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Medical benchmark datasets significantly contribute to developing Large Language Models (LLMs) for medical knowledge extraction, diagnosis, summarization, and other uses.
Yet, current benchmarks are mainly derived from exam questions given to medical students or cases described in the medical literature, lacking the complexity of real-world patient cases that deviate from classic textbook abstractions. These include rare diseases, uncommon presentations of common diseases, and unexpected treatment responses. 
Here, we construct Clinically Uncommon Patient Cases and Diagnosis Dataset (CUPCase) based on 3,563 real-world case reports from BMC, which we formulate into diagnoses in open-ended textual format and as multiple-choice options with distractors.
Using this dataset, we evaluate the ability of state-of-the-art LLMs, including both general-purpose and Clinical LLMs, to identify and correctly diagnose a patient case, and test models&#39; performance when only partial information about cases is available.
Our findings show that general-purpose GPT-4o attains the best performance in both the multiple-choice task (average accuracy of 87.9%) and the open-ended task (BERTScore F1 of 0.764), outperforming several LLMs with a focus on the medical domain such as Meditron-70B and MedLM-Large. 
Moreover, GPT-4o was able to maintain 87% and 88% of its performance with only the first 20% of tokens of the case presentation in multiple-choice and free text, respectively,  highlighting the potential of LLMs to aid in early diagnosis in real-world cases. An error analysis demonstrates the complexity of the task, and attempts to hypothesise about the models&#39; reasoning.
CUPCase expands our ability to evaluate LLMs for clinical decision support in an open and reproducible manner.

AAAI 2025

CUPCase: Clinically Uncommon Patient Cases and Diagnoses Dataset

## Welcome to EMNLP 2024! 
We are excited to welcome you to one of the most prominent conferences in the field of Natural Language Processing. This year, EMNLP 2024 is being held in a hybrid format,
offering both virtual and in-person participation in beautiful Miami. Due to a record-breaking number of submissions, we've expanded the total number of accepted papers to accommodate more cutting-edge research from around the globe.
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EMNLP 2024

EMNLP 2024 will take place in Miami, Florida from Nov 12th to Nov 16th, 2024, at the Hyatt Regency Miami Hote and on Underline for remote participants.

Medical benchmark datasets significantly contribute to developing Large Language Models (LLMs) for medical knowledge extraction, diagnosis, summarization, and other uses.
Yet, current benchmarks are mainly derived from exam questions given to medical students or cases described in the medical literature, lacking the complexity of real-world patient cases that deviate from classic textbook abstractions. These include rare diseases, uncommon presentations of common diseases, and unexpected treatment responses. 
Here, we construct Clinically Uncommon Patient Cases and Diagnosis Dataset (CUPCase) based on 3,563 real-world case reports from BMC, which we formulate into diagnoses in open-ended textual format and as multiple-choice options with distractors.
Using this dataset, we evaluate the ability of state-of-the-art LLMs, including both general-purpose and Clinical LLMs, to identify and correctly diagnose a patient case, and test models' performance when only partial information about cases is available.
Our findings show that general-purpose GPT-4o attains the best performance in both the multiple-choice task (average accuracy of 87.9%) and the open-ended task (BERTScore F1 of 0.764), outperforming several LLMs with a focus on the medical domain such as Meditron-70B and MedLM-Large. 
Moreover, GPT-4o was able to maintain 87% and 88% of its performance with only the first 20% of tokens of the case presentation in multiple-choice and free text, respectively,  highlighting the potential of LLMs to aid in early diagnosis in real-world cases. An error analysis demonstrates the complexity of the task, and attempts to hypothesise about the models' reasoning.
CUPCase expands our ability to evaluate LLMs for clinical decision support in an open and reproducible manner.

poster

We are pleased to announce the Thirty-Ninth AAAI Conference on Artificial Intelligence (AAAI-25), which will be held in Philadelphia, Pennsylvania at the Pennsylvania Convention Center from February 25 to March 4, 2025.

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-25 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.

### [Invited Speakers](https://aaai.org/conference/aaai/aaai-25/aaai-25-invited-speakers/)

Register [here](https://aaai.org/conference/aaai/aaai-25/registration/)

The purpose of the AAAI conference series is to promote research in Artificial Intelligence (AI) and foster scientific exchange between researchers, practitioners, scientists, students, and engineers across the entirety of AI and its affiliated disciplines. AAAI-25 will feature technical paper presentations, special tracks, invited speakers, workshops, tutorials, poster sessions, senior member presentations, competitions, and exhibit programs, and a range of other activities to be announced.



