data distribution, and global model data distribution. Finally, we use policy learning to adaptively determine the aggregation weights based on the above similarities. Experiments on four real-world datasets demonstrate that the proposed defense model significantly outperforms widely adopted defense models for sophisticated attacks.

Defending Against Sophisticated Poisoning Attacks with RL-based Aggregation in Federated Learning

Graph unlearning technology has become increasingly important since the advent of the `right to be forgotten' and the growing concerns about the privacy and security of artificial intelligence. Graph unlearning aims to quickly eliminate the effects of specific data on graph neural networks (GNNs). However, most existing deterministic graph unlearning frameworks follow a balanced partition-submodel training-aggregation paradigm, resulting in a lack of structural information between subgraph neighborhoods and redundant unlearning parameter calculations. To address this issue, we propose a novel $\underline{G}$raph $\underline{S}$tructure $\underline{M}$apping $\underline{U}$nlearning paradigm ($\textbf{GSMU}$) and a novel method based on it named $\underline{\textbf{C}}$ommunity-centric $\underline{\textbf{G}}$raph $\underline{\textbf{E}}$raser ($\textbf{CGE}$). CGE maps community subgraphs to nodes, thereby enabling the reconstruction of a node-level unlearning operation within a reduced mapped graph. CGE makes the exponential reduction of both the amount of training data and the number of unlearning parameters. Extensive experiments conducted on five real-world datasets and three widely used GNN backbones have verified the high performance and efficiency of our CGE method, highlighting its potential in the field of graph unlearning. The main source code of CGE can be found in the Supplementary Material.

Community-Centric Graph Unlearning

Recent years have witnessed remarkable progress in 3D content generation. However, corresponding evaluation methods struggle to keep pace. Automatic approaches have proven challenging to align with human preferences, and the mixed comparison of text- and image-driven methods often leads to unfair evaluations. In this paper, we present a comprehensive framework to better align and evaluate multi-view diffusion models with human preferences. To begin with, we first collect and filter a standardized image prompt set from DALL·E and Objaverse, which we then use to generate multi-view assets with several multi-view diffusion models. Through a systematic ranking pipeline on these assets, we obtain a human annotation dataset with 16k expert pairwise comparisons and train a reward model, coined MVReward, to effectively encode human preferences. With MVReward, image-driven 3D methods can be evaluated against each other in a more fair and transparent manner. Building on this, we further propose Multi-View Preference Learning (MVP), a plug-and-play multi-view diffusion tuning strategy. Extensive experiments demonstrate that MVReward can serve as a reliable metric and MVP consistently enhances the alignment of multi-view diffusion models with human preferences.

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