Federated Learning in healthcare ensures patient privacy by allowing hospitals to collaboratively train machine learning models while keeping sensitive medical data secure and localized. Most existing research in Federated Learning (FL) has concentrated on unimodal scenarios, where all healthcare institutes share the same type of data. However, in real-world healthcare situations, some clients may have access to multiple types of data pertaining to the same disease. Multimodal Federated Learning (MMFL) utilizes multiple modalities in each client to build a more powerful Federated Learning (FL) model than its unimodal counterpart. However, the impact of missing modality in different clients, called modality incongruity, has been greatly overlooked. This paper, for the first time, analyses the impact of modality incongruity and reveals its connection with data heterogeneity across participating clients. We particularly inspect whether incongruent MMFL with unimodal and multimodal clients is more beneficial than unimodal FL. Furthermore, we examine three potential routes of addressing this issue. Firstly, we study the effectiveness of various self-attention mechanisms towards incongruity-agnostic information fusion in MMFL. Secondly, we introduce a modality imputation network (MIN) pre-trained in a multimodal client for modality translation in unimodal clients and investigate its potential towards mitigating the missing modality problem. Thirdly, we assess the capability of client-level and server-level regularization techniques towards mitigating modality incongruity effects. Experiments are conducted with Chest X-Ray and radiology reports under several MMFL settings on two publicly available real-world datasets, MIMIC-CXR and Open-I.

Incongruent Multimodal Federated Learning for Medical Vision and Language-based Multi-label Disease Detection

As global populations age rapidly, incorporating age-specific considerations into urban planning is crucial for transforming cities into supportive environments for both aging populations and sustainable development. However, current urban development practices fall significantly short in implementing age-friendly planning, leading to elderly services that are insufficient and unevenly distributed across regions. This underscores the urgent need for age-friendly urban renewal strategies. To tackle this challenge, our work focuses on generating optimized planning schemes for urban aging facilities, tailored to the unique demands of age-friendly community planning. We introduce a novel framework called **F**airness-driven **A**ge-friendly community **P**lanning via **C**onditional **D**iffusion generation (FAP-CD) that utilizes a conditioned graph denoising diffusion probabilistic model to learn the conditional joint probability distribution of aging facilities and their spatial relationships at a fine-grained regional level. Specifically, this approach generates optimized spatial distributions of facilities from noisy graphs, conditioned on the needs of the elderly during the denoising diffusion process. In the training phase, we incorporate a demand-fairness pre-training module that leverages an attention mechanism and min-max optimization to integrate community demand features with facility characteristics, ensuring a balanced distribution of services across different regions. Additionally, we use a discrete graph structure to represent potential walkable accessibility within regional road networks, serving as a guiding condition to accelerate model sampling. We also design a graph denoising network with an attribute augmentation module and a hybrid graph message aggregation module to enhance the integration of neighbor and global node and edge information. Empirical results across multiple metrics highlight our method's superior ability to balance age-friendly needs with regional equity, achieving an average improvement of 41\% over various competitive baseline models.

FAP-CD: Fairness-Driven Age-Friendly Community Planning via Conditional Diffusion Generation

Rendering photorealistic head avatars from arbitrary viewpoints is crucial for various applications like virtual reality. Although previous methods based on Neural Radiance Fields (NeRF) can achieve impressive results, they lack fidelity and efficiency. Recent methods using 3D Gaussian Splatting (3DGS) have improved rendering quality and real-time performance but still require significant storage overhead. In this paper, we introduce a method called GraphAvatar that utilizes Graph Neural Networks (GNN) to generate 3D Gaussians for the head avatar. Specifically, GraphAvatar trains a geometric GNN and an appearance GNN to generate the attributes of the 3D Gaussians from the tracked mesh. Therefore, our method can store the GNN models instead of the 3D Gaussians, significantly reducing the storage overhead to just 10MB. To reduce the impact of face-tracking errors, we also present a novel graph-guided optimization module to refine face-tracking parameters during training. Finally, we introduce a 3D-aware enhancer for post-processing to enhance the rendering quality. We conduct comprehensive experiments to demonstrate the advantages of GraphAvatar, surpassing existing methods in visual fidelity and storage consumption. The ablation study sheds light on the trade-offs between rendering quality and model size. The code will be released.

GraphAvatar: Compact Head Avatars with GNN-Generated 3D Gaussians

Incomplete multi-view clustering (IMVC) has garnered increasing attention in recent years due to the common issue of missing data in multi-view datasets. The primary approach to address this challenge involves recovering the missing views before applying conventional multi-view clustering methods. Although imputation-based IMVC methods have achieved significant improvements, they still encounter notable limitations: 1) heavy reliance  on paired data for training the data recovery module, which is impractical in real scenarios with high missing data rates; 2) the generated data often lacks diversity and discriminability, resulting in suboptimal clustering results. 
To address these shortcomings, we propose a novel IMVC method called Diffusion Contrastive Generation (DCG). Motivated by the consistency between the diffusion and clustering processes, DCG learns the distribution characteristics to enhance clustering by applying forward diffusion and reverse denoising processes to intra-view data.
By performing contrastive learning on a limited  set of paired multi-view samples, DCG can align the generated views with the real views, facilitating accurate recovery of views across arbitrary missing view scenarios. Additionally, DCG integrates instance-level and category-level interactive learning to exploit the consistent and complementary information available in multi-view data, achieving robust and end-to-end clustering. 
Extensive experiments demonstrate that our method outperforms state-of-the-art approaches.

Incomplete Multi-view Clustering via Diffusion Contrastive Generation

We address the challenging task of neural machine translation (NMT) in the entertainment domain, where the objective is to automatically translate a given dialogue from a source language content to a target language. This task has various applications, particularly in automatic dubbing, subtitling, and other content localization tasks, enabling source content to reach a wider audience. Traditional NMT systems typically translate individual sentences in isolation, without facilitating knowledge transfer of crucial elements such as the \textit{context} and \textit{style} from previously encountered sentences. In this work, we emphasize the significance of these fundamental aspects in producing pertinent and captivating translations. We demonstrate their significance through several examples and propose a novel framework for entertainment translation, which, to our knowledge, is the first of its kind. Furthermore, we introduce an algorithm to estimate the context and style of the current \textit{session} and use these estimations to generate a \textit{prompt} that guides a Large Language Model (LLM) to generate high-quality translations. Our method is both language and LLM-agnostic, making it a general-purpose tool. We demonstrate the effectiveness of our algorithm through various numerical studies and observe significant improvement in the COMET scores over various state-of-the-art LLMs. Moreover, our proposed method consistently outperforms baseline LLMs in terms of win-ratio.

Enhancing Entertainment Translation for Indian Languages Using Adaptive Context, Style and LLMs

We analyze a distributed algorithm to compute a low-rank matrix factorization on $N$ clients, each holding a local dataset $\mathbf{S}^i \in \mathbb{R}^{n_i \times d}$, mathematically, we seek to solve $min_{\mathbf{U}^i \in \mathbb{R}^{n_i\times r}, \mathbf{V}\in \mathbb{R}^{d \times r} } \frac{1}{2} \sum_{i=1}^N \|\mathbf{S}^i - \mathbf{U}^i \mathbf{V}^\top\|^2_{\text{F}}$. Considering a power initialization of $\mathbf{V}$, we rewrite the previous smooth non-convex problem into a smooth strongly-convex problem that we solve using a parallel Nesterov gradient descent potentially requiring a single step of communication at the initialization step. For any client $i$ in $\{1, \dots, N\}$, we obtain a global $\mathbf{V}$ in $\mathbb{R}^{d \times r}$ common to all clients and a local variable $\mathbf{U}^i$ in $\mathbb{R}^{n_i \times r}$. We provide a linear rate of convergence of the excess loss which depends on $\sigma_{\max} / \sigma_{r}$, where $\sigma_{r}$ is the $r^{\mathrm{th}}$ singular value of the concatenation $\mathbf{S}$ of the matrices $(\mathbf{S}^i)^N_{i=1}$. This result improves the rates of convergence given in the literature, which depend on $\sigma_{\max}^2 / \sigma_{\min}^2$. We provide an upper bound on the Frobenius-norm error of reconstruction under the power initialization strategy. We complete our analysis with experiments on both synthetic and real data.

In-depth Analysis of Low-rank Matrix Factorisation in a Federated Setting

Transformer-based models have recently achieved outstanding performance in image matting. However, their application to high-resolution images remains challenging due to the quadratic complexity of global self-attention. To address this issue, we propose MEMatte, a memory-efficient matting framework for processing high-resolution images. MEMatte incorporates a router before each global attention block, directing informative tokens to the global attention while routing other tokens to a Lightweight Token Refinement Module (LTRM). Specifically, the router employs a local-global strategy to predict the routing probability of each token, and the LTRM utilizes efficient modules to simulate global attention. Additionally, we introduce a Batch-constrained Adaptive Token Routing (BATR) mechanism, which allows each router to dynamically route tokens based on image content and the stages of attention block in the network. Furthermore, we construct an ultra high-resolution image matting dataset, UHR-395, comprising 35,500 training images and 1,000 test images, with an average resolution of $4872\times6017$. This dataset is created by compositing 395 different alpha mattes across 11 categories onto various backgrounds, all with high-quality manual annotation. Extensive experiments demonstrate that MEMatte outperforms existing methods on both high-resolution and real-world datasets, significantly reducing memory usage by approximately 88\% and latency by 50\% on the Composition-1K benchmark.

Memory Efficient Matting with Adaptive Token Routing

In the era of big data, cross-modal retrieval is increasingly important in research and application. Given the latent complexity and non-intuitive nature of cross-modal relationships, leveraging external knowledge such as large models has become a popular approach to facilitate modality alignment. Existing methods typically address these challenges by fine-tuning model encoders or using a fixed number of prompts. However, these approaches struggle with the significant information asymmetry between image-text pairs and the high distribution diversity of image data. These limitations not only introduce noise during training but also constrain the accuracy and generalization capabilities of these methods in cross-modal retrieval tasks. To address the above issues, this paper proposes Adaptive Prompt-Based Semantic Embedding with Inspired Potential of Implicit Knowledge (APSE-IPIK). On one hand, we propose an inspiring potential strategy to extract fine-grained and multi-perspective text descriptions from large-scale pre-trained multimodal models, which can be seen as implicit knowledge injection. These descriptions, once refined and optimized, are integrated into the visual semantic embedding to balance the information asymmetry between different modalities, thereby reducing the embedding of inaccurate mapping relationships. On the other hand, we construct an instance-level query-based prompt pool to adaptively extract the most relevant prompts, addressing alignment biases caused by intra-modal (especially image) data diversity and improving alignment accuracy. Extensive experiments are conducted on two widely used datasets, Flickr30k and MSCOCO, which show the effectiveness of the proposed method.

Adaptive Prompt-Based Semantic Embedding with Inspire Potential of Implicit Knowledge for Cross-Modal Retrieval

Learning graph generative models over latent spaces has received  less attention compared to models that operate on the original data space and has so far demonstrated lacklustre performance. We present GLAD a latent space graph generative model. Unlike most previous latent space graph generative models, GLAD operates on a discrete latent space that preserves to a significant extent the discrete nature of the graph structures making no unnatural assumptions such as latent space continuity. We learn the prior of our discrete latent space by adapting diffusion bridges to its structure. By operating over an appropriately constructed latent space we avoid relying on decompositions that are often used in models that operate in the original data space. We present experiments on a series of graph benchmark datasets that demonstrates GLAD as the first equivariant latent graph generative method achieves competitive performance with the state of the art baselines.

GLAD: Improving Latent Graph Generative Modeling with Simple Quantization

ControlNet has significantly advanced controllable image generation by integrating dense conditions (such as depth and canny edges) with text-to-image diffusion models. However, ControlNet's integration requires an additional amount nearly equal to half of the base diffusion model's parameters, making it inefficient. To address this, we introduce Simple-ControlNet, an efficient and streamlined network for controllable text-to-image generation. It employs a single-scale projection layer to incorporate condition information into the denoising U-Net. It is supplemented by Low-Rank Adapter (LoRA) parameters to facilitate condition learning. Impressively, Simple-ControlNet requires fewer than 3 million parameters for the control mechanism—substantially less than the 300 million needed by ControlNet. Our extensive experiments confirm that Simple-ControlNet matches and surpasses ControlNet's performance across a broad range of tasks and base diffusion models, showcasing its utility and efficiency. All pre-trained models will be made available to the open-source community.

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Incongruent Multimodal Federated Learning for Medical Vision and Language-based Multi-label Disease Detection

